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European Radiology

Published in:

25-05-2022 | Magnetic Resonance Imaging | Magnetic Resonance

Adding liver R2* quantification to proton density fat fraction MRI of vertebral bone marrow improves the prediction of osteoporosis

Authors: Feng Lu, Yan-Jun Zhao, Jian-Ming Ni, Yu Jiang, Fang-Ming Chen, Zhong-Juan Wang, Zhui-Yang Zhang

Published in: European Radiology | Issue 10/2022

Abstract

Objectives

To assess the predictive value of the combination of bone marrow (BM) proton density fat fraction (PDFF) and liver R2* for osteopenia and osteoporosis and the additional role of liver R2*.

Methods

A total of 107 healthy women were included between June 2019 and January 2021. Each participant underwent dual-energy X-ray absorptiometry (DXA) and chemical shift-encoded 3.0-T MRI. PDFF measurements were performed for each lumbar vertebral body, and R2* measurements were performed in liver segments. Agreement among measurements was assessed by Bland-Altman analysis. Receiver operating characteristic (ROC) curves were generated to select optimised cut-offs for BM PDFF and liver R2*. Univariable and multivariable logistic regressions were performed. The C statistic and continuous net reclassification improvement (NRI) were adopted to explore the incremental predictive ability of liver R2*.

Results

Bone mass decreased in 42 cases (39.3%) and nonbone mass decreased in 65 cases (60.7%). There were significant differences among the age groups, menopausal status groups, PDFF > 45.0% groups, and R2* > 67.7 groups. Each measurement had good reproducibility. The odds ratios (95% CIs) were 4.05 (1.22–13.43) for PDFF and 4.34 (1.41–13.35) for R2*. The C statistic (95% CI) without R2* was 0.888 (0.827–0.950), and with R2* was 0.900 (0.841–0.960). The NRI resulting from the combination of PDFF and R2* was 75.6% (p < 0.01).

Conclusion

The predictive improvement over the use of BM PDFF and other traditional risk factors demonstrates the potential of liver R2* as a biomarker for osteopenia and osteoporosis in healthy women.

Key Points

• Liver R2* is a biomarker for the assessment of osteopenia and osteoporosis.

• Liver R2* improved the ability to predict osteopenia and osteoporosis.

• The intra- and interobserver measurements showed high agreement.

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Title: Adding liver R2* quantification to proton density fat fraction MRI of vertebral bone marrow improves the prediction of osteoporosis
Authors: Feng Lu
Yan-Jun Zhao
Jian-Ming Ni
Yu Jiang
Fang-Ming Chen
Zhong-Juan Wang
Zhui-Yang Zhang
Publication date: 25-05-2022
Publisher: Springer Berlin Heidelberg
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Osteoporosis
Osteoporosis
Published in: European Radiology / Issue 10/2022
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-022-08861-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Adding liver R2* quantification to proton density fat fraction MRI of vertebral bone marrow improves the prediction of osteoporosis

Abstract

Objectives

Methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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