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Open Access 01-12-2021 | Magnetic Resonance Imaging | Research article

Altered local and matrix functional connectivity in depressed essential tremor patients

Authors: Xiyue Duan, Zhou Fang, Li Tao, Huiyue Chen, Xiaoyu Zhang, Yufen Li, Hansheng Wang, Aotian Li, Xueyan Zhang, Ya Pang, Min Gu, Jiahui Wu, Fajin Lv, Tianyou Luo, Oumei Cheng, Jin Luo, Zheng Xiao, Weidong Fang

Published in: BMC Neurology | Issue 1/2021

Abstract

Background

Depression in essential tremor (ET) has been constantly studied and reported, while the associated brain activity changes remain unclear. Recently, regional homogeneity (ReHo), a voxel-wise local functional connectivity (FC) analysis of resting-state functional magnetic resonance imaging, has provided a promising way to observe spontaneous brain activity.

Methods

Local FC analyses were performed in forty-one depressed ET patients, 49 non-depressed ET patients and 43 healthy controls (HCs), and then matrix FC and clinical depression severity correlation analyses were further performed to reveal spontaneous neural activity changes in depressed ET patients.

Results

Compared with the non-depressed ET patients, the depressed ET patients showed decreased ReHo in the bilateral cerebellum lobules IX, and increased ReHo in the bilateral anterior cingulate cortices and middle prefrontal cortices. Twenty-five significant changes of ReHo clusters were observed in the depressed ET patients compared with the HCs, and matrix FC analysis further revealed that inter-ROI FC differences were also observed in the frontal-cerebellar-anterior cingulate cortex pathway. Correlation analyses showed that clinical depression severity was positively correlated with the inter-ROI FC values between the anterior cingulate cortex and bilateral middle prefrontal cortices and was negatively correlated with the inter-ROI FC values of the anterior cingulate cortex and bilateral cerebellum lobules IX.

Conclusion

Our findings revealed local and inter-ROI FC differences in frontal-cerebellar-anterior cingulate cortex circuits in depressed ET patients, and among these regions, the cerebellum lobules IX, middle prefrontal cortices and anterior cingulate cortices could function as pathogenic structures underlying depression in ET patients.

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Title: Altered local and matrix functional connectivity in depressed essential tremor patients
Authors: Xiyue Duan
Zhou Fang
Li Tao
Huiyue Chen
Xiaoyu Zhang
Yufen Li
Hansheng Wang
Aotian Li
Xueyan Zhang
Ya Pang
Min Gu
Jiahui Wu
Fajin Lv
Tianyou Luo
Oumei Cheng
Jin Luo
Zheng Xiao
Weidong Fang
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Tremor
Mood Disorders
Affective Disorder
Published in: BMC Neurology / Issue 1/2021
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-021-02100-3

2024 ASCO Annual Meeting

Springer Medicine

Altered local and matrix functional connectivity in depressed essential tremor patients

Abstract

Background

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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