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BMC Neurology

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Open Access 01-12-2021 | Magnetic Resonance Imaging | Case report

Dynamic analysis of CSF1R-related leukoencephalopathy on magnetic resonance imaging: a case report

Authors: Huasheng Huang, Liming Cao, Hong Chen

Published in: BMC Neurology | Issue 1/2021

Abstract

Background

Colony-stimulating factor 1 receptor (CSF1R)-related leukoencephalopathy is a rare and rapidly progressive leukoencephalopathy characterized by cognitive, motor, and neuropsychiatric symptoms, which is often misdiagnosed. Magnetic resonance imaging (MRI) signs and follow-up MRI of CSF1R-related leukoencephalopathy could help in establishing a diagnosis, but these features are not widely known by general neurologists.

Case presentation

A 34-year-old man was admitted for progressive weakness of the right limbs over 8 months. His father and sister had a similar clinical evolution. The primary neurological signs were hemiplegia, cognitive decline, dysarthria, pyramidal signs, ataxia and parkinsonism, and rapid disease progression. Cerebrospinal fluid analysis results were normal. Despite receiving treatment for improving cerebral metabolism and relieving the muscle spasm, his symptoms did not improve significantly. Brain MRI showed lesions concentrated in the corpus callosum and the deep white matter of the bilateral parieto-occipital lobes, periventricular areas, and corticospinal tracts. There was an enhanced lesion after a gadolinium-enhanced MRI scan. Over the 8-month progression, the lesions always exhibited restricted diffusion. The diffuse lesions gradually increased as the disease progressed. Genetic sequencing results showed a novel heterozygous missense mutation (c.2267 T > C p.L756P) in the CSF1R gene. The patient was treated with citicoline and idebenone for 4 days to improve cerebral metabolism, but his symptoms did not improve significantly.

Conclusion

The multiple lesions involving the pyramidal tract and white matter showed continuously restricted diffusion on brain imaging and gradually increased with disease progression.

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Title: Dynamic analysis of CSF1R-related leukoencephalopathy on magnetic resonance imaging: a case report
Authors: Huasheng Huang
Liming Cao
Hong Chen
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Multiple Sclerosis
Published in: BMC Neurology / Issue 1/2021
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-021-02182-z

2024 ASCO Annual Meeting

Springer Medicine

Dynamic analysis of CSF1R-related leukoencephalopathy on magnetic resonance imaging: a case report

Abstract

Background

Case presentation

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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