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Journal of Assisted Reproduction and Genetics

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01-07-2010 | Genetics

Male infertility in China: laboratory finding for AZF microdeletions and chromosomal abnormalities in infertile men from Northeastern China

Authors: Rui-Xue Wang, Chao Fu, Ya-Ping Yang, Rong-Rong Han, Yuan Dong, Ru-Lin Dai, Rui-Zhi Liu

Published in: Journal of Assisted Reproduction and Genetics | Issue 7/2010

Abstract

Purposes

To investigate the frequencies of AZF microdeletions and chromosomal abnormalities in infertile men from Northeastern China. Moreover, to compare the prevalence of these abnormalities with other countries and regions in the world.

Methods

305 infertile men were enrolled. A complete semen analysis and reproductive hormones were measured according to standard methods. Multiplex polymerase chain reaction (PCR) amplification using nine specific sequence-tagged sites (STS) were used to detect AZF microdeletions. Karyotype analyses were performed on peripheral blood lymphocytes with standard G-banding.

Results

Of the 305 infertile men, 28 (9.2%) had AZF microdeletions and 26 (8.5%) had chromosomal abnormalities. The most frequent microdeletions were in the AZFc+d, followed by AZFc, AZFb+c+d and AZFa. A total of 19 patients (82.6%) had Klinefelter′s syndrome (47, XXY) in the azoospermic group.

Conclusions

The freqencies of AZF microdeletions and chromosomal abnormalities in infertile men from Northeastern China were comparable with infertile men from other countries and regions. However, there was a slightly higher prevalence rate of AZF microdeletions in oligozoospermic patients than reported in previous studies.

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Title: Male infertility in China: laboratory finding for AZF microdeletions and chromosomal abnormalities in infertile men from Northeastern China
Authors: Rui-Xue Wang
Chao Fu
Ya-Ping Yang
Rong-Rong Han
Yuan Dong
Ru-Lin Dai
Rui-Zhi Liu
Publication date: 01-07-2010
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 7/2010
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-010-9420-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Male infertility in China: laboratory finding for AZF microdeletions and chromosomal abnormalities in infertile men from Northeastern China

Abstract

Purposes

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purposes

Methods

Results

Conclusions

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