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European Radiology
Published in: European Radiology 10/2019

01-10-2019 | Magnetic Resonance Imaging | Chest

Predicting pathological subtypes and stages of thymic epithelial tumors using DWI: value of combining ADC and texture parameters

Authors: Bo Li, Yong-kang Xin, Gang Xiao, Gang-feng Li, Shi-jun Duan, Yu Han, Xiu-long Feng, Wei-qiang Yan, Wei-cheng Rong, Shu-mei Wang, Yu-chuan Hu, Guang-bin Cui

Published in: European Radiology | Issue 10/2019

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Abstract

Objectives

To explore the value of combining apparent diffusion coefficients (ADC) and texture parameters from diffusion-weighted imaging (DWI) in predicting the pathological subtypes and stages of thymic epithelial tumors (TETs).

Methods

Fifty-seven patients with TETs confirmed by pathological analysis were retrospectively enrolled. ADC values and optimal texture feature parameters were compared for differences among low-risk thymoma (LRT), high-risk thymoma (HRT), and thymic carcinoma (TC) by one-way ANOVA, and between early and advanced stages of TETs were tested using the independent samples t test. Receiver operating characteristic (ROC) curve analysis was performed to determine the differentiating efficacy.

Results

The ADC values in LRT and HRT were significantly higher than the values in TC (p = 0.004 and 0.001, respectively), also in early stage, values were significantly higher than ones in advanced stage of TETs (p < 0.001). Among all texture parameters analyzed in order to differentiate LRT from HRT and TC, the V312 achieved higher diagnostic efficacy with an AUC of 0.875, and combination of ADC and V312 achieved the highest diagnostic efficacy with an AUC of 0.933, for differentiating the LRT from HRT and TC. Furthermore, combination of ADC and V1030 achieved a relatively high differentiating ability with an AUC of 0.772, for differentiating early from advanced stages of TETs.

Conclusions

Combination of ADC and DWI texture parameters improved the differentiating ability of TET grades, which could potentially be useful in clinical practice regarding the TET evaluation before treatment.

Key Points

• DWI texture analysis is useful in differentiating TET subtypes and stages.
• Combination of ADC and DWI texture parameters may improve the differentiating ability of TET grades.
• DWI texture analysis could potentially be useful in clinical practice regarding the TET evaluation before treatment.
Appendix
Available only for authorised users
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Metadata
Title
Predicting pathological subtypes and stages of thymic epithelial tumors using DWI: value of combining ADC and texture parameters
Authors
Bo Li
Yong-kang Xin
Gang Xiao
Gang-feng Li
Shi-jun Duan
Yu Han
Xiu-long Feng
Wei-qiang Yan
Wei-cheng Rong
Shu-mei Wang
Yu-chuan Hu
Guang-bin Cui
Publication date
01-10-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 10/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-019-06080-4

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