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Neurological Sciences

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15-07-2022 | Magnetic Resonance Imaging | Original Article

Functional brain changes in Parkinson’s disease: a whole brain ALE study

Authors: Lihua Gu, Hao Shu, Hui Xu, Yanjuan Wang

Published in: Neurological Sciences | Issue 10/2022

Abstract

Background

Resting-state functional magnetic resonance imaging (rs-fMRI) was widely used as an effective tool in the diagnosis of neurodegenerative diseases. However, prior rs-fMRI studies reported inconsistent results for comparison between Parkinson’s disease (PD) and healthy controls (HC).

Methods

We searched studies published before December 2021 in databases (PubMed, Web of Science, and Google Scholar). An activation likelihood estimation (ALE) meta-analysis was made for functional changes in PD.

Results

The study finally included 25 studies (including 973 PD patients and 766 HC). PD patients showed reduced amplitude of low frequency fluctuations (ALFF) in the left superior temporal gyrus (STG), the left superior frontal gyrus (SFG), the left medial frontal gyrus (MFG), the left precuneus (PCUN), and the right lentiform nucleus, compared to HC. PD patients showed increased ALFF in the right SFG, the left superior parietal lobule (SPL), the left STG, the right fusiform gyrus, the left inferior temporal gyrus (ITG), and the right parahippocampal gyrus (PHG), compared to HC. PD patients showed reduced regional homogeneity (ReHo) in the right declive, the right MFG, the left culmen, and the left thalamus, compared to HC. PD patients showed increased ReHo in the right SFG, compared to HC. Additionally, PD patients showed reduced functional connectivity (FC) in the right posterior cingulate (PCG), compared to HC.

Conclusions

The present ALE analysis has confirmed functional deficits in motor-, emotion-, and cognition-related regions in PD. Deficits in these regions in rs-fMRI studies could play a role in early diagnosis of PD.

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Title: Functional brain changes in Parkinson’s disease: a whole brain ALE study
Authors: Lihua Gu
Hao Shu
Hui Xu
Yanjuan Wang
Publication date: 15-07-2022
Publisher: Springer International Publishing
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Parkinson's Disease
Published in: Neurological Sciences / Issue 10/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-06272-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Functional brain changes in Parkinson’s disease: a whole brain ALE study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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