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Journal of Cardiovascular Magnetic Resonance

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01-12-2020 | Magnetic Resonance Imaging | Research

Three-dimensional assessment of coronary high-intensity plaques with T1-weighted cardiovascular magnetic resonance imaging to predict periprocedural myocardial injury after elective percutaneous coronary intervention

Authors: Hayato Hosoda, Yasuhide Asaumi, Teruo Noguchi, Yoshiaki Morita, Yu Kataoka, Fumiyuki Otsuka, Kazuhiro Nakao, Masashi Fujino, Toshiyuki Nagai, Michikazu Nakai, Kunihiro Nishimura, Atsushi Kono, Yoshiaki Komori, Tomoya Hoshi, Akira Sato, Tomohiro Kawasaki, Chisato Izumi, Kengo Kusano, Tetsuya Fukuda, Satoshi Yasuda

Published in: Journal of Cardiovascular Magnetic Resonance | Issue 1/2020

Abstract

Background

Periprocedural myocardial injury (pMI) is a common complication of elective percutaneous coronary intervention (PCI) that reduces some of the beneficial effects of coronary revascularization and impacts the risk of cardiovascular events. We developed a 3-dimensional volumetric cardiovascular magnetic resonance (CMR) method to evaluate coronary high intensity plaques and investigated their association with pMI after elective PCI.

Methods

Between October 2012 and October 2016, 141 patients with stable coronary artery disease underwent T1-weighted CMR imaging before PCI. A conventional 2-dimensional CMR plaque-to-myocardial signal intensity ratio (2D-PMR) and the newly developed 3-dimensional integral of PMR (3Di-PMR) were measured. 3Di-PMR was determined as the sum of PMRs above a threshold of > 1.0 for voxels in a target plaque. pMI was defined as high-sensitivity cardiac troponin T > 0.07 ng/mL.

Results

pMI following PCI was observed in 46 patients (33%). 3Di-PMR was significantly higher in patients with pMI than those without pMI. The optimal 3Di-PMR cutoff value for predicting pMI was 51 PMR*mm³ and the area under the receiver operating characteristic curve (0.753) was significantly greater than that for 2D-PMR (0.683, P = 0.015). 3Di-PMR was positively correlated with lipid volume (r = 0.449, P < 0.001) based on intravascular ultrasound.

Stepwise multivariable analysis showed that 3Di-PMR ≥ 51 PMR*mm³ and the presence of a side branch at the PCI target lesion site were significant predictors of pMI (odds ratio [OR], 11.9; 95% confidence interval [CI], 4.6–30.4, P < 0.001; and OR, 4.14; 95% CI, 1.6–11.1, P = 0.005, respectively).

Conclusions

3Di-PMR coronary assessment facilitates risk stratification for pMI after elective PCI.

Trial registration

retrospectively registered.

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Title: Three-dimensional assessment of coronary high-intensity plaques with T1-weighted cardiovascular magnetic resonance imaging to predict periprocedural myocardial injury after elective percutaneous coronary intervention
Authors: Hayato Hosoda
Yasuhide Asaumi
Teruo Noguchi
Yoshiaki Morita
Yu Kataoka
Fumiyuki Otsuka
Kazuhiro Nakao
Masashi Fujino
Toshiyuki Nagai
Michikazu Nakai
Kunihiro Nishimura
Atsushi Kono
Yoshiaki Komori
Tomoya Hoshi
Akira Sato
Tomohiro Kawasaki
Chisato Izumi
Kengo Kusano
Tetsuya Fukuda
Satoshi Yasuda
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Intravascular Ultrasound
CT Angiography
Arterial Occlusive Disease
Published in: Journal of Cardiovascular Magnetic Resonance / Issue 1/2020
Electronic ISSN: 1532-429X
DOI: https://doi.org/10.1186/s12968-019-0588-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Three-dimensional assessment of coronary high-intensity plaques with T1-weighted cardiovascular magnetic resonance imaging to predict periprocedural myocardial injury after elective percutaneous coronary intervention

Abstract

Background

Methods

Results

Conclusions

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

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