Skip to main content
Top
Published in: Journal of Gastrointestinal Surgery 11/2011

01-11-2011 | Original Article

Management of Gastrointestinal Leaks After Minimally Invasive Esophagectomy: Conventional Treatments vs. Endoscopic Stenting

Authors: Ninh T. Nguyen, Patrick Donohue Rudersdorf, Brian R. Smith, Kevin Reavis, Xuan-Mai T. Nguyen, Michael J. Stamos

Published in: Journal of Gastrointestinal Surgery | Issue 11/2011

Login to get access

Abstract

Introduction

Gastrointestinal leak is a dreaded complication after esophagectomy. Conventional treatments for leak include conservative therapy, surgical reoperation, and even complete gastrointestinal (GI) diversion. The aim of this study was to evaluate the impact of endoluminal stenting in the management of esophagogastric leak after esophagectomy.

Methods

Data on 18 (11.3%) of 160 patients who developed postoperative leaks after minimally invasive esophagectomy were reviewed. Indications for esophagectomy included carcinoma (n = 14), Barrett’s with high-grade dysplasia (n = 3), and benign stricture (n = 1). Neoadjuvant therapy was used in 57.1% of patients with carcinoma. The first nine patients underwent conventional treatments for leak whereas the latter nine patients underwent endoscopic esophageal covered stenting as primary therapy. There were 5 cervical and 13 intrathoracic anastomotic leaks. Main outcome measures included patient characteristics, types of treatment, length of hospital stay, morbidity, and mortality.

Results

Subjects were 16 males and 2 females with a mean age of 66 years. In the conventional treatment group, leaks were treated with neck drainage (n = 4), GI diversion (n = 2), and thoracoscopic drainage with or without repair or T-tube placement (n = 3). In the endoscopy group, all leaks were treated with endoscopic covered stenting with or without percutaneous drainage (n = 9). Control of leaks occurred in 89% of patients in the conventional treatment group vs. 100% of patients in the endoscopic stenting group. Three patients in the conventional treatment group (33%) required esophageal diversion compared to none of the patients in the endoscopy group. The 60-day or in-hospital mortality was 0% for both groups.

Conclusion

In our clinical practice, there has been a shift in the management of esophagogastric anastomotic leaks to nonsurgical therapy using endoscopic esophageal covered stenting. Endoluminal stenting is a safe and effective alternative in the management of GI leaks.
Literature
1.
go back to reference Iannettoni MD, Whyte RI, Orringer MB. Catastrophic complications of the cervical esophagogastric anastomosis. J Thorac Cardiovasc Surg 1995;110:1493–1500.PubMedCrossRef Iannettoni MD, Whyte RI, Orringer MB. Catastrophic complications of the cervical esophagogastric anastomosis. J Thorac Cardiovasc Surg 1995;110:1493–1500.PubMedCrossRef
2.
go back to reference Korst RJ, Port JL, Lee PC, Altorki NK. Intrathoracic manifestations of cervical anastomotic leaks after transthoracic esophagectomy for carcinoma. Ann Thorac Surg 2005;80:1185–1190.PubMedCrossRef Korst RJ, Port JL, Lee PC, Altorki NK. Intrathoracic manifestations of cervical anastomotic leaks after transthoracic esophagectomy for carcinoma. Ann Thorac Surg 2005;80:1185–1190.PubMedCrossRef
3.
go back to reference Nguyen NT, Follette DM, Roberts PF, et al. Thoracoscopic management of postoperative esophageal leak. J Thorac Cardiovasc Surg 2001;121:391–392.PubMedCrossRef Nguyen NT, Follette DM, Roberts PF, et al. Thoracoscopic management of postoperative esophageal leak. J Thorac Cardiovasc Surg 2001;121:391–392.PubMedCrossRef
4.
go back to reference Peters JH, Craanen ME, van der Peet DL, et al. Self-expanding metal stents for the treatment of intrathoracic esophageal anastomotic leaks following esophagectomy. Am J Gastroenterol 2006;101:1393−1395.PubMedCrossRef Peters JH, Craanen ME, van der Peet DL, et al. Self-expanding metal stents for the treatment of intrathoracic esophageal anastomotic leaks following esophagectomy. Am J Gastroenterol 2006;101:1393−1395.PubMedCrossRef
5.
go back to reference Hunerbein M, Stroszczynski C et al. Treatment of thoracic anastomotic leaks after esophagectomy with self-expanding plastic stents. Ann Surg. 2004 Nov:240(5):801–7.PubMedCrossRef Hunerbein M, Stroszczynski C et al. Treatment of thoracic anastomotic leaks after esophagectomy with self-expanding plastic stents. Ann Surg. 2004 Nov:240(5):801–7.PubMedCrossRef
6.
go back to reference Alanezi K, Urschel JD. Mortality secondary to esophageal anastomotic leak. Ann Thorac Cardiovasc Surg 2004;10:71–75.PubMed Alanezi K, Urschel JD. Mortality secondary to esophageal anastomotic leak. Ann Thorac Cardiovasc Surg 2004;10:71–75.PubMed
7.
go back to reference Martin LW, Swisher SG, Hofstetter W, et al. Intrathoracic leaks following esophagectomy are no longer associated with increased mortality. Ann Surg 2005;242:392−399.PubMed Martin LW, Swisher SG, Hofstetter W, et al. Intrathoracic leaks following esophagectomy are no longer associated with increased mortality. Ann Surg 2005;242:392−399.PubMed
8.
go back to reference Junemann-Ramirez M, Awan MY, Khan ZM, Rahamim JS. Anastomotic leakage post-esophagogastrectomy for esophageal carcinoma: retrospective analysis of predictive factors, management and influence on longterm survival in a high volume centre. Eur J Cardiothorac Surg 2005;27:3–7.PubMedCrossRef Junemann-Ramirez M, Awan MY, Khan ZM, Rahamim JS. Anastomotic leakage post-esophagogastrectomy for esophageal carcinoma: retrospective analysis of predictive factors, management and influence on longterm survival in a high volume centre. Eur J Cardiothorac Surg 2005;27:3–7.PubMedCrossRef
9.
go back to reference Crestanello JA, Deschamps C, Cassivi SD, et al. Selective management of intrathoracic anastomotic leak after esophagectomy. J Thorac Cardiovasc Surg 2005;129:254–260.PubMedCrossRef Crestanello JA, Deschamps C, Cassivi SD, et al. Selective management of intrathoracic anastomotic leak after esophagectomy. J Thorac Cardiovasc Surg 2005;129:254–260.PubMedCrossRef
10.
go back to reference Page RD, Schackcloth MJ, Russell GN, Pennefather SH. Surgical treatment of anastomotic leaks after oesophagectomy. Eur J Cardiothorac Surg 2005;27:337–343.PubMedCrossRef Page RD, Schackcloth MJ, Russell GN, Pennefather SH. Surgical treatment of anastomotic leaks after oesophagectomy. Eur J Cardiothorac Surg 2005;27:337–343.PubMedCrossRef
11.
go back to reference Turkyilmaz A, Eroglu A, Aydin Y, et al. The management of esophagogastric anastomotic leak after esophagectomy for esophageal carcinoma. Dis Esophagus 2009;22:119–126.PubMedCrossRef Turkyilmaz A, Eroglu A, Aydin Y, et al. The management of esophagogastric anastomotic leak after esophagectomy for esophageal carcinoma. Dis Esophagus 2009;22:119–126.PubMedCrossRef
12.
go back to reference Schubert D, Scheidbach H, Kuhn R et al. Endoscopic treatment of thoracic esophageal anastomotic leaks by using silicone-covered, self-expanding polyester stents. Gastrointest Endosc. 2005 Jun:61(7):891–6.PubMedCrossRef Schubert D, Scheidbach H, Kuhn R et al. Endoscopic treatment of thoracic esophageal anastomotic leaks by using silicone-covered, self-expanding polyester stents. Gastrointest Endosc. 2005 Jun:61(7):891–6.PubMedCrossRef
13.
go back to reference Langer FB, Wenzl E, Prager G et al. Management of postoperative esophageal leaks with the Polyflex self-expanding covered plastic stent. Ann Thorac Surg. 2005 Feb:79(2):398–403.PubMedCrossRef Langer FB, Wenzl E, Prager G et al. Management of postoperative esophageal leaks with the Polyflex self-expanding covered plastic stent. Ann Thorac Surg. 2005 Feb:79(2):398–403.PubMedCrossRef
14.
go back to reference Kauer WK, Stein HJ et al. Stent implantation as a treatment option in patients with thoracic anastomotic leaks after esophagectomy. Surg Endosc. 2008 Jan:22(1):50–3.PubMedCrossRef Kauer WK, Stein HJ et al. Stent implantation as a treatment option in patients with thoracic anastomotic leaks after esophagectomy. Surg Endosc. 2008 Jan:22(1):50–3.PubMedCrossRef
15.
go back to reference Zisis C, Guillin A, Heyries L, et al. Stent placement in the management of oesophageal leaks. Eur J Cardiothorac Surg 2008;33:451–456.PubMedCrossRef Zisis C, Guillin A, Heyries L, et al. Stent placement in the management of oesophageal leaks. Eur J Cardiothorac Surg 2008;33:451–456.PubMedCrossRef
16.
go back to reference Tuebergen D, Rijcken E, Mennigen R, et al. Treatment of thoracic esophageal anastomotic leaks and esophageal perforations with endoluminal stents: efficacy and current limitations. J Gastrointest Surg 2008;12:1168–1176.PubMedCrossRef Tuebergen D, Rijcken E, Mennigen R, et al. Treatment of thoracic esophageal anastomotic leaks and esophageal perforations with endoluminal stents: efficacy and current limitations. J Gastrointest Surg 2008;12:1168–1176.PubMedCrossRef
17.
go back to reference Dai YY, Gretschel S et al. Treatment of oesophageal anastomotic leaks by temporary stenting with self-expanding plastic stents. Br J Surg. 2009 Aug:96(8):887–91.PubMedCrossRef Dai YY, Gretschel S et al. Treatment of oesophageal anastomotic leaks by temporary stenting with self-expanding plastic stents. Br J Surg. 2009 Aug:96(8):887–91.PubMedCrossRef
18.
go back to reference Martin-Smith JD, Larkin JO, O’Connell F, et al. Management of gastro-bronchial fistula complicating a subtotal esophagectomy: a case report. BMS Surg 2009;24:9–20. Martin-Smith JD, Larkin JO, O’Connell F, et al. Management of gastro-bronchial fistula complicating a subtotal esophagectomy: a case report. BMS Surg 2009;24:9–20.
19.
go back to reference Nardella JE, Van Raemdonck D, Pieseevaux H, et al. Gastro-tracheal fistula—unusual and life threatening complication after esophagectomy for cancer: a case report. J Cardiothorac Surg 2009;4:69.PubMedCrossRef Nardella JE, Van Raemdonck D, Pieseevaux H, et al. Gastro-tracheal fistula—unusual and life threatening complication after esophagectomy for cancer: a case report. J Cardiothorac Surg 2009;4:69.PubMedCrossRef
20.
go back to reference Marulli G, Bardini R, Bortolotti L, et al. Repair of a postesophagectomy bronchogastric tube fistula with polyglactin mesh supported with a muscle flap. Ann Thorac Surg 2009;88:1698–1700.PubMedCrossRef Marulli G, Bardini R, Bortolotti L, et al. Repair of a postesophagectomy bronchogastric tube fistula with polyglactin mesh supported with a muscle flap. Ann Thorac Surg 2009;88:1698–1700.PubMedCrossRef
Metadata
Title
Management of Gastrointestinal Leaks After Minimally Invasive Esophagectomy: Conventional Treatments vs. Endoscopic Stenting
Authors
Ninh T. Nguyen
Patrick Donohue Rudersdorf
Brian R. Smith
Kevin Reavis
Xuan-Mai T. Nguyen
Michael J. Stamos
Publication date
01-11-2011
Publisher
Springer-Verlag
Published in
Journal of Gastrointestinal Surgery / Issue 11/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-011-1658-8

Other articles of this Issue 11/2011

Journal of Gastrointestinal Surgery 11/2011 Go to the issue