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World Journal of Urology

Published in:

01-02-2014 | Original Article

Malondialdehyde and CA II autoantibody levels are elevated in children with undescended testes

Authors: Ahmet Alver, Mustafa İmamoğlu, Ahmet Menteşe, Ayşe Şentürk, Serap Samut Bülbül, Cemil Kahraman, Ayşegül Sümer

Published in: World Journal of Urology | Issue 1/2014

Abstract

Purpose

In the pathogenesis of sub-fertility/infertility and testicular cancer related to undescended testes, oxidative stress, inflammation and autoimmunity are important factors. Therefore, the present study was designed to determine serum oxidative stress markers and carbonic anhydrase (CA) II autoantibodies in boys with undescended testes (UDT), and to investigate the relationship between these parameters.

Methods

Serum CA II autoantibody titers, malondialdehyde (MDA), ischemia modified albumin (IMA), protein carbonyl content and soluble CD40 ligand (sCD40L) levels were measured in 59 boys with UDT and 30 healthy subjects.

Results

MDA levels were significantly higher in the UDT group compared with the control group (p = 0.003). There was no significant difference between serum IMA, sCD40L or protein carbonyl levels. CA II autoantibody titers in the UDT group were significantly higher compared with those of the control group (p = 0.048). A weak positive correlation was determined between anti-CA II antibody titers and MDA and IMA levels (p = 0.041, p = 0.005, respectively).

Conclusions

MDA is the most reliable and decisive biochemical marker displaying oxidative damage in undescended testes, and an autoimmune response may be triggered by oxidative stress against CA II during the UDT process.

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Title: Malondialdehyde and CA II autoantibody levels are elevated in children with undescended testes
Authors: Ahmet Alver
Mustafa İmamoğlu
Ahmet Menteşe
Ayşe Şentürk
Serap Samut Bülbül
Cemil Kahraman
Ayşegül Sümer
Publication date: 01-02-2014
Publisher: Springer Berlin Heidelberg
Published in: World Journal of Urology / Issue 1/2014
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-013-1129-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Malondialdehyde and CA II autoantibody levels are elevated in children with undescended testes

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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