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Open Access 01-12-2022 | Magnetic Resonance Imaging | Study protocol

Study protocol of Branch Atheromatous Disease-related stroke (BAD-study): a multicenter prospective cohort study

Authors: Shengde Li, Jun Ni, Xiaoyuan Fan, Ming Yao, Feng Feng, Dongxue Li, Jianxun Qu, Yicheng Zhu, Lixin Zhou, Bin Peng

Published in: BMC Neurology | Issue 1/2022

Abstract

Background

As a meaningful subtype of ischemic stroke in Asians, Branch atheromatous disease (BAD)-related stroke is associated with high early neurological deterioration (END) and disability, but is understudied and without recommended therapy. The mechanism of END still remains unclear. Branch atheromatous disease-related stroke study (BAD-study) therefore aims to investigate demographic, clinical and radiological features, and prognosis of BAD-related stroke in Chinese patients.

Methods/design

BAD-study is a nationwide, multicenter, consecutive, prospective, observational cohort study enrolling patients aged 18–80 years with BAD-related stroke within 72 h after symptom onset. Initial clinical data, laboratory tests, and imaging data are collected via structured case report form, and follow-ups will be performed at 7 days, 30 days, 90 days, 6 months and 12 months after enrollment. The primary outcome is the score on modified Rankin Scale at 90-day follow-up with single-blinded assessment. Secondary outcomes include END within 7 days, and National institute of health stroke scale score, Barthel index, cerebrovascular events, major bleeding complications, and all-cause mortality during 90-day follow-up. Characteristics of penetrating and parent artery will be assessed by high-resolution magnetic resonance imaging combined with other imaging techniques.

Discussion

BAD-study can provide demographic, clinical, radiological, and prognostic characteristics of BAD-related stroke, and thereby potentially figure out the vascular mechanism of early neurological deterioration and optimize therapy strategy with the aid of advanced imaging technique. Baseline data and evidence will also be generated for randomized controlled trials on BAD-related stroke in the future.

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Title: Study protocol of Branch Atheromatous Disease-related stroke (BAD-study): a multicenter prospective cohort study
Authors: Shengde Li
Jun Ni
Xiaoyuan Fan
Ming Yao
Feng Feng
Dongxue Li
Jianxun Qu
Yicheng Zhu
Lixin Zhou
Bin Peng
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Stroke
Published in: BMC Neurology / Issue 1/2022
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-022-02976-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Study protocol of Branch Atheromatous Disease-related stroke (BAD-study): a multicenter prospective cohort study

Abstract

Background

Methods/design

Discussion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods/design

Discussion

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