Top

Child's Nervous System

Published in:

01-02-2006 | Case Report

Malignant meningioma as a second malignancy after therapy for acute lymphatic leukemia without cranial radiation

Authors: J. P. Regel, B. Schoch, I. E. Sandalcioglu, R. Wieland, C. Westermeier, D. Stolke, H. Wiedemayer

Published in: Child's Nervous System | Issue 2/2006

Abstract

Rationale

Meningiomas in the pediatric age group are very rare tumors, comprising about 1–4.2% of all primary pediatric intracranial tumors.

Case report

We present a 17-year-old patient who suffered from an intraventricular malignant meningioma. At the age of 2 years, acute lymphatic leukemia (common ALL [cALL]) was diagnosed and successfully treated with chemotherapy. There was no cranial radiation therapy.

In December 2001, 13 years after diagnosis of cALL, he complained of headache, vomiting, and walking difficulties. Magnetic resonance imaging showed an enhancing mass with cystic components in the trigone of the right lateral ventricle. The tumor was removed completely. Histological diagnosis revealed a malignant papillary meningioma. After removal of a recurrent meningioma 16 months later, he received local radiotherapy.

Conclusion

Pathogenetic mechanisms, treatment options, and prognosis of meningiomas and secondary malignancies of this age group are discussed.

Amirjamshidi A, Mehrazin M, Abbassioun K (2000) Meningiomas of the central nervous system occurring below the age of 17: report of 24 cases not associated with neurofibromatosis and review of literature. Childs Nerv Syst 16:406–416PubMed

Bhatia S, Sather HN, Pabustan OB et al (2002) Low incidence of second neoplasms among children diagnosed with acute lymphoblastic leukemia after 1983. Blood 99:4257–4264PubMed

Blay JY, Conroy T, Chevreau C et al (1998) High-dose methotrexate for the treatment of primary cerebral lymphomas: analysis of survival and late neurologic toxicity in a retrospective series. J Clin Oncol 16:864–871PubMed

Brenner DJ, Elliston CD, Hall EJ, Berdon WE (2001) Estimates of the cancer risks from pediatric CT radiation are not merely theoretical: comment on point/counterpoint: in x-ray computed tomography, technique factors should be selected appropriate to patient size. against the proposition. Med Phys 28:2387–2388PubMed

Carra S, Drigo P, Gardiman M et al (2001) Clear-cell meningioma in a 22-month-old male: a case report and literature review. Pediatr Neurosurg 34:264–267PubMed

Doty JR, Schut L, Bruce DA, Sutton LN (1987) Intracranial meningiomas of childhood and adolescence. Prog Exp Tumor Res 30:247–254

Hojo H, Abe M (2001) Rhabdoid papillary meningioma. Am J Surg Pathol 25:964–969PubMed

Im SH, Wang KC, Kim SK et al (2001) Childhood meningioma: unusual location, atypical radiological findings, and favorable treatment outcome. Childs Nerv Syst 17:656–662CrossRefPubMed

Iuvone L, Mariotti P, Colosimo C et al (2002) Long-term cognitive outcome, brain computed tomography scan, and magnetic resonance imaging in children cured for acute lymphoblastic leukemia. Cancer 95:2562–2570PubMed

10.

Kohama I, Sohma T, Nunomura K et al (1996) Intraparenchymal meningioma in an infant-case report. Neurol Med Chir (Tokyo) 36:598–601

Title: Malignant meningioma as a second malignancy after therapy for acute lymphatic leukemia without cranial radiation
Authors: J. P. Regel
B. Schoch
I. E. Sandalcioglu
R. Wieland
C. Westermeier
D. Stolke
H. Wiedemayer
Publication date: 01-02-2006
Publisher: Springer-Verlag
Published in: Child's Nervous System / Issue 2/2006
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-005-1143-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Malignant meningioma as a second malignancy after therapy for acute lymphatic leukemia without cranial radiation

Abstract

Rationale

Case report

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Rationale

Case report

Conclusion

Please log in to get access to this content

Other articles of this Issue 2/2006

“Conservative” surgical approach and early postoperative radiotherapy in a patient with a huge cystic craniopharyngioma

Successful treatment of multiple Pseudallescheria boydii brain abscesses and ventriculitis/ependymitis in a 2-year-old child after a near-drowning episode

Short-term dexamethasone treatment

“Conservative” surgical approach and early postoperative radiotherapy in a patient with a huge cystic craniopharyngioma

Spontaneous resolution of isolated Chiari I malformation

XX Biennial Congress of the European Society for Pediatric Neurosurery, 6-11 March 2006, Martinique