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Published in: Insights into Imaging 1/2023

Open Access 01-12-2023 | Magnetic Resonance Imaging | Educational Review

MRI anatomy of the rectum: key concepts important for rectal cancer staging and treatment planning

Authors: Nino Bogveradze, Petur Snaebjornsson, Brechtje A. Grotenhuis, Baukelien van Triest, Max J. Lahaye, Monique Maas, Geerard L. Beets, Regina G. H. Beets-Tan, Doenja M. J. Lambregts

Published in: Insights into Imaging | Issue 1/2023

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Abstract

A good understanding of the MRI anatomy of the rectum and its surroundings is pivotal to ensure high-quality diagnostic evaluation and reporting of rectal cancer. With this pictorial review, we aim to provide an image-based overview of key anatomical concepts essential for treatment planning, response evaluation and post-operative assessment. These concepts include the cross-sectional anatomy of the rectal wall in relation to T-staging; differences in staging and treatment between anal and rectal cancer; landmarks used to define the upper and lower boundaries of the rectum; the anatomy of the pelvic floor and anal canal, the mesorectal fascia, peritoneum and peritoneal reflection; and guides to help discern different pelvic lymph node stations on MRI to properly stage regional and non-regional rectal lymph node metastases. Finally, this review will highlight key aspects of post-treatment anatomy, including the assessment of radiation-induced changes and the evaluation of the post-operative pelvis after different surgical resection and reconstruction techniques.
Literature
1.
go back to reference MERCURY Study Group (2007) Extramural depth of tumour invasion at thin-section MR in patients with rectal cancer: results of the MERCURY study. Radiology 243(1):132–139CrossRef MERCURY Study Group (2007) Extramural depth of tumour invasion at thin-section MR in patients with rectal cancer: results of the MERCURY study. Radiology 243(1):132–139CrossRef
2.
go back to reference Beets-Tan RGH, Lambregts DMJ, Maas M et al (2018) Magnetic resonance imaging for clinical management of rectal cancer: updated recommendations from the 2016 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus meeting. Eur Radiol 28(4):1465–1575CrossRef Beets-Tan RGH, Lambregts DMJ, Maas M et al (2018) Magnetic resonance imaging for clinical management of rectal cancer: updated recommendations from the 2016 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus meeting. Eur Radiol 28(4):1465–1575CrossRef
3.
go back to reference Brown G, Radcliffe AG, Newcombe RG, Dallimore NS, Bourne MW (2003) Williams GT preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging. Br J Surg 90(3):355–364CrossRef Brown G, Radcliffe AG, Newcombe RG, Dallimore NS, Bourne MW (2003) Williams GT preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging. Br J Surg 90(3):355–364CrossRef
4.
go back to reference Glynne-Jones R, Wyrwicz L, Tiret E et al (2017) Rectal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 28:22–40CrossRef Glynne-Jones R, Wyrwicz L, Tiret E et al (2017) Rectal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 28:22–40CrossRef
5.
go back to reference Valentini V, Aristei C, Glimelius B et al (2009) Multidisciplinary rectal cancer management: 2nd European rectal cancer consensus conference (EURECA-CC2). Radiother Oncol 92(2):148–163CrossRef Valentini V, Aristei C, Glimelius B et al (2009) Multidisciplinary rectal cancer management: 2nd European rectal cancer consensus conference (EURECA-CC2). Radiother Oncol 92(2):148–163CrossRef
6.
go back to reference Lahaye MJ, Engelen SM, Nelemans PJ et al (2005) Imaging for predicting the risk factors–the circumferential resection margin and nodal disease-of local recurrence in rectal cancer: a meta-analysis. Semin Ultrasound CT MR 26(4):259–268CrossRef Lahaye MJ, Engelen SM, Nelemans PJ et al (2005) Imaging for predicting the risk factors–the circumferential resection margin and nodal disease-of local recurrence in rectal cancer: a meta-analysis. Semin Ultrasound CT MR 26(4):259–268CrossRef
7.
go back to reference Bipat S, Glas AS, Slors FJ, Zwinderman AH, Bossuyt PM, Stoker J (2004) Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging—a meta-analysis. Radiology 232(3):773–783CrossRef Bipat S, Glas AS, Slors FJ, Zwinderman AH, Bossuyt PM, Stoker J (2004) Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging—a meta-analysis. Radiology 232(3):773–783CrossRef
8.
go back to reference Lambregts DM, Vandecaveye V, Barbaro B, et al. (2011) Diffusion-weighted MRI for selection of complete responders after chemoradiation for locally advanced rectal cancer: a multicenter study. Ann Surg Oncol 18(8):2224–2231CrossRef Lambregts DM, Vandecaveye V, Barbaro B, et al. (2011) Diffusion-weighted MRI for selection of complete responders after chemoradiation for locally advanced rectal cancer: a multicenter study. Ann Surg Oncol 18(8):2224–2231CrossRef
9.
go back to reference Maas M, Beets-Tan RG, Lambregts DM et al (2011) Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer. J Clin Oncol 29(35):4633–4640CrossRef Maas M, Beets-Tan RG, Lambregts DM et al (2011) Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer. J Clin Oncol 29(35):4633–4640CrossRef
10.
go back to reference Brown PJ, Hyland R, Quyn AJ, et al. (2019) Current concepts in imaging for local staging of advanced rectal cancer. Clin Radiol 74(8):623–636CrossRef Brown PJ, Hyland R, Quyn AJ, et al. (2019) Current concepts in imaging for local staging of advanced rectal cancer. Clin Radiol 74(8):623–636CrossRef
11.
go back to reference Gollub MJ, Das JP, Bates DDB, et al. (2021) Rectal cancer with complete endoscopic response after neoadjuvant therapy: What is the meaning of a positive MRI? Eur Radiol 31(7):4731–4738CrossRef Gollub MJ, Das JP, Bates DDB, et al. (2021) Rectal cancer with complete endoscopic response after neoadjuvant therapy: What is the meaning of a positive MRI? Eur Radiol 31(7):4731–4738CrossRef
12.
go back to reference Horvat N, Carlos Tavares Rocha C, Clemente Oliveira B, Petkovska I, Gollub MJ (2019) MRI of rectal cancer: tumour staging, imaging techniques, and management. Radiographics 39(2):367–387CrossRef Horvat N, Carlos Tavares Rocha C, Clemente Oliveira B, Petkovska I, Gollub MJ (2019) MRI of rectal cancer: tumour staging, imaging techniques, and management. Radiographics 39(2):367–387CrossRef
13.
go back to reference Hoeffel C, Arrivé L, Mourra N, Azizi L, Lewin M, Tubiana JM (2006) Anatomic and pathologic findings at external phased-array pelvic MR imaging after surgery for anorectal disease. Radiographics 26(5):1391–1407CrossRef Hoeffel C, Arrivé L, Mourra N, Azizi L, Lewin M, Tubiana JM (2006) Anatomic and pathologic findings at external phased-array pelvic MR imaging after surgery for anorectal disease. Radiographics 26(5):1391–1407CrossRef
15.
go back to reference Jessup MJ, Goldberg RM, Asare EA et al (2017) CP Colon and Rectum. In: Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, Washington MK et al (eds) AJCC cancer staging manual, 8th edn. Springer, Berlin, pp 251–273CrossRef Jessup MJ, Goldberg RM, Asare EA et al (2017) CP Colon and Rectum. In: Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, Washington MK et al (eds) AJCC cancer staging manual, 8th edn. Springer, Berlin, pp 251–273CrossRef
17.
go back to reference Wittekind C, Brierly JD, Lee AWM et al (2019) CP. Explanatory notes specific anatomical sites. In: Wittekind C, Brierly JD, Lee AWM et al (eds) TNM supplement A commentary uniform use. Wiley-Liss, New York, pp 54–85CrossRef Wittekind C, Brierly JD, Lee AWM et al (2019) CP. Explanatory notes specific anatomical sites. In: Wittekind C, Brierly JD, Lee AWM et al (eds) TNM supplement A commentary uniform use. Wiley-Liss, New York, pp 54–85CrossRef
18.
go back to reference D’Souza N, Balyasnikova S, Tudyka V et al (2018) Variation in landmarks for the rectum: an MRI study. Colorectal Dis 20(10):O304–O309CrossRef D’Souza N, Balyasnikova S, Tudyka V et al (2018) Variation in landmarks for the rectum: an MRI study. Colorectal Dis 20(10):O304–O309CrossRef
19.
go back to reference Dsouza N, de Neree Tot Babberich MPM, d’Hoore A et al (2019) Definition of the rectum: an international, expert-based Delphi consensus. Ann Surg 270(6):955–959CrossRef Dsouza N, de Neree Tot Babberich MPM, d’Hoore A et al (2019) Definition of the rectum: an international, expert-based Delphi consensus. Ann Surg 270(6):955–959CrossRef
22.
go back to reference Jorge JMN, Habr-Gama A (2014) Anatomy and embryology of the colon, rectum and anus. In: Beck DE, Nasseri Y, Hull TL et al (eds) The ASCRS manual of colon and rectal surgery, 2nd edn. Springer, Berlin, pp 1–27 Jorge JMN, Habr-Gama A (2014) Anatomy and embryology of the colon, rectum and anus. In: Beck DE, Nasseri Y, Hull TL et al (eds) The ASCRS manual of colon and rectal surgery, 2nd edn. Springer, Berlin, pp 1–27
27.
go back to reference van Rees JM, Elferink MAG, Tanis PJ et al (2021) The incidence, treatment and survival of patients with rare types of rectal malignancies in the Netherlands: a population-based study between 1989 and 2018. Eur J Cancer 152:183–192CrossRef van Rees JM, Elferink MAG, Tanis PJ et al (2021) The incidence, treatment and survival of patients with rare types of rectal malignancies in the Netherlands: a population-based study between 1989 and 2018. Eur J Cancer 152:183–192CrossRef
28.
go back to reference Lukovic J, Kim JJ, Krzyzanowska M et al (2020) Anal adenocarcinoma: a rare malignancy in need of multidisciplinary management. JCO Oncol Pract 16(10):635–640CrossRef Lukovic J, Kim JJ, Krzyzanowska M et al (2020) Anal adenocarcinoma: a rare malignancy in need of multidisciplinary management. JCO Oncol Pract 16(10):635–640CrossRef
29.
go back to reference Glimelius B, Beets-Tan R, Blomqvist L et al (2011) Mesorectal fascia instead of circumferential resection margin in preoperative staging of rectal cancer. J Clin Oncol 29(16):2142–2143CrossRef Glimelius B, Beets-Tan R, Blomqvist L et al (2011) Mesorectal fascia instead of circumferential resection margin in preoperative staging of rectal cancer. J Clin Oncol 29(16):2142–2143CrossRef
30.
go back to reference Gollub MJ, Maas M, Weiser M et al (2013) Recognition of the anterior peritoneal reflection at rectal MRI. AJR Am J Roentgenol 200:97–101CrossRef Gollub MJ, Maas M, Weiser M et al (2013) Recognition of the anterior peritoneal reflection at rectal MRI. AJR Am J Roentgenol 200:97–101CrossRef
31.
go back to reference Sakorafas GH, Zouros E, Peros G (2006) Applied vascular anatomy of the colon and rectum: clinical implications for the surgical oncologist. Surg Oncol 15(4):243–255CrossRef Sakorafas GH, Zouros E, Peros G (2006) Applied vascular anatomy of the colon and rectum: clinical implications for the surgical oncologist. Surg Oncol 15(4):243–255CrossRef
32.
go back to reference Smith NJ, Shihab O, Arnaout A, Swift RI, Brown G (2008) MRI for detection of extramural vascular invasion in rectal cancer. AJR Am J Roentgenol 191(5):1517–1522CrossRef Smith NJ, Shihab O, Arnaout A, Swift RI, Brown G (2008) MRI for detection of extramural vascular invasion in rectal cancer. AJR Am J Roentgenol 191(5):1517–1522CrossRef
33.
go back to reference Tan JJ, Carten RV, Babiker A, Abulafi M, Lord AC, Brown G (2021) Prognostic importance of MRI-detected extramural venous invasion in rectal cancer: a literature review and systematic meta-analysis. Int J Radiat Oncol Biol Phys 111(2):385–394CrossRef Tan JJ, Carten RV, Babiker A, Abulafi M, Lord AC, Brown G (2021) Prognostic importance of MRI-detected extramural venous invasion in rectal cancer: a literature review and systematic meta-analysis. Int J Radiat Oncol Biol Phys 111(2):385–394CrossRef
34.
go back to reference Dworak O (1991) Morphology of lymph nodes in the resected rectum of patients with rectal carcinoma. Pathol Res Pract 187(8):1020–1024CrossRef Dworak O (1991) Morphology of lymph nodes in the resected rectum of patients with rectal carcinoma. Pathol Res Pract 187(8):1020–1024CrossRef
35.
go back to reference Schaap DP, Boogerd LSF, Konishi T et al (2021) Rectal cancer lateral lymph nodes: multicentre study of the impact of obturator and internal iliac nodes on oncological outcomes. Br J Surg 108(2):205–213CrossRef Schaap DP, Boogerd LSF, Konishi T et al (2021) Rectal cancer lateral lymph nodes: multicentre study of the impact of obturator and internal iliac nodes on oncological outcomes. Br J Surg 108(2):205–213CrossRef
36.
go back to reference Ogura A, Konishi T, Cunningham C et al (2019) Neoadjuvant (chemo)radiotherapy with total mesorectal excision only is not sufficient to prevent lateral local recurrence in enlarged nodes: results of the multicenter lateral node study of patients with low cT3/4 rectal cancer. J Clin Oncol 37(1):33–43CrossRef Ogura A, Konishi T, Cunningham C et al (2019) Neoadjuvant (chemo)radiotherapy with total mesorectal excision only is not sufficient to prevent lateral local recurrence in enlarged nodes: results of the multicenter lateral node study of patients with low cT3/4 rectal cancer. J Clin Oncol 37(1):33–43CrossRef
37.
go back to reference Ogura A, Konishi T, Beets GL et al (2019) Lateral node study consortium. Lateral nodal features on restaging magnetic resonance imaging associated with lateral local recurrence in low rectal cancer after neoadjuvant chemoradiotherapy or radiotherapy. JAMA Surg 154(9):192172CrossRef Ogura A, Konishi T, Beets GL et al (2019) Lateral node study consortium. Lateral nodal features on restaging magnetic resonance imaging associated with lateral local recurrence in low rectal cancer after neoadjuvant chemoradiotherapy or radiotherapy. JAMA Surg 154(9):192172CrossRef
38.
go back to reference Yagi R, Shimada Y, Kameyama H et al (2016) Clinical significance of extramural tumor deposits in the lateral pelvic lymph node area in low rectal cancer: a retrospective study at two institutions. Ann Surg Oncol 23(Suppl 4):552–558CrossRef Yagi R, Shimada Y, Kameyama H et al (2016) Clinical significance of extramural tumor deposits in the lateral pelvic lymph node area in low rectal cancer: a retrospective study at two institutions. Ann Surg Oncol 23(Suppl 4):552–558CrossRef
39.
go back to reference Akiyoshi T, Watanabe T, Miyata S et al (2012) Results of a Japanese nationwide multi-institutional study on lateral pelvic lymph node metastasis in low rectal cancer: is it regional or distant disease? Ann Surg 255(6):1129–1134CrossRef Akiyoshi T, Watanabe T, Miyata S et al (2012) Results of a Japanese nationwide multi-institutional study on lateral pelvic lymph node metastasis in low rectal cancer: is it regional or distant disease? Ann Surg 255(6):1129–1134CrossRef
41.
go back to reference Lambregts DMJ, Boellaard TN, Beets-Tan RGH (2019) Response evaluation after neoadjuvant treatment for rectal cancer using modern MR imaging: a pictorial review. Insights Imaging 10(1):15CrossRef Lambregts DMJ, Boellaard TN, Beets-Tan RGH (2019) Response evaluation after neoadjuvant treatment for rectal cancer using modern MR imaging: a pictorial review. Insights Imaging 10(1):15CrossRef
42.
go back to reference Barbaro B, Vitale R, Leccisotti L et al (2010) Restaging locally advanced rectal cancer with MR imaging after chemoradiation therapy. Radiographics 30(3):699–716CrossRef Barbaro B, Vitale R, Leccisotti L et al (2010) Restaging locally advanced rectal cancer with MR imaging after chemoradiation therapy. Radiographics 30(3):699–716CrossRef
43.
go back to reference Van der Paardt MP, Zagers MB, Beets-Tan RG et al (2013) Patients who undergo preoperative chemoradiotherapy for locally advanced rectal cancer restaged by using diagnostic MR imaging: a systematic review and meta-analysis. Radiology 269(1):101–112CrossRef Van der Paardt MP, Zagers MB, Beets-Tan RG et al (2013) Patients who undergo preoperative chemoradiotherapy for locally advanced rectal cancer restaged by using diagnostic MR imaging: a systematic review and meta-analysis. Radiology 269(1):101–112CrossRef
44.
go back to reference Schurink NW, Lambregts DMJ, Beets-Tan RGH (2019) Diffusion-weighted imaging in rectal cancer: current applications and future perspectives. Br J Radiol 92(1096):20180655CrossRef Schurink NW, Lambregts DMJ, Beets-Tan RGH (2019) Diffusion-weighted imaging in rectal cancer: current applications and future perspectives. Br J Radiol 92(1096):20180655CrossRef
45.
go back to reference Vliegen RF, Beets GL, Lammering G et al (2008) Mesorectal fascia invasion after neoadjuvant chemotherapy and radiation therapy for locally advanced rectal cancer: accuracy of MR imaging for prediction. Radiology 246(2):454–462CrossRef Vliegen RF, Beets GL, Lammering G et al (2008) Mesorectal fascia invasion after neoadjuvant chemotherapy and radiation therapy for locally advanced rectal cancer: accuracy of MR imaging for prediction. Radiology 246(2):454–462CrossRef
46.
go back to reference Siddiqui MR, Gormly KL, Bhoday J et al (2016) Interobserver agreement of radiologists assessing the response of rectal cancers to preoperative chemoradiation using the MRI tumour regression grading (mrTRG). Clin Radiol 71(9):854–862CrossRef Siddiqui MR, Gormly KL, Bhoday J et al (2016) Interobserver agreement of radiologists assessing the response of rectal cancers to preoperative chemoradiation using the MRI tumour regression grading (mrTRG). Clin Radiol 71(9):854–862CrossRef
47.
go back to reference van der Valk MJM, Hilling DE, Bastiaannet E et al (2018) Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch and Wait Database (IWWD): an international multicentre registry study. Lancet 391(10139):2537–2545CrossRef van der Valk MJM, Hilling DE, Bastiaannet E et al (2018) Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch and Wait Database (IWWD): an international multicentre registry study. Lancet 391(10139):2537–2545CrossRef
48.
go back to reference Hupkens BJP, Maas M, Martens MH et al (2017) MRI surveillance for the detection of local recurrence in rectal cancer after transanal endoscopic microsurgery. Eur Radiol 27(12):4960–4969CrossRef Hupkens BJP, Maas M, Martens MH et al (2017) MRI surveillance for the detection of local recurrence in rectal cancer after transanal endoscopic microsurgery. Eur Radiol 27(12):4960–4969CrossRef
49.
go back to reference Sagebiel TL, Faria SC, Balachandran A et al (2011) Pelvic reconstruction with omental and VRAM flaps: anatomy, surgical technique, normal postoperative findings, and complications. Radiographics 31(7):2005–2019CrossRef Sagebiel TL, Faria SC, Balachandran A et al (2011) Pelvic reconstruction with omental and VRAM flaps: anatomy, surgical technique, normal postoperative findings, and complications. Radiographics 31(7):2005–2019CrossRef
50.
go back to reference Borstlap WAA, Westerduin E, Aukema TS et al (2017) Anastomotic leakage and chronic presacral sinus formation after low anterior resection: results from a large cross-sectional study. Ann Surg 266(5):870–877CrossRef Borstlap WAA, Westerduin E, Aukema TS et al (2017) Anastomotic leakage and chronic presacral sinus formation after low anterior resection: results from a large cross-sectional study. Ann Surg 266(5):870–877CrossRef
Metadata
Title
MRI anatomy of the rectum: key concepts important for rectal cancer staging and treatment planning
Authors
Nino Bogveradze
Petur Snaebjornsson
Brechtje A. Grotenhuis
Baukelien van Triest
Max J. Lahaye
Monique Maas
Geerard L. Beets
Regina G. H. Beets-Tan
Doenja M. J. Lambregts
Publication date
01-12-2023
Publisher
Springer Vienna
Published in
Insights into Imaging / Issue 1/2023
Electronic ISSN: 1869-4101
DOI
https://doi.org/10.1186/s13244-022-01348-8

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