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01-06-2020 | Magnetic Resonance Imaging | Original Article

Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion

Authors: Mohammed Salman Shazeeb, Robert M. King, Olivia W. Brooks, Ajit S. Puri, Nils Henninger, Johannes Boltze, Matthew J. Gounis

Published in: Translational Stroke Research | Issue 3/2020

Abstract

Mechanical thrombectomy for the treatment of ischemic stroke shows high rates of recanalization; however, some patients still have a poor clinical outcome. A proposed reason for this relates to the fact that the ischemic infarct growth differs significantly between patients. While some patients demonstrate rapid evolution of their infarct core (fast evolvers), others have substantial potentially salvageable penumbral tissue even hours after initial vessel occlusion (slow evolvers). We show that the dog middle cerebral artery occlusion model recapitulates this key aspect of human stroke rendering it a highly desirable model to develop novel multimodal treatments to improve clinical outcomes. Moreover, this model is well suited to develop novel image analysis techniques that allow for improved lesion evolution prediction; we provide proof-of-concept that MRI perfusion-based time-to-peak maps can be utilized to predict the rate of infarct growth as validated by apparent diffusion coefficient-derived lesion maps allowing reliable classification of dogs into fast versus slow evolvers enabling more robust study design for interventional research.

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Title: Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion
Authors: Mohammed Salman Shazeeb
Robert M. King
Olivia W. Brooks
Ajit S. Puri
Nils Henninger
Johannes Boltze
Matthew J. Gounis
Publication date: 01-06-2020
Publisher: Springer US
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Stroke
Published in: Translational Stroke Research / Issue 3/2020
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-019-00732-9

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Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion

Abstract

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Abstract

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