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European Radiology
Published in: European Radiology 11/2019

01-11-2019 | Magnetic Resonance Imaging | Ultrasound

Autosomal dominant polycystic kidney disease: new role for ultrasound

Authors: Hakan İmamoğlu, Gökmen Zararsız, Serap Doğan, İsmail Koçyiğit, Eray Eroğlu, Ahmet Öztürk, Nuri Erdoğan

Published in: European Radiology | Issue 11/2019

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Abstract

Objectives

To evaluate the accuracy of US in calculating renal volumes and renal resistive index (RRI) that was obtained using a new method in patients with autosomal dominant polycystic kidney disease (ADPKD).

Methods

In this prospective study, US and MRI were performed in 57 patients with ADPKD (31 female and 26 male; age range, 19–79 years) between August 2017 and May 2018. The volumes determined using US and MRI were compared. The ellipsoid formula was re-evaluated using different multipliers. RRI was obtained 1.5–2 cm distal to the outlet of main renal arteries. The relationship between mean RRI, renal function tests, and kidney volumes and difference between mean RRI of ADPKD patients with and without renal failure were investigated using a two-sided independent samples t test and Pearson correlation test. Interobserver agreements for volume assessments and RRI measurements were determined.

Results

By changing the ellipsoid formula, a very good agreement was found (ICC 0.970 for the right kidney and ICC 0.973 for the left kidney). The mean RRI in the right renal artery was 0.61 ± 0.07 and in the left renal artery 0.63 ± 0.06. The mean RRI of ADPKD patients with renal failure was significantly higher than that of patients without renal failure (p = 0.005). There was a significant correlation between mean RRI and renal function tests.

Conclusion

The accuracy of the US in calculating renal volumes increases by adapting the ellipsoid formula. RRI may be used for the management of ADPKD independently of volumes.

Key Points

•The accuracy of ultrasonography for renal volume measurement increases by changing the classical ellipsoid formula.
•Renal resistive index measured by color Doppler ultrasonography is helpful for the management of autosomal dominant polycystic kidney disease.
•The role of Doppler US in autosomal dominant polycystic kidney disease should increase as a result of our findings.
Literature
1.
Torres VE, Harris PC, Pirson Y (2007) Autosomal dominant polycystic kidney disease. Lancet 369:1287–1301CrossRef
2.
Sung CK, Kim SH, Ahn C (2008) Grayscale and Doppler ultrasonographic findings reflecting disease severity in autosomal dominant polycystic kidney disease. J Med Ultrasound 16:65–73CrossRef
3.
Pei Y, Obaji J, Dupuis A et al (2009) Unified criteria for ultrasonographic diagnosis of ADPKD. J Am Soc Nephrol 20:205–212CrossRef
4.
Nicolau C, Torra R, Badena C et al (1999) Autosomal dominant polycystic kidney disease types 1 and 2: assessment of US sensitivity for diagnosis. Radiology 213:273–276CrossRef
5.
Demetriou K, Tziakouri C, Anninou K et al (2000) Autosomal dominant polycystic kidney disease-type 2. Ultrasound, genetic and clinical correlations. Nephrol Dial Transplant 15:205–211CrossRef
6.
Grantham JJ, Torres VE, Chapman AB et al (2006) Volume progression in polycystic kidney disease. N Engl J Med 354:2122–2130CrossRef
7.
8.
9.
Platt JF, Ellis JH, Rubin JM, DiPietro MA, Sedman AB (1990) Intrarenal arterial Doppler sonography in patients with non-obstructive renal disease: correlation of resistive index with biopsy finding. AJR Am J Roentgenol 154:1223–1227CrossRef
10.
Patriquin HB, O’Regan S, Robitaille P, Paltiel H (1989) Hemolytic–uremic syndrome: intrarenal arterial Doppler patterns as a useful guide to therapy. Radiology 172:625–628CrossRef
11.
Kim SH, Kim WH, Choi BI, Kim CW (1992) Duplex Doppler US in patients with medical renal disease: resistive index vs serum creatinine level. Clin Radiol 45:85–87CrossRef
12.
Chapman AB, Johnson A, Gabow PA et al (1990) The renin angiotensin-aldosterone system and autosomal dominant polycystic kidney disease. N Engl J Med 323:1091–1096CrossRef
13.
Sawicki M, Walecka A, Rozanski J, Safranow K, Ciechanowski K (2009) Doppler sonography measurements of renal vascular resistance in autosomal-dominant polycystic kidney disease. Med Sci Monit 15:101–104
14.
Bae KT, Tao C, Wang J et al (2013) Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP). Novel approach to estimate kidney and cyst volumes using mid-slice magnetic resonance images in polycystic kidney disease. Am J Nephrol 38:333–341CrossRef
15.
Bakker J, Olree M, Kaatee R, De Lange EE, Beek FJA (1997) In vitro measurement of kidney size: comparison of ultrasonography and MRI. Ultrasound Med Biol 24:683–688CrossRef
16.
Bakker J, Olree M, Kaatee R et al (1999) Renal volume measurements: accuracy and repeatability of US compared with that of MR imaging. Radiology 211:623–628CrossRef
17.
O’Neill WC, Robbin ML, Bae KT et al (2005) Sonographic assessment of the severity and progression of autosomal dominant polycystic kidney disease: the Consortium of Renal Imaging Studies in Polycystic Kidney Disease (CRISP). Am J Kidney Dis 46:1058–1064CrossRef
18.
Hammoud S, Tissier AM, Elie C et al (2015) Ultrasonographic renal volume measurements in early autosomal dominant polycystic disease: comparison with CT-scan renal volume calculations. Diagn Interv Imaging 96:65–71CrossRef
19.
Edell SL, Kurtz AB, Rifkin MD (1990) Normal renal ultrasound measurements. In: Goldberg BB, Kurtz AB (eds) Atlas of ultrasound measurements. Mosby- Year Book Chigago
20.
Kim HC, Yang DM, Lee SH, Cho YD (2008) Usefulness of renal volume measurements obtained by a 3-dimensional sonographic transducer with matrix electronic arrays. J Ultrasound Med 27:1673–1681CrossRef
21.
Kim HC, Yang DM, Jin W, Lee SH (2010) Relation between total renal volume and renal function: usefulness of 3D sonographic measurements with a matrix array transducer. AJR Am J Roentgenol 194:W186–W192CrossRef
22.
Riccabona M, Fritz GA, Schöllnast H, Schwarz T, Deutschmann MJ, Mache CJ (2005) Hydronephrotic kidney: pediatric three-dimensional US for relative renal size assessment—initial experience. Radiology 236:276–283CrossRef
23.
Brancaforte A, Serantoni S, Silva Barbosa F, Di Leo G, Sardanelli F, Cornalba GP (2011) Renal volume assessment with 3D ultrasound. Radiol Med 116:1095–1104CrossRef
24.
Breysem L, De Rechter S, De Keyzer F et al (2018) 3DUS as an alternative to MRI for measuring renal volume in children with autosomal dominant polycystic kidney disease. Pediatr Nephrol 33:827–835CrossRef
25.
Kelcz F, Pozniak MA, Pirsch JD, Oberly TD (1990) Pyramidal appearance and resistive index: insensitive and nonspecific sonographic indicators of renal transplant rejection. AJR Am J Roentgenol 155:531–535CrossRef
26.
Chen P, Maklad N, Redwine M (1998) Color and power Doppler imaging of the kidneys. World J Urol 16:41–45CrossRef
27.
Afsar B, Elsurer R (2017) Increased renal resistive index in type 2 diabetes: clinical relevance, mechanisms and future directions. Diabetes Metab Syndr 11:291–296CrossRef
28.
Hanamura K, Tojo A, Kinugasa S, Asaba K, Fujita T (2012) The resistive index is a marker of renal function, pathology, prognosis, and responsiveness to steroid therapy in chronic kidney disease patients. Int J Nephrol 2012:139565CrossRef
29.
Parolini C, Noce A, Staffolani E, Giarrizzo GF, Costanzi S, Splendiani G (2009) Renal resistive index and long-term outcome in chronic nephropathies. Radiology 252:888–896CrossRef
30.
Brkljacic B, Sabljar-Matovinovic M, Putarek K, Soldo D, Morovic-Vergles J, Hauser M (1997) Renal vascular resistance in autosomal dominant polycystic kidney disease. Evaluation with color Doppler ultrasound. Acta Radiol 38:840–846PubMed
31.
Kondo A, Akakura K, Ito H (2001) Assessment of renal function with color Doppler ultrasound in autosomal dominant polycystic kidney disease. Int J Urol 8:95–98CrossRef
32.
Parfrey PS, Bear JC, Morgan J et al (1990) The diagnosis and prognosis of autosomal dominant polycystic kidney disease. N Engl J Med 323:1086–1090CrossRef
33.
Gabow PA, Schrier RW (1989) Pathophysiology of adult polycystic kidney disease. Adv Nephrol 18:19–32
34.
King BF, Torres VE, Brummer ME et al (2003) Magnetic resonance measurements of renal blood flow as a marker of disease severity in autosomal dominant polycystic kidney disease. Kidney Int 64:2214–2221CrossRef
Metadata
Title
Autosomal dominant polycystic kidney disease: new role for ultrasound
Authors
Hakan İmamoğlu
Gökmen Zararsız
Serap Doğan
İsmail Koçyiğit
Eray Eroğlu
Ahmet Öztürk
Nuri Erdoğan
Publication date
01-11-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 11/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-019-06238-0

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