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Published in: Archives of Osteoporosis 1/2019

Open Access 01-12-2019 | Mammography | Original Article

Primary screening for increased fracture risk by the FRAX® questionnaire—uptake rates in relation to invitation method

Authors: Louise M. E. Moberg, Peter M. Nilsson, Anna H. Holmberg, Göran Samsioe, Christer Borgfeldt

Published in: Archives of Osteoporosis | Issue 1/2019

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Abstract

Summary

The aim of the study was to evaluate the feasibility and most efficient way of offering middle-aged Swedish women a primary fracture screening program via a questionnaire. Two out of five invited women returned the FRAX questionnaire and those contacted directly by mail were most prone to respond.

Purpose

Osteoporosis and its associated fractures are increasing, and this study aims to explore ways to identify women at an increased risk of fracture using the FRAX® algorithm.

Methods

Three thousand middle-aged women were invited and presented a questionnaire distributed by three different methods–by mail, at routine mammography, or internet-based.

Results

In total, 1120 (37.3%) women responded to the questionnaire and agreed to participate. The response rates for the mail, mammography, and internet-based groups were 39.1%, 35.7%, and 25.2% respectively. Women in the mammography group weighed more, were slightly older than the other women, and also had a higher BMI than women from the mail and internet-based groups. No difference was observed between the groups regarding previous fracture, family history for fracture, current smoking, glucocorticoid use, and alcohol usage. The mammography group had a higher median (interquartile range) major osteoporotic FRAX® score (10.0% (7.8–17.0)) than the mail group (9.7% (7.1–15.0); p = 0.005) and the internet-based group (8.7% (6.7–14.0); p = 0.001).

Conclusions

Two out of five early postmenopausal women returned the questionnaire and women contacted directly by mail were more prone to respond. Out of the participants, 26.6% had a 10-year fracture risk score ≥ 15% according to the FRAX® algorithm.
Literature
1.
go back to reference Rosengren BE, Karlsson MK (2014) The annual number of hip fractures in Sweden will double from year 2002 to 2050: projections based on local and nationwide data. Acta Orthop 85:234–237CrossRef Rosengren BE, Karlsson MK (2014) The annual number of hip fractures in Sweden will double from year 2002 to 2050: projections based on local and nationwide data. Acta Orthop 85:234–237CrossRef
2.
go back to reference Marques A, Ferreira RJ, Santos E, Loza E, Carmona L, da Silva JA (2015) The accuracy of osteoporotic fracture risk prediction tools: a systematic review and meta-analysis. Ann Rheum Dis 74:1958–1967CrossRef Marques A, Ferreira RJ, Santos E, Loza E, Carmona L, da Silva JA (2015) The accuracy of osteoporotic fracture risk prediction tools: a systematic review and meta-analysis. Ann Rheum Dis 74:1958–1967CrossRef
3.
go back to reference Kanis JA, McCloskey E, Johansson H, Oden A, Leslie WD (2012) FRAX((R)) with and without bone mineral density. Calcif Tissue Int 90:1–13CrossRef Kanis JA, McCloskey E, Johansson H, Oden A, Leslie WD (2012) FRAX((R)) with and without bone mineral density. Calcif Tissue Int 90:1–13CrossRef
4.
go back to reference Shepstone L, Fordham R, Lenaghan E, Harvey I, Cooper C, Gittoes N, Heawood A, Peters TJ, O’Neill T, Torgerson D, Holland R, Howe A, Marshall T, Kanis JA, McCloskey E (2012) A pragmatic randomised controlled trial of the effectiveness and cost-effectiveness of screening older women for the prevention of fractures: rationale, design and methods for the SCOOP study. Osteoporosis International 23:2507–2515 Shepstone L, Fordham R, Lenaghan E, Harvey I, Cooper C, Gittoes N, Heawood A, Peters TJ, O’Neill T, Torgerson D, Holland R, Howe A, Marshall T, Kanis JA, McCloskey E (2012) A pragmatic randomised controlled trial of the effectiveness and cost-effectiveness of screening older women for the prevention of fractures: rationale, design and methods for the SCOOP study. Osteoporosis International 23:2507–2515
5.
go back to reference Shepstone L, Lenaghan E, Cooper C et al (2017) Screening in the community to reduce fractures in older women (SCOOP): a randomised controlled trial. Lancet (London, England) Shepstone L, Lenaghan E, Cooper C et al (2017) Screening in the community to reduce fractures in older women (SCOOP): a randomised controlled trial. Lancet (London, England)
6.
go back to reference Rubin KH, Holmberg T, Rothmann MJ, Høiberg M, Barkmann R, Gram J, Hermann AP, Bech M, Rasmussen O, Glüer CC, Brixen K (2015) The risk-stratified osteoporosis strategy evaluation study (ROSE): a randomized prospective population-based study. Design and baseline characteristics. Calcif Tissue Int 96:167–179CrossRef Rubin KH, Holmberg T, Rothmann MJ, Høiberg M, Barkmann R, Gram J, Hermann AP, Bech M, Rasmussen O, Glüer CC, Brixen K (2015) The risk-stratified osteoporosis strategy evaluation study (ROSE): a randomized prospective population-based study. Design and baseline characteristics. Calcif Tissue Int 96:167–179CrossRef
7.
go back to reference Rubin KH, Rothmann MJ, Holmberg T et al (2017) Effectiveness of a two-step population-based osteoporosis screening program using FRAX: the randomized risk-stratified Osteoporosis Strategy Evaluation (ROSE) study. Osteoporosis International Rubin KH, Rothmann MJ, Holmberg T et al (2017) Effectiveness of a two-step population-based osteoporosis screening program using FRAX: the randomized risk-stratified Osteoporosis Strategy Evaluation (ROSE) study. Osteoporosis International
9.
go back to reference Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet (London, England) 359:1761–1767CrossRef Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet (London, England) 359:1761–1767CrossRef
10.
go back to reference Kanis JA, Hans D, Cooper C et al (2011) Interpretation and use of FRAX in clinical practice. Osteoporosis International 22:2395–2411 Kanis JA, Hans D, Cooper C et al (2011) Interpretation and use of FRAX in clinical practice. Osteoporosis International 22:2395–2411
15.
go back to reference Arbyn M, Smith SB, Temin S, Sultana F, Castle P, Collaboration on S-S, Testing HPV (2018) Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses. BMJ (Clinical Research ed) 363:k4823 Arbyn M, Smith SB, Temin S, Sultana F, Castle P, Collaboration on S-S, Testing HPV (2018) Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses. BMJ (Clinical Research ed) 363:k4823
16.
go back to reference Lagerlund M, Drake I, Wirfalt E, Sontrop JM, Zackrisson S (2015) Health-related lifestyle factors and mammography screening attendance in a Swedish cohort study. Eur J Cancer Prev 24:44–50 Lagerlund M, Drake I, Wirfalt E, Sontrop JM, Zackrisson S (2015) Health-related lifestyle factors and mammography screening attendance in a Swedish cohort study. Eur J Cancer Prev 24:44–50
17.
go back to reference Manjer AR, Emilsson UM, Zackrisson S (2015) Non-attendance in mammography screening and women’s social network: a cohort study on the influence of family composition, social support, attitudes and cancer in close relations. World J Surg Oncol 13:211 Manjer AR, Emilsson UM, Zackrisson S (2015) Non-attendance in mammography screening and women’s social network: a cohort study on the influence of family composition, social support, attitudes and cancer in close relations. World J Surg Oncol 13:211
18.
go back to reference Rothmann MJ, Huniche L, Ammentorp J, Barkmann R, Gluer CC, Hermann AP (2014) Women’s perspectives and experiences on screening for osteoporosis (Risk-stratified Osteoporosis Strategy Evaluation, ROSE). Arch Osteoporos 9:192CrossRef Rothmann MJ, Huniche L, Ammentorp J, Barkmann R, Gluer CC, Hermann AP (2014) Women’s perspectives and experiences on screening for osteoporosis (Risk-stratified Osteoporosis Strategy Evaluation, ROSE). Arch Osteoporos 9:192CrossRef
19.
go back to reference Edwards P, Roberts I, Clarke M, DiGuiseppi C, Pratap S, Wentz R, Kwan I (2002) Increasing response rates to postal questionnaires: systematic review. BMJ (Clinical research ed) 324:1183CrossRef Edwards P, Roberts I, Clarke M, DiGuiseppi C, Pratap S, Wentz R, Kwan I (2002) Increasing response rates to postal questionnaires: systematic review. BMJ (Clinical research ed) 324:1183CrossRef
Metadata
Title
Primary screening for increased fracture risk by the FRAX® questionnaire—uptake rates in relation to invitation method
Authors
Louise M. E. Moberg
Peter M. Nilsson
Anna H. Holmberg
Göran Samsioe
Christer Borgfeldt
Publication date
01-12-2019
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2019
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-019-0603-4

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