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American Journal of Clinical Dermatology

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01-06-2018 | Review Article

Malignancy Risk and Recurrence with Psoriasis and its Treatments: A Concise Update

Authors: Shamir Geller, Haoming Xu, Mark Lebwohl, Beatrice Nardone, Mario E. Lacouture, Meenal Kheterpal

Published in: American Journal of Clinical Dermatology | Issue 3/2018

Abstract

Psoriasis is a common inflammatory cutaneous disease that affects approximately 120 million people worldwide. Systemic treatments have significantly improved disease burden, but concerns persist regarding their association with increased risk of malignancy. Patients with psoriasis have a slightly elevated baseline risk of lymphoproliferative diseases. Studies on methotrexate and cyclosporine, as well as older biological agents such as tumor necrosis factor inhibitors, have found no increased risk of non-cutaneous solid tumors; however, positive associations between cutaneous squamous cell carcinomas and certain therapies have been found. There is conflicting evidence regarding the risk of lymphoma and melanoma. Further studies are needed to determine the long-term safety of newer psoriasis treatments (interleukin [IL]-12/23, IL-17, Janus kinase 1/3, and phosphodiesterase-4 inhibitors), specifically their safety in patients with a history of cancer. This review summarizes the most recent studies on malignancy risk from psoriasis, and its treatments in patients and cancer survivors, with the highest available level of evidence.

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Title: Malignancy Risk and Recurrence with Psoriasis and its Treatments: A Concise Update
Authors: Shamir Geller
Haoming Xu
Mark Lebwohl
Beatrice Nardone
Mario E. Lacouture
Meenal Kheterpal
Publication date: 01-06-2018
Publisher: Springer International Publishing
Published in: American Journal of Clinical Dermatology / Issue 3/2018
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI: https://doi.org/10.1007/s40257-017-0337-2

At a glance: The STEP trials

Springer Medicine

Malignancy Risk and Recurrence with Psoriasis and its Treatments: A Concise Update

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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