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Skeletal Radiology
Published in: Skeletal Radiology 11/2020

01-11-2020 | Magnetic Resonance Imaging | Scientific Article

Soft tissue sarcoma: can dynamic contrast-enhanced (DCE) MRI be used to predict the histological grade?

Authors: Xiangwen Li, Qimeng Wang, Yanping Dou, Yu Zhang, Juan Tao, Lin Yang, Shaowu Wang

Published in: Skeletal Radiology | Issue 11/2020

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Abstract

Objective

To determine if dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters reflect histological grade of soft tissue sarcoma (STS)

Materials and methods

The medical records of 50 patients diagnosed with pathologically confirmed STS were retrospectively reviewed. Each STS was assessed with conventional contrast-enhanced MRI and DCE-MRI using a 3.0-T MRI system. The conventional MRI characteristics of low-grade (grade 1) and high-grade (grade 2 and grade 3) tumors were analyzed. Semi-quantitative parameters, including iAUC and TTP, and quantitative parameters, including Ktrans, Kep, and Ve, were derived from DCE-MRI. The diagnostic performances and optimal thresholds of various combinations of DCE-MRI parameters for predicting histological grades of STS were investigated using receiver operator characteristic (ROC) curves.

Results

On conventional MRI, high-grade STSs were significantly larger (≥ 5 cm) and more likely to show a heterogeneous signal intensity on T2WI (> 75%), peritumoral hyperintensity on T2WI, or tumor necrosis (> 50%) compared with low-grade STS. On DCE-MRI, iAUC, TTP, Ktrans, and Kep were significant predictors of STS histological grade. Ktrans had a high diagnostic value for differentiating between high-grade and low-grade STSs. The combination of iAUC, TTP, and Ktrans yielded a higher AUC value (0.841) than the other models.

Conclusion

High-grade STSs were usually larger than low-grade STSs, had unclear boundaries, a heterogeneous signal intensity on T2-weighted image (T2WI), and extensive necrosis. On DCE-MRI, iAUC, TTP, Ktrans, and Kep could differentiate between high-grade and low-grade STSs. The combination of iAUC, TTP, and Ktrans had a high diagnostic performance for differentiating between STS histological grades.
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Metadata
Title
Soft tissue sarcoma: can dynamic contrast-enhanced (DCE) MRI be used to predict the histological grade?
Authors
Xiangwen Li
Qimeng Wang
Yanping Dou
Yu Zhang
Juan Tao
Lin Yang
Shaowu Wang
Publication date
01-11-2020
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 11/2020
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-020-03491-z

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