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Published in: European Archives of Oto-Rhino-Laryngology 1/2017

01-01-2017 | Head and Neck

Management of locoregional recurrence in cutaneous squamous cell carcinoma of the head and neck

Authors: Ulrich Strassen, Benedikt Hofauer, Christian Jacobi, Andreas Knopf

Published in: European Archives of Oto-Rhino-Laryngology | Issue 1/2017

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Abstract

Cutaneous squamous cell carcinomas often affect elderly patients. Follow-up monitoring is difficult in these patients due to their multi-morbidity and reduced compliance. Tumour recurrence is consequently diagnosed in advanced tumour stages. Surgical therapy with curative intention often requires extended resections. The study at hand should determine whether surgical concepts are warranted in this collective. Sixty-seven patients who underwent surgical procedure due to recurrent disease of cutaneous head and neck squamous cell carcinoma were included. The cohort was divided in patients with/without adjuvant therapeutic regimens. Data were assessed retrospectively. Complete tumour resection was achieved in 85 % of our patients. Patients with adjuvant treatment demonstrated a favorable 5-year-recurrence-free interval (78 vs 30 %) and overall survival (79 vs 46 %). Complete surgical resection of advanced recurrent head and neck cutaneous squamous cell carcinomas is possible and yields favorable results in terms of survival, especially if combined with adjuvant treatment.
Literature
1.
go back to reference Katalinic A, Kunze U, Schafer T (2003) Epidemiology of cutaneous melanoma and non-melanoma skin cancer in Schleswig-Holstein, Germany: incidence, clinical subtypes, tumour stages and localization (epidemiology of skin cancer). Br J Dermatol 149(6):1200–1206CrossRefPubMed Katalinic A, Kunze U, Schafer T (2003) Epidemiology of cutaneous melanoma and non-melanoma skin cancer in Schleswig-Holstein, Germany: incidence, clinical subtypes, tumour stages and localization (epidemiology of skin cancer). Br J Dermatol 149(6):1200–1206CrossRefPubMed
3.
go back to reference Goon PK, Greenberg DC, Igali L, Levell NJ (2015) Squamous cell carcinoma of the skin has more than doubled over the last decade in the UK. Acta Dermato-Venereol. doi:10.2340/00015555-2310 Goon PK, Greenberg DC, Igali L, Levell NJ (2015) Squamous cell carcinoma of the skin has more than doubled over the last decade in the UK. Acta Dermato-Venereol. doi:10.​2340/​00015555-2310
4.
5.
go back to reference Brantsch KD, Meisner C, Schonfisch B, Trilling B, Wehner-Caroli J, Rocken M, Breuninger H (2008) Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study. Lancet Oncol 9(8):713–720. doi:10.1016/S1470-2045(08)70178-5 CrossRefPubMed Brantsch KD, Meisner C, Schonfisch B, Trilling B, Wehner-Caroli J, Rocken M, Breuninger H (2008) Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study. Lancet Oncol 9(8):713–720. doi:10.​1016/​S1470-2045(08)70178-5 CrossRefPubMed
6.
go back to reference Stratigos A, Garbe C, Lebbe C, Malvehy J, del Marmol V, Pehamberger H, Peris K, Becker JC, Zalaudek I, Saiag P, Middleton MR, Bastholt L, Testori A, Grob JJ (2015) Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline. Eur J Cancer 51(14):1989–2007. doi:10.1016/j.ejca.2015.06.110 CrossRefPubMed Stratigos A, Garbe C, Lebbe C, Malvehy J, del Marmol V, Pehamberger H, Peris K, Becker JC, Zalaudek I, Saiag P, Middleton MR, Bastholt L, Testori A, Grob JJ (2015) Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline. Eur J Cancer 51(14):1989–2007. doi:10.​1016/​j.​ejca.​2015.​06.​110 CrossRefPubMed
7.
go back to reference Chu MB, Slutsky JB, Dhandha MM, Beal BT, Armbrecht ES, Walker RJ, Varvares MA, Fosko SW (2014) Evaluation of the definitions of “high-risk” cutaneous squamous cell carcinoma using the american joint committee on cancer staging criteria and national comprehensive cancer network guidelines. J Skin Cancer 2014:154340. doi:10.1155/2014/154340 CrossRefPubMedPubMedCentral Chu MB, Slutsky JB, Dhandha MM, Beal BT, Armbrecht ES, Walker RJ, Varvares MA, Fosko SW (2014) Evaluation of the definitions of “high-risk” cutaneous squamous cell carcinoma using the american joint committee on cancer staging criteria and national comprehensive cancer network guidelines. J Skin Cancer 2014:154340. doi:10.​1155/​2014/​154340 CrossRefPubMedPubMedCentral
8.
go back to reference Silberstein E, Sofrin E, Bogdanov-Berezovsky A, Nash M, Segal N (2015) Lymph node metastasis in cutaneous head and neck squamous cell carcinoma. Dermatol Surg Off Publ Am Soc Dermatol Surg [et al] 41(10):1126–1129. doi:10.1097/DSS.0000000000000488 Silberstein E, Sofrin E, Bogdanov-Berezovsky A, Nash M, Segal N (2015) Lymph node metastasis in cutaneous head and neck squamous cell carcinoma. Dermatol Surg Off Publ Am Soc Dermatol Surg [et al] 41(10):1126–1129. doi:10.​1097/​DSS.​0000000000000488​
9.
go back to reference Givi B, Andersen PE, Diggs BS, Wax MK, Gross ND (2011) Outcome of patients treated surgically for lymph node metastases from cutaneous squamous cell carcinoma of the head and neck. Head Neck 33(7):999–1004. doi:10.1002/hed.21574 CrossRefPubMed Givi B, Andersen PE, Diggs BS, Wax MK, Gross ND (2011) Outcome of patients treated surgically for lymph node metastases from cutaneous squamous cell carcinoma of the head and neck. Head Neck 33(7):999–1004. doi:10.​1002/​hed.​21574 CrossRefPubMed
10.
go back to reference Porceddu SV, Veness MJ, Guminski A (2015) Nonmelanoma cutaneous head and neck cancer and Merkel cell carcinoma: current concepts, advances, and controversies. J Clin Oncol Off J Am Soc Clin Oncol 33(29):3338–3345. doi:10.1200/JCO.2014.60.7333 CrossRef Porceddu SV, Veness MJ, Guminski A (2015) Nonmelanoma cutaneous head and neck cancer and Merkel cell carcinoma: current concepts, advances, and controversies. J Clin Oncol Off J Am Soc Clin Oncol 33(29):3338–3345. doi:10.​1200/​JCO.​2014.​60.​7333 CrossRef
12.
go back to reference O’Hara J, Ferlito A, Takes RP, Rinaldo A, Strojan P, Shaha AR, Rodrigo JP, Paleri V (2011) Cutaneous squamous cell carcinoma of the head and neck metastasizing to the parotid gland—a review of current recommendations. Head Neck 33(12):1789–1795. doi:10.1002/hed.21583 CrossRefPubMed O’Hara J, Ferlito A, Takes RP, Rinaldo A, Strojan P, Shaha AR, Rodrigo JP, Paleri V (2011) Cutaneous squamous cell carcinoma of the head and neck metastasizing to the parotid gland—a review of current recommendations. Head Neck 33(12):1789–1795. doi:10.​1002/​hed.​21583 CrossRefPubMed
13.
go back to reference Warren TA, Panizza B, Porceddu SV, Gandhi M, Patel P, Wood M, Nagle CM, Redmond M (2014) Outcomes after surgery and postoperative radiotherapy for perineural spread of head and neck cutaneous squamous cell carcinoma. Head Neck. doi:10.1002/hed.23982 Warren TA, Panizza B, Porceddu SV, Gandhi M, Patel P, Wood M, Nagle CM, Redmond M (2014) Outcomes after surgery and postoperative radiotherapy for perineural spread of head and neck cutaneous squamous cell carcinoma. Head Neck. doi:10.​1002/​hed.​23982
15.
go back to reference Szewczyk M, Pazdrowski J, Golusinski P, Danczak-Pazdrowska A, Marszalek S, Golusinski W (2015) Analysis of selected risk factors for nodal metastases in head and neck cutaneous squamous cell carcinoma. Eur Arch Oto-Rhino-Laryngol Off J Eur Fed Oto-Rhino-Laryngol Soc 272(10):3007–3012. doi:10.1007/s00405-014-3261-6 CrossRef Szewczyk M, Pazdrowski J, Golusinski P, Danczak-Pazdrowska A, Marszalek S, Golusinski W (2015) Analysis of selected risk factors for nodal metastases in head and neck cutaneous squamous cell carcinoma. Eur Arch Oto-Rhino-Laryngol Off J Eur Fed Oto-Rhino-Laryngol Soc 272(10):3007–3012. doi:10.​1007/​s00405-014-3261-6 CrossRef
16.
go back to reference Wermker K, Belok F, Schipmann S, Klein M, Schulze HJ, Hallermann C (2015) Prediction model for lymph node metastasis and recommendations for elective neck dissection in lip cancer. J Cranio-Maxillo-Fac Surg Off Publ Eur Assoc Cranio-Maxillo-Facial Surg 43(4):545–552. doi:10.1016/j.jcms.2015.02.002 CrossRef Wermker K, Belok F, Schipmann S, Klein M, Schulze HJ, Hallermann C (2015) Prediction model for lymph node metastasis and recommendations for elective neck dissection in lip cancer. J Cranio-Maxillo-Fac Surg Off Publ Eur Assoc Cranio-Maxillo-Facial Surg 43(4):545–552. doi:10.​1016/​j.​jcms.​2015.​02.​002 CrossRef
17.
go back to reference Wermker K, Kluwig J, Schipmann S, Klein M, Schulze HJ, Hallermann C (2015) Prediction score for lymph node metastasis from cutaneous squamous cell carcinoma of the external ear. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol 41(1):128–135. doi:10.1016/j.ejso.2014.07.039 Wermker K, Kluwig J, Schipmann S, Klein M, Schulze HJ, Hallermann C (2015) Prediction score for lymph node metastasis from cutaneous squamous cell carcinoma of the external ear. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol 41(1):128–135. doi:10.​1016/​j.​ejso.​2014.​07.​039
Metadata
Title
Management of locoregional recurrence in cutaneous squamous cell carcinoma of the head and neck
Authors
Ulrich Strassen
Benedikt Hofauer
Christian Jacobi
Andreas Knopf
Publication date
01-01-2017
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 1/2017
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-016-4243-7

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