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BMC Complementary Medicine and Therapies

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Open Access 01-12-2023 | Malaria | Research

Efficacy of artesunate combined with Atractylodes lancea or Prabchompoothaweep remedy extracts as adjunctive therapy for the treatment of cerebral malaria

Authors: Walaiporn Plirat, Prapaporn Chaniad, Arisara Phuwajaroanpong, Atthaphon Konyanee, Parnpen Viriyavejakul, Abdi Wira Septama, Chuchard Punsawad

Published in: BMC Complementary Medicine and Therapies | Issue 1/2023

Abstract

Background

Cerebral malaria is one of the most serious complications of Plasmodium infection and causes behavioral changes. However, current antimalarial drugs have shown poor outcomes. Therefore, new antimalarials with neuroprotective effects are urgently needed. This study aimed to evaluate the effects of selected extracts as monotherapy or adjunctive therapy with artesunate on antimalarial, anti-inflammatory, antioxidant, and neuroprotective properties in experimental cerebral malaria (ECM).

Methods

ECM was induced in male C57BL/6 mice by infection with Plasmodium berghei ANKA (PbA). Ethanolic extracts of Atractylodes lancea (a dose of 400 mg/kg) and Prabchompoothaweep remedy (a dose of 600 mg/kg) were evaluated as monotherapy and adjunctive therapy combined with artesunate at the onset of signs of cerebral malaria and continued for 7 consecutive days. Parasitemia, clinical scores, and body weight were recorded throughout the study. At day 13 post-infection, mouse brains were dissected and processed for the study of the inflammatory response, oxidative stress, blood–brain barrier (BBB) integrity, histopathological changes, and neurocognitive impairments.

Results

Ethanolic extracts of A. lancea and Prabchompoothaweep remedy alone improved cerebral malaria outcome in ECM, whereas artesunate combined with extracts of A. lancea or Prabchompoothaweep remedy significantly improved the outcome of artesunate and crude extracts alone. Using real-time PCR, PbA-infected mice that had received the combination treatment showed significantly reduced gene expression of inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-10), chemokines (CXCL4 and CXCL10), and adhesion molecules (ICAM-1, VCAM1, and CD36). The PbA-infected mice that received the combination treatment showed a significantly decreased malondialdehyde level compared to the untreated group. Similarly, the Evans blue dye assay revealed significantly less dye extravasation in the brains of infected mice administered the combination treatment, indicating improved BBB integrity. Combination treatment improved survival and reduced pathology in the PbA-infected group. Additionally, combination treatment resulted in a significantly reduced level of cognitive impairment, which was analyzed using a novel object recognition test.

Conclusions

This study demonstrated that artesunate combined with A. lancea or Prabchompoothaweep remedy extracts as adjunctive therapy reduced mortality, neuroinflammation, oxidative stress, BBB integrity protection, and neurocognitive impairment in the ECM.

Varo R, Chaccour C, Bassat Q. Update on malaria. Med Clin (Barc). 2020;155(9):395–402. https://doi.org/10.1016/j.medcli.2020.05.010.CrossRefPubMed

WHO. World malaria report. [cited 2023 2]. Available from: https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2022.

Oluwayemi IO, Brown BJ, Oyedeji OA, Oluwayemi MA. Neurological sequelae in survivors of cerebral malaria. Pan Afr Med J. 2013;15(1):88.PubMedPubMedCentral

Zhao S, Duan H, Yang Y, Yan X, Fan K. Fenozyme protects the integrity of the blood–brain barrier against experimental cerebral malaria. Nano Lett. 2019;19(12):8887–95.CrossRefPubMed

John CC, Bangirana P, Byarugaba J, Opoka RO, Idro R, Jurek AM, Wu B, Boivin MJ. Cerebral malaria in children is associated with long-term cognitive impairment. Pediatrics. 2008;122(1):e92–9. https://doi.org/10.1542/peds.2007-3709.CrossRefPubMed

Idro R, Kakooza-Mwesige A, Asea B, Ssebyala K, Bangirana P, Opoka RO, Lubowa SK, Semrud-Clikeman M, John CC, Nalugya J. Cerebral malaria is associated with long-term mental health disorders: a cross sectional survey of a long-term cohort. Malar J. 2016;15(1):1–11.CrossRef

Odhiambo OC, Wamakima HN, Magoma GN, Kirira PG, Malala BJ, Kimani FT, Muregi FW. Efficacy and safety evaluation of a novel trioxaquine in the management of cerebral malaria in a mouse model. Malar J. 2017;16(1):268. https://doi.org/10.1186/s12936-017-1917-6.CrossRefPubMedPubMedCentral

Wilson DW, Langer C, Goodman CD, McFadden GI, Beeson JG. Defining the timing of action of antimalarial drugs against Plasmodium falciparum. Antimicrob Agents Chemother. 2013;57(3):1455–67. https://doi.org/10.1128/aac.01881-12.CrossRefPubMedPubMedCentral

Luzolo AL, Ngoyi DM. Cerebral malaria. Brain Res Bull. 2019;145:53–8.CrossRefPubMed

10.

Datta D, Conroy AL, Castelluccio PF, Ssenkusu JM, Park GS, Opoka RO, Bangirana P, Idro R, Saykin AJ, John CC. Elevated cerebrospinal fluid tau protein concentrations on admission are associated with long-term neurologic and cognitive impairment in Ugandan children with cerebral malaria. Clin Infect Dis. 2020;70(6):1161–8.CrossRefPubMed

11.

Langfitt JT, McDermott MP, Brim R, Mboma S, Potchen MJ, Kampondeni SD, Seydel KB, Semrud-Clikeman M, Taylor TE. Neurodevelopmental impairments 1 year after cerebral malaria. Pediatrics. 2019;143(2):e20181026.CrossRefPubMed

12.

Idro R, Marsh K, John CC, Newton CR. Cerebral malaria: mechanisms of brain injury and strategies for improved neurocognitive outcome. Pediatr Res. 2010;68(4):267–74.CrossRefPubMedPubMedCentral

13.

Pace AA, Edwards S, Weatherby S. A new clinical variant of the post-malaria neurological syndrome. J Neurol Sci. 2013;334(1–2):183–5.CrossRefPubMed

14.

Woodrow CJ, White NJ. The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread. FEMS Microbiol Rev. 2017;41(1):34–48.CrossRefPubMedPubMedCentral

15.

Alehegn AA, Yesuf JS, Birru EM. Antimalarial activity of crude extract and solvent fractions of the leaves of Bersama abyssinica fresen. (Melianthaceae) against Plasmodium berghei infection in Swiss albino mice. Evid Based Complementary Altern Med. 2020;2020:9467359.

16.

Mojab F. Antimalarial natural products: a review. Avicenna J Phytomedicine. 2012;2(2):52.

17.

Mina PR, Kumar S, Agarwal K, Kumar R, Pal A, Tandon S, Yadav SK, Yadav S, Darokar MP. 4-chloro eugenol interacts synergistically with artesunate against drug resistant P. falciparum inducing oxidative stress. Biomed Pharmacother. 2021;137:111311. https://doi.org/10.1016/j.biopha.2021.111311.CrossRefPubMed

18.

Crowley VM, Ayi K, Lu Z, Liby KT, Sporn M, Kain KC. Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria. Malar J. 2017;16(1):1–11.CrossRef

19.

Jiang X, Chen L, Zheng Z, Chen Y, Weng X, Guo Y, Li K, Yang T, Qu S, Liu H, et al. Synergistic effect of combined artesunate and tetramethylpyrazine in experimental cerebral malaria. ACS Infect Dis. 2020;6(9):2400–9. https://doi.org/10.1021/acsinfecdis.0c00124.CrossRefPubMed

20.

Walter NS, Gorki V, Chauhan M, Dhingra N, Kaur S. Sinigrin in combination with artesunate provides protection against lethal murine malaria via falcipain-3 inhibition and immune modulation. Int Immunopharmacol. 2021;101(Pt A):108320. https://doi.org/10.1016/j.intimp.2021.108320.CrossRefPubMed

21.

Onthong N, Chonpatathip U, Rajanivat Y, Patthananurak K, Sangvichien S, Kamoltham T. A comparative study on the effects of Prabchompoothaweep remedy and loratadine in treatment of patients with allergic rhinitis and upper respiratory tract infections at Pathumtani hospital. J Health Educ. 2019;42(1):135–45.

22.

Leangpanich S, Itharat A, Chanvimalueng W, Mukkasombat N. A preliminary study on efficacy of Prapchompoothaweep remedy for treatment of allergic rhinitis patients and their quality of life after the treatment. TMJ. 2019;19(3):537–46.

23.

Jai-aue AMS, Juckmeta T, Itharat A. Anti-allergic, anti-inflammatory and antioxidant activities of the different extracts of Thai traditional remedy called prabchompoothaweep for allergic rhinitis treatment. J Med Assoc Thai=Chotmaihet Thangphaet. 2014;97:1401488.

24.

Chaniad P, Techarang T, Phuwajaroanpong A, Plirat W, Viriyavejakul P, Septama AW, Punsawad C. Antimalarial efficacy and toxicological assessment of medicinal plant ingredients of Prabchompoothaweep remedy as a candidate for antimalarial drug development. BMC Complement Med Ther. 2023;23(1):12. https://doi.org/10.1186/s12906-023-03835-x.CrossRefPubMedPubMedCentral

25.

Plirat W, Chaniad P, Phuwajaroanpong A, Septama AW, Punsawad C. Phytochemical, antimalarial, and acute oral toxicity properties of selected crude extracts of prabchompoothaweep remedy in Plasmodium berghei-infected mice. Trop Med Infect Dis. 2022;7(12):395.CrossRefPubMedPubMedCentral

26.

Zhang WJ, Zhao ZY, Chang LK, Cao Y, Wang S, Kang CZ, Wang HY, Zhou L, Huang LQ, Guo LP. Atractylodis Rhizoma: A review of its traditional uses, phytochemistry, pharmacology, toxicology and quality control. J Ethnopharmacol. 2021;266:113415. https://doi.org/10.1016/j.jep.2020.113415.CrossRefPubMed

27.

Na-Bangchang K, Kulma I, Plengsuriyakarn T, Tharavanij T, Kotawng K, Chemung A, Muhamad N, Karbwang J. Phase I clinical trial to evaluate the safety and pharmacokinetics of capsule formulation of the standardized extract of Atractylodes lancea. J Tradit Complement Med. 2021;11(4):343–55. https://doi.org/10.1016/j.jtcme.2021.02.002.CrossRefPubMedPubMedCentral

28.

Ishii T, Okuyama T, Noguchi N, Nishidono Y, Okumura T, Kaibori M, Tanaka K, Terabayashi S, Ikeya Y, Nishizawa M. Antiinflammatory constituents of Atractylodes chinensis rhizome improve glomerular lesions in immunoglobulin a nephropathy model mice. J Nat Med. 2020;74(1):51–64. https://doi.org/10.1007/s11418-019-01342-3.CrossRefPubMed

29.

Kulma I, Panrit L, Plengsuriyakarn T, Chaijaroenkul W, Warathumpitak S, Na-Bangchang K. A randomized placebo-controlled phase I clinical trial to evaluate the immunomodulatory activities of Atractylodes lancea (Thunb) DC. in healthy Thai subjects. BMC Complement Med Ther. 2021;21(1):61. https://doi.org/10.1186/s12906-020-03199-6.CrossRefPubMedPubMedCentral

30.

Yusuf FH, Hafiz MY, Shoaib M, Ahmed SA. Cerebral malaria: insight into pathogenesis, complications and molecular biomarkers. Infect Drug Resist. 2017;10:57–9. https://doi.org/10.2147/idr.S125436.CrossRefPubMedPubMedCentral

31.

Gull I, Javed A, Aslam MS, Mushtaq R, Athar MA. Use of Moringa oleifera flower pod extract as natural preservative and development of SCAR marker for its DNA based identification. Biomed Res Int. 2016;2016:7584318. https://doi.org/10.1155/2016/7584318.CrossRefPubMedPubMedCentral

32.

Qu W, Breksa Iii AP, Pan Z, Ma H, McHugh TH. Storage stability of sterilized liquid extracts from pomegranate peel. J Food Sci. 2012;77(7):C765–72. https://doi.org/10.1111/j.1750-3841.2012.02779.x.CrossRefPubMed

33.

Carroll RW, Wainwright MS, Kim K-Y, Kidambi T, Gómez ND, Taylor T, Haldar K. A rapid murine coma and behavior scale for quantitative assessment of murine cerebral malaria. PLOS ONE. 2010;5(10):e13124. https://doi.org/10.1371/journal.pone.0013124.CrossRefPubMedPubMedCentral

34.

Camara A, Haddad M, Reybier K, Traoré MS, Baldé MA, Royo J, Baldé AO, Batigne P, Haidara M, Baldé ES, et al. Terminalia albida treatment improves survival in experimental cerebral malaria through reactive oxygen species scavenging and anti-inflammatory properties. Malar J. 2019;18(1):431. https://doi.org/10.1186/s12936-019-3071-9.CrossRefPubMedPubMedCentral

35.

Cariaco Y, Lima WR, Sousa R, Nascimento LAC, Briceño MP, Fotoran WL, Wunderlich G, Dos Santos JL, Silva NM. Ethanolic extract of the fungus Trichoderma stromaticum decreases inflammation and ameliorates experimental cerebral malaria in C57BL/6 mice. Sci Rep. 2018;8(1):1–15.CrossRef

36.

de Jong EK, de Haas AH, Brouwer N, van Weering HR, Hensens M, Bechmann I, Pratley P, Wesseling E, Boddeke HW, Biber K. Expression of CXCL4 in microglia in vitro and in vivo and its possible signaling through CXCR3. J Neurochem. 2008;105(5):1726–36. https://doi.org/10.1111/j.1471-4159.2008.05267.x.CrossRefPubMed

37.

Du Y, Chen G, Zhang X, Yu C, Cao Y, Cui L. Artesunate and erythropoietin synergistically improve the outcome of experimental cerebral malaria. Int Immunopharmacol. 2017;48:219–30. https://doi.org/10.1016/j.intimp.2017.05.008.CrossRefPubMed

38.

Techarang T, Jariyapong P, Viriyavejakul P, Punsawad C. High mobility group box-1 (HMGB-1) and its receptors in the pathogenesis of malaria-associated acute lung injury/acute respiratory distress syndrome in a mouse model. Heliyon. 2021;7(12):e08589.CrossRefPubMedPubMedCentral

39.

Punsawad C, Maneerat Y, Chaisri U, Nantavisai K, Viriyavejakul P. Nuclear factor kappa B modulates apoptosis in the brain endothelial cells and intravascular leukocytes of fatal cerebral malaria. Malar J. 2013;12(1):260. https://doi.org/10.1186/1475-2875-12-260.CrossRefPubMedPubMedCentral

40.

Chaniad P, Techarang T, Phuwajaroanpong A, Punsawad C. Antimalarial activity and toxicological assessment of Betula alnoides extract against Plasmodium berghei infections in mice. Evid Based Complementary Altern Med. 2019;2019:2324679.CrossRef

41.

Kim H, Erdman LK, Lu Z, Serghides L, Zhong K, Dhabangi A, Musoke C, Gerard C, Cserti-Gazdewich C, Liles WC, et al. Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria. Infect Immun. 2014;82(1):371–9. https://doi.org/10.1128/iai.01246-13.CrossRefPubMedPubMedCentral

42.

Lueptow LM. Novel object recognition test for the investigation of learning and memory in mice. J Visual Exper 2017(126). https://doi.org/10.3791/55718

43.

Bevins RA, Besheer J. Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study “recognition memory.” Nat Protoc. 2006;1(3):1306–11. https://doi.org/10.1038/nprot.2006.205.CrossRefPubMed

44.

Engwerda C, Belnoue E, Grüner AC, Rénia L. Experimental models of cerebral malaria. Immunol Immunopathog Malaria. 2005;297:103–43.CrossRef

45.

Ouko DB, Amwayi PW, Ochola LA, Wairagu PM, Isaac AO, Nyariki JN. Co-administration of chloroquine and coenzyme Q10 improved treatment outcome during experimental cerebral malaria. J Parasit Dis. 2022;46(2):466–75. https://doi.org/10.1007/s12639-022-01468-4.CrossRefPubMedPubMedCentral

46.

Valli M, Russo HM, Bolzani VS. The potential contribution of the natural products from Brazilian biodiversity to bioeconomy. An Acad Bras Cienc. 2018;90:763–78.CrossRefPubMed

47.

Jia WJ, Yuan Y, Wu CY. Therapeutic effects of herbal compounds in cerebral ischemia with special reference to suppression of microglia activation implicated in neurodegeneration. Histol Histopathol. 2019;34:965–83.PubMed

48.

Araújo MV, Queiroz AC, Silva JF, Silva AE, Silva JK, Silva GR, Silva EC, Souza ST, Fonseca EJ, Camara CA. Flavonoids induce cell death in Leishmania amazonensis: in vitro characterization by flow cytometry and Raman spectroscopy. Analyst. 2019;144(17):5232–44.CrossRefPubMed

49.

Muema JM, Bargul JL, Njeru SN, Onyango JO, Imbahale SS. Prospects for malaria control through manipulation of mosquito larval habitats and olfactory-mediated behavioural responses using plant-derived compounds. Parasites Vectors. 2017;10(1):1–18.CrossRef

50.

Koonrungsesomboon N, Na-Bangchang K, Karbwang J. Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC. Asian Pac J Trop Med. 2014;7(6):421–8.CrossRefPubMed

51.

Clemmer L, Martins Y, Zanini G, Frangos J, Carvalho L. Artemether and artesunate show the highest efficacies in rescuing mice with late-stage cerebral malaria and rapidly decrease leukocyte accumulation in the brain. Antimicrob Agents Chemother. 2011;55(4):1383–90.CrossRefPubMedPubMedCentral

52.

Mubaraki MA, Hafiz TA, Al-Quraishy S, Dkhil MA. Oxidative stress and genes regulation of cerebral malaria upon Zizyphus spina-christi treatment in a murine model. Microb Pathog. 2017;107:69–74. https://doi.org/10.1016/j.micpath.2017.03.017.CrossRefPubMed

53.

Ungogo MA, Ebiloma GU, Ichoron N, Igoli JO, de Koning HP, Balogun EO. A review of the antimalarial, antitrypanosomal, and antileishmanial activities of natural compounds isolated from Nigerian flora. Front Chem 2020;8. https://doi.org/10.3389/fchem.2020.617448

54.

Mazid M, Khan T, Mohammad F. Role of secondary metabolites in defense mechanisms of plants. Biol Med. 2011;3(2):232–49.

55.

CorrêaSoares JB, Menezes D, Vannier-Santos MA, Ferreira-Pereira A, Almeida GT, Venancio TM, Verjovski-Almeida S, Zishiri VK, Kuter D, Hunter R, et al. Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols. PLOS Negl Trop Dis. 2009;3(7):e477. https://doi.org/10.1371/journal.pntd.0000477.CrossRef

56.

Ja’afar NSA, Nik Mat Zin NNI, Mohamad FS, Abu-Bakar N. A polyphenol, pyrogallol changes the acidic pH of the digestive vacuole of Plasmodium falciparum. Life Sci Med Biomed 2021;5(1). https://doi.org/10.28916/lsmb.5.1.2021.82

57.

Espíndola KMM, Ferreira RG, Narvaez LEM, Silva Rosario ACR, da Silva AHM, Silva AGB, Vieira APO, Monteiro MC. Chemical and pharmacological aspects of caffeic acid and its activity in hepatocarcinoma. Front Oncol. 2019;9:541. https://doi.org/10.3389/fonc.2019.00541.CrossRefPubMedPubMedCentral

58.

Alson SG, Jansen O, Cieckiewicz E, Rakotoarimanana H, Rafatro H, Degotte G, Francotte P, Frederich M. In-vitro and in-vivo antimalarial activity of caffeic acid and some of its derivatives. J Pharm Pharmacol. 2018;70(10):1349–56. https://doi.org/10.1111/jphp.12982.CrossRefPubMed

59.

Lin Y, Shi R, Wang X, Shen HM. Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets. 2008;8(7):634–46. https://doi.org/10.2174/156800908786241050.CrossRefPubMedPubMedCentral

60.

Chaniad P, Phuwajaroanpong A, Plirat W, Techarang T, Chukaew A, Punsawad C. In vivo assessment of the antimalarial activity and acute oral toxicity of an ethanolic seed extract of Spondias pinnata (L.f.) Kurz. BMC Complement Med Ther. 2022;22(1):72. https://doi.org/10.1186/s12906-022-03546-9.CrossRefPubMedPubMedCentral

61.

Matthew AO, Olusola E, Ademola O, Aderotimi A, Adebola J. Anti-malarial activity of total saponins from Terminalia avicennioidesand its effect on liver and haematological of infected mice. Drug Des. 2018;7:1–6. https://doi.org/10.4172/2169-0138.1000161.CrossRef

62.

Soh PN, Witkowski B, Olagnier D, Nicolau ML, Garcia-Alvarez MC, Berry A, Benoit-Vical F. In vitro and in vivo properties of ellagic acid in malaria treatment. Antimicrob Agents Chemother. 2009;53(3):1100–6. https://doi.org/10.1128/aac.01175-08.CrossRefPubMed

63.

Muchtar NH, Nik Mat Zin NNI, Mohamad FS, Abu-Bakar N. Ellagic acid induces in vitro alkalinisation of the digestive vacuole in drug-sensitive Plasmodium falciparum strain. Malays J Med Sci. 2022;29(4):43–52. https://doi.org/10.21315/mjms2022.29.4.5.CrossRefPubMedPubMedCentral

64.

Hora R, Kapoor P, Thind KK, Mishra PC. Cerebral malaria–clinical manifestations and pathogenesis. Metab Brain Dis. 2016;31(2):225–37. https://doi.org/10.1007/s11011-015-9787-5.CrossRefPubMed

65.

Souza TL, Grauncke ACB, Ribeiro LR, Mello FK, Oliveira SM, Brant F, Machado FS, Oliveira MS. Cerebral malaria causes enduring behavioral and molecular changes in mice brain without causing gross histopathological damage. Neurosci. 2018;369:66–75. https://doi.org/10.1016/j.neuroscience.2017.10.043.CrossRef

66.

Reis PA, Estato V, da Silva TI, d’Avila JC, Siqueira LD, Assis EF, Bozza PT, Bozza FA, Tibirica EV, Zimmerman GA. Statins decrease neuroinflammation and prevent cognitive impairment after cerebral malaria. PLoS Pathog. 2012;8(12):e1003099.CrossRefPubMedPubMedCentral

67.

Oliveira KRHM, Torres MLM, Kauffmann N, de AzevedoAtaíde BJ, de Souza Franco Mendes N, Dos Anjos LM, dos Santos Borges R, Bahia CP, Leão LKR, da Conceição Fonseca Passos A. Euterpe oleracea fruit (Açai)-enriched diet suppresses the development of experimental cerebral malaria induced by Plasmodium berghei (ANKA) infection. BMC Complement Med Ther. 2022;22(1):1–11.CrossRef

68.

Arya SS, Rookes JE, Cahill DM, Lenka SK. Vanillin: a review on the therapeutic prospects of a popular flavouring molecule. Adv Tradit Med. 2021;21(3):1–17. https://doi.org/10.1007/s13596-020-00531-w.CrossRef

69.

Calderón-Montaño JM, Burgos-Morón E, Pérez-Guerrero C, López-Lázaro M. A review on the dietary flavonoid kaempferol. Mini Rev Med Chem. 2011;11(4):298–344. https://doi.org/10.2174/138955711795305335.CrossRefPubMed

70.

Verotta L, Dell’Agli M, Giolito A, Guerrini M, Cabalion P, Bosisio E. In vitro antiplasmodial activity of extracts of Tristaniopsis species and identification of the active constituents: Ellagic acid and 3,4,5-Trimethoxyphenyl-(6‘-O-galloyl)-O-β-d-glucopyranoside. J Nat Prod. 2001;64(5):603–7. https://doi.org/10.1021/np000306j.CrossRefPubMed

71.

Abiodun OO, Rodríguez-Nogales A, Algieri F, Gomez-Caravaca AM, Segura-Carretero A, Utrilla MP, Rodriguez-Cabezas ME, Galvez J. Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae): In vitro and in vivo evidences. J Ethnopharmacol. 2016;192:309–19. https://doi.org/10.1016/j.jep.2016.07.056.CrossRefPubMed

72.

Dunst J, Kamena F, Matuschewski K. Cytokines and chemokines in cerebral malaria pathogenesis. Front Cell Infect Microbiol. 2017;7:324. https://doi.org/10.3389/fcimb.2017.00324.CrossRefPubMedPubMedCentral

73.

Kossodo S, Monso C, Juillard P, Velu T, Goldman M, Grau GE. Interleukin-10 modulates susceptibility in experimental cerebral malaria. Immunology. 1997;91(4):536–40. https://doi.org/10.1046/j.1365-2567.1997.00290.x.CrossRefPubMedPubMedCentral

74.

Hugosson E, Montgomery SM, Premji Z, Troye-Blomberg M, Björkman A. Higher IL-10 levels are associated with less effective clearance of Plasmodium falciparum parasites. Parasite Immunol. 2004;26(3):111–7. https://doi.org/10.1111/j.0141-9838.2004.00678.x.CrossRefPubMed

75.

Yu H, Huang X, Ma Y, Gao M, Wang O, Gao T, Shen Y, Liu X. Interleukin-8 regulates endothelial permeability by down-regulation of tight junction but not dependent on integrins induced focal adhesions. Int J Biol Sci. 2013;9(9):966.CrossRefPubMedPubMedCentral

76.

Wilson NO, Jain V, Roberts CE, Lucchi N, Joel PK, Singh MP, Nagpal AC, Dash AP, Udhayakumar V, Singh N. CXCL4 and CXCL10 predict risk of fatal cerebral malaria. Dis Markers. 2011;30(1):39–49.CrossRefPubMedPubMedCentral

77.

Lyke KE, Burges R, Cissoko Y, Sangare L, Dao M, Diarra I, Kone A, Harley R, Plowe CV, Doumbo OK, et al. Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls. Infect Immun. 2004;72(10):5630–7. https://doi.org/10.1128/iai.72.10.5630-5637.2004.CrossRefPubMedPubMedCentral

78.

Wunderlich CM, Delić D, Behnke K, Meryk A, Ströhle P, Chaurasia B, Al-Quraishy S, Wunderlich F, Brüning JC, Wunderlich FT. Cutting edge: Inhibition of IL-6 trans-signaling protects from malaria-induced lethality in mice. J Immunol. 2012;188(9):4141–4.CrossRefPubMed

79.

Nsiah K, Bahaah B, Oppong Afranie B, Koffie S, Akowuah E, Donkor S. Oxidative stress and hemoglobin level of complicated and uncomplicated malaria cases among children: a cross-sectional study in kumasi metropolis, ghana. J Trop Med. 2019;2019:8479076. https://doi.org/10.1155/2019/8479076.CrossRefPubMedPubMedCentral

80.

Rendeiro C, Rhodes JS, Spencer JPE. The mechanisms of action of flavonoids in the brain: Direct versus indirect effects. Neurochem Int. 2015;89:126–39. https://doi.org/10.1016/j.neuint.2015.08.002.CrossRefPubMed

81.

Boggild AK, Krudsood S, Patel SN, Serghides L, Tangpukdee N, Katz K, Wilairatana P, Liles WC, Looareesuwan S, Kain KC. Use of peroxisome proliferator-activated receptor γ agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2009;49(6):841–9.CrossRefPubMed

82.

Medana IM, Turner GD. Human cerebral malaria and the blood-brain barrier. Int J Parasitol. 2006;36(5):555–68. https://doi.org/10.1016/j.ijpara.2006.02.004.CrossRefPubMed

83.

Lima MN, Oliveira HA, Fagundes PM, Estato V, Silva AYO, Freitas RJRX, Passos BABR, Oliveira KS, Batista CN, Vallochi AL, et al. Mesenchymal stromal cells protect against vascular damage and depression-like behavior in mice surviving cerebral malaria. Stem Cell Res Ther. 2020;11(1):367. https://doi.org/10.1186/s13287-020-01874-6.CrossRefPubMedPubMedCentral

84.

de Miranda AS, Brant F, Vieira LB, Rocha NP, Vieira ÉLM, Rezende GHS, de Oliveira Pimentel PM, Moraes MF, Ribeiro FM, Ransohoff RM. A neuroprotective effect of the glutamate receptor antagonist MK801 on long-term cognitive and behavioral outcomes secondary to experimental cerebral malaria. Mol Neurobiol. 2017;54(9):7063–82.CrossRefPubMed

Title: Efficacy of artesunate combined with Atractylodes lancea or Prabchompoothaweep remedy extracts as adjunctive therapy for the treatment of cerebral malaria
Authors: Walaiporn Plirat
Prapaporn Chaniad
Arisara Phuwajaroanpong
Atthaphon Konyanee
Parnpen Viriyavejakul
Abdi Wira Septama
Chuchard Punsawad
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Malaria
Antimalaria
Plasmodia
Published in: BMC Complementary Medicine and Therapies / Issue 1/2023
Electronic ISSN: 2662-7671
DOI: https://doi.org/10.1186/s12906-023-04150-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Efficacy of artesunate combined with Atractylodes lancea or Prabchompoothaweep remedy extracts as adjunctive therapy for the treatment of cerebral malaria

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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