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Published in: Skeletal Radiology 10/2007

Open Access 01-10-2007 | Review Article

Magnetic resonance imaging of bone marrow in oncology, Part 1

Authors: Sinchun Hwang, David M. Panicek

Published in: Skeletal Radiology | Issue 10/2007

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Abstract

Magnetic resonance imaging plays an integral role in the detection and characterization of marrow lesions, planning for biopsy or surgery, and post-treatment follow-up. To evaluate findings in bone marrow on MR imaging, it is essential to understand the normal composition and distribution of bone marrow and the changes in marrow that occur with age, as well as the basis for the MR signals from marrow and the factors that affect those signals. The normal distribution of red and yellow marrow in the skeleton changes with age in a predictable sequence. Important factors that affect MR signals and allow detection of marrow lesions include alterations in fat–water distribution, destruction of bony trabeculae, and contrast enhancement. This two-part article reviews and illustrates these issues, with an emphasis on the practical application of MR imaging to facilitate differentiation of normal marrow, tumor, and treatment-related marrow changes in oncology patients.
Literature
1.
go back to reference Steiner RM, Mitchell DG, Rao VM, Schweitzer ME. Magnetic resonance imaging of diffuse bone marrow disease. Radiol Clin North Am 1993; 31: 383–409.PubMed Steiner RM, Mitchell DG, Rao VM, Schweitzer ME. Magnetic resonance imaging of diffuse bone marrow disease. Radiol Clin North Am 1993; 31: 383–409.PubMed
2.
go back to reference Snyder WS, Cook MJ, Nasset ES, Karhausen LR, Howells CP, Tipton IH. International Commission on Radiological Protection. Report of the task group on reference man. Oxford: Pergamon; 1975. pp. 79–98. Snyder WS, Cook MJ, Nasset ES, Karhausen LR, Howells CP, Tipton IH. International Commission on Radiological Protection. Report of the task group on reference man. Oxford: Pergamon; 1975. pp. 79–98.
3.
go back to reference Vande Berg BC, Malghem J, Lecouvet FE, Maldague B. Magnetic resonance imaging of the normal bone marrow. Skeletal Radiol 1998; 27: 471–483.CrossRef Vande Berg BC, Malghem J, Lecouvet FE, Maldague B. Magnetic resonance imaging of the normal bone marrow. Skeletal Radiol 1998; 27: 471–483.CrossRef
4.
go back to reference Piney A. The anatomy of the bone marrow: with special reference to the distribution of the red marrow. BMJ 1922; 28: 792–795. Piney A. The anatomy of the bone marrow: with special reference to the distribution of the red marrow. BMJ 1922; 28: 792–795.
5.
go back to reference Moore SG, Dawson KL. Red and yellow marrow in the femur: age-related changes in appearance at MR imaging. Radiology 1990; 175: 219–223.PubMed Moore SG, Dawson KL. Red and yellow marrow in the femur: age-related changes in appearance at MR imaging. Radiology 1990; 175: 219–223.PubMed
6.
go back to reference Ricci C, Cova M, Kang YS, et al. Normal age-related patterns of cellular and fatty bone marrow distribution in the axial skeleton: MR imaging study. Radiology 1990; 177: 83–88.PubMed Ricci C, Cova M, Kang YS, et al. Normal age-related patterns of cellular and fatty bone marrow distribution in the axial skeleton: MR imaging study. Radiology 1990; 177: 83–88.PubMed
7.
go back to reference Hartsock RJ, Smith EB, Petty CS. Normal variations with aging of the amount of hematopoietic tissue in bone marrow from the anterior iliac crest. A study made from 177 cases of sudden death examined by necropsy. Am J Clin Pathol 1965; 43: 326–331.PubMed Hartsock RJ, Smith EB, Petty CS. Normal variations with aging of the amount of hematopoietic tissue in bone marrow from the anterior iliac crest. A study made from 177 cases of sudden death examined by necropsy. Am J Clin Pathol 1965; 43: 326–331.PubMed
8.
go back to reference Shellock FG, Morris E, Deutsch AL, Mink JH, Kerr R, Boden SD. Hematopoietic bone marrow hyperplasia: high prevalence on MR images of the knee in asymptomatic marathon runners. Am J Roentgenol 1992; 158: 335–338. Shellock FG, Morris E, Deutsch AL, Mink JH, Kerr R, Boden SD. Hematopoietic bone marrow hyperplasia: high prevalence on MR images of the knee in asymptomatic marathon runners. Am J Roentgenol 1992; 158: 335–338.
9.
go back to reference Poulton TB, Murphy WD, Duerk JL, Chapek CC, Feiglin DH. Bone marrow reconversion in adults who are smokers: MR imaging findings. Am J Roentgenol 1993; 161: 1217–1221. Poulton TB, Murphy WD, Duerk JL, Chapek CC, Feiglin DH. Bone marrow reconversion in adults who are smokers: MR imaging findings. Am J Roentgenol 1993; 161: 1217–1221.
10.
go back to reference Stabler A, Doma AB, Baur A, Kruger A, Reiser MF. Reactive bone marrow changes in infectious spondylitis: quantitative assessment with MR imaging. Radiology 2000; 217: 863–868.PubMed Stabler A, Doma AB, Baur A, Kruger A, Reiser MF. Reactive bone marrow changes in infectious spondylitis: quantitative assessment with MR imaging. Radiology 2000; 217: 863–868.PubMed
11.
go back to reference Vande Berg BC, Lecouvet FE, Galant C, Maldague BE, Malghem J. Normal variants and frequent marrow alterations that simulate bone marrow lesions at MR imaging. Radiol Clin North Am 2005; 43:761–770.CrossRef Vande Berg BC, Lecouvet FE, Galant C, Maldague BE, Malghem J. Normal variants and frequent marrow alterations that simulate bone marrow lesions at MR imaging. Radiol Clin North Am 2005; 43:761–770.CrossRef
12.
13.
14.
go back to reference Panicek DM, Schwartz LH. MR imaging of bone marrow in patients with musculoskeletal tumors. Sarcoma 1999; 3: 37–41.CrossRef Panicek DM, Schwartz LH. MR imaging of bone marrow in patients with musculoskeletal tumors. Sarcoma 1999; 3: 37–41.CrossRef
15.
go back to reference Disler DG, McCauley TR, Ratner LM, Kesack CD, Cooper JA. In-phase and out-of-phase MR imaging of bone marrow: prediction of neoplasia based on the detection of coexistent fat and water. Am J Roentgenol 1997; 169: 1439–1447. Disler DG, McCauley TR, Ratner LM, Kesack CD, Cooper JA. In-phase and out-of-phase MR imaging of bone marrow: prediction of neoplasia based on the detection of coexistent fat and water. Am J Roentgenol 1997; 169: 1439–1447.
16.
go back to reference Zajick DC Jr, Morrison WB, Schweitzer ME, Parellada JA, Carrino JA. Benign and malignant processes: normal values and differentiation with chemical shift MR imaging in vertebral marrow. Radiology 2005; 237: 590–596.PubMedCrossRef Zajick DC Jr, Morrison WB, Schweitzer ME, Parellada JA, Carrino JA. Benign and malignant processes: normal values and differentiation with chemical shift MR imaging in vertebral marrow. Radiology 2005; 237: 590–596.PubMedCrossRef
17.
go back to reference Erly WK, Oh ES, Outwater EK. The utility of in-phase/opposed-phase imaging in differentiating malignancy from acute benign compression fractures of the spine. Am J Neuroradiol 2006; 27: 1183–1188.PubMed Erly WK, Oh ES, Outwater EK. The utility of in-phase/opposed-phase imaging in differentiating malignancy from acute benign compression fractures of the spine. Am J Neuroradiol 2006; 27: 1183–1188.PubMed
18.
go back to reference Keller PJ, Hunter WW Jr, Schmalbrock P. Multisection fat-water imaging with chemical shift selective presaturation. Radiology 1987; 164: 539–541.PubMed Keller PJ, Hunter WW Jr, Schmalbrock P. Multisection fat-water imaging with chemical shift selective presaturation. Radiology 1987; 164: 539–541.PubMed
19.
go back to reference Mitchell DG, Vinitski S, Rifkin MD, Burk DL Jr. Sampling bandwidth and fat suppression: effects on long TR/TE MR imaging of the abdomen and pelvis at 1.5 T. Am J Roentgenol 1989; 153: 419–425. Mitchell DG, Vinitski S, Rifkin MD, Burk DL Jr. Sampling bandwidth and fat suppression: effects on long TR/TE MR imaging of the abdomen and pelvis at 1.5 T. Am J Roentgenol 1989; 153: 419–425.
20.
go back to reference Bushong S. Magnetic resonance imaging: physical and biological principles. 3rd edn. St. Louis: Mosby; 2003. Bushong S. Magnetic resonance imaging: physical and biological principles. 3rd edn. St. Louis: Mosby; 2003.
21.
go back to reference Mirowitz SA, Apicella P, Reinus WR, Hammerman AM. MR imaging of bone marrow lesions: relative conspicuousness on T1- weighted, fat-suppressed T2-weighted, and STIR images. Am J Roentgenol 1994; 162: 215–221. Mirowitz SA, Apicella P, Reinus WR, Hammerman AM. MR imaging of bone marrow lesions: relative conspicuousness on T1- weighted, fat-suppressed T2-weighted, and STIR images. Am J Roentgenol 1994; 162: 215–221.
22.
go back to reference Baur A, Reiser MF. Diffusion-weighted imaging of the musculoskeletal system in humans. Skeletal Radiol 2000; 29: 555–562.PubMedCrossRef Baur A, Reiser MF. Diffusion-weighted imaging of the musculoskeletal system in humans. Skeletal Radiol 2000; 29: 555–562.PubMedCrossRef
23.
go back to reference Baur A, Stabler A, Huber A, Reiser M. Diffusion-weighted magnetic resonance imaging of spinal bone marrow. Semin Musculoskelet Radiol 2001; 5: 35–42.PubMedCrossRef Baur A, Stabler A, Huber A, Reiser M. Diffusion-weighted magnetic resonance imaging of spinal bone marrow. Semin Musculoskelet Radiol 2001; 5: 35–42.PubMedCrossRef
24.
go back to reference Plecha DM. Imaging of bone marrow disease in the spine. Semin Musculoskelet Radiol 2000; 4: 321–327.PubMedCrossRef Plecha DM. Imaging of bone marrow disease in the spine. Semin Musculoskelet Radiol 2000; 4: 321–327.PubMedCrossRef
25.
go back to reference Baur A, Stabler A, Bruning R, et al. Diffusion-weighted MR imaging of bone marrow: differentiation of benign versus pathologic compression fractures. Radiology 1998; 207: 349–356.PubMed Baur A, Stabler A, Bruning R, et al. Diffusion-weighted MR imaging of bone marrow: differentiation of benign versus pathologic compression fractures. Radiology 1998; 207: 349–356.PubMed
26.
go back to reference Castillo M, Arbelaez A, Smith JK, Fisher LL. Diffusion-weighted MR imaging offers no advantage over routine noncontrast MR imaging in the detection of vertebral metastases. AJNR Am J Neuroradiol 2000; 21: 948–953.PubMed Castillo M, Arbelaez A, Smith JK, Fisher LL. Diffusion-weighted MR imaging offers no advantage over routine noncontrast MR imaging in the detection of vertebral metastases. AJNR Am J Neuroradiol 2000; 21: 948–953.PubMed
27.
go back to reference Yasumoto M, Nonomura Y, Yoshimura R, et al. MR detection of iliac bone marrow involvement by malignant lymphoma with various MR sequences including diffusion-weighted echo-planar imaging. Skeletal Radiol 2002; 31: 263–269.PubMedCrossRef Yasumoto M, Nonomura Y, Yoshimura R, et al. MR detection of iliac bone marrow involvement by malignant lymphoma with various MR sequences including diffusion-weighted echo-planar imaging. Skeletal Radiol 2002; 31: 263–269.PubMedCrossRef
28.
go back to reference Takahara T, Imai Y, Yamashita T, Yasuda S, Nasu S, Van Cauteren M. Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing, STIR and high resolution 3D display. Radiat Med 2004; 22: 275–282.PubMed Takahara T, Imai Y, Yamashita T, Yasuda S, Nasu S, Van Cauteren M. Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing, STIR and high resolution 3D display. Radiat Med 2004; 22: 275–282.PubMed
29.
go back to reference Sebag GH, Moore SG. Effect of trabecular bone on the appearance of marrow in gradient-echo imaging of the appendicular skeleton. Radiology 1990; 174: 855–859.PubMed Sebag GH, Moore SG. Effect of trabecular bone on the appearance of marrow in gradient-echo imaging of the appendicular skeleton. Radiology 1990; 174: 855–859.PubMed
30.
go back to reference Hendrick RE, Haacke EM. Basic physics of MR contrast agents and maximization of image contrast. J Magn Reson Imaging 1993; 3: 137–148.PubMedCrossRef Hendrick RE, Haacke EM. Basic physics of MR contrast agents and maximization of image contrast. J Magn Reson Imaging 1993; 3: 137–148.PubMedCrossRef
31.
go back to reference Montazel JL, Divine M, Lepage E, Kobeiter H, Breil S, Rahmouni A. Normal spinal bone marrow in adults: dynamic gadolinium-enhanced MR imaging. Radiology 2003; 229: 703–709.PubMedCrossRef Montazel JL, Divine M, Lepage E, Kobeiter H, Breil S, Rahmouni A. Normal spinal bone marrow in adults: dynamic gadolinium-enhanced MR imaging. Radiology 2003; 229: 703–709.PubMedCrossRef
32.
go back to reference Chen W, Shih T, Chen R, et al. Vertebral bone marrow perfusion evaluated with dynamic contrast-enhanced MR imaging: significance of aging and sex. Radiology 2001; 220: 213–218.PubMed Chen W, Shih T, Chen R, et al. Vertebral bone marrow perfusion evaluated with dynamic contrast-enhanced MR imaging: significance of aging and sex. Radiology 2001; 220: 213–218.PubMed
33.
go back to reference Daldrup-Link HE, Rummeny EJ, Ihssen B, Kienast J, Link TM. Iron-oxide-enhanced MR imaging of bone marrow in patients with non-Hodgkin’s lymphoma: differentiation between tumor infiltration and hypercellular bone marrow. Eur Radiol 2002; 12: 1557–1566.PubMedCrossRef Daldrup-Link HE, Rummeny EJ, Ihssen B, Kienast J, Link TM. Iron-oxide-enhanced MR imaging of bone marrow in patients with non-Hodgkin’s lymphoma: differentiation between tumor infiltration and hypercellular bone marrow. Eur Radiol 2002; 12: 1557–1566.PubMedCrossRef
34.
go back to reference Metz S, Lohr S, Settles M, et al. Ferumoxtran-10-enhanced MR imaging of the bone marrow before and after conditioning therapy in patients with non-Hodgkin lymphomas. Eur Radiol 2006;16:598–607.PubMedCrossRef Metz S, Lohr S, Settles M, et al. Ferumoxtran-10-enhanced MR imaging of the bone marrow before and after conditioning therapy in patients with non-Hodgkin lymphomas. Eur Radiol 2006;16:598–607.PubMedCrossRef
35.
go back to reference Levine CD, Schweitzer ME, Ehrlich SM. Pelvic marrow in adults. Skeletal Radiol 1994; 23: 343–347.PubMedCrossRef Levine CD, Schweitzer ME, Ehrlich SM. Pelvic marrow in adults. Skeletal Radiol 1994; 23: 343–347.PubMedCrossRef
Metadata
Title
Magnetic resonance imaging of bone marrow in oncology, Part 1
Authors
Sinchun Hwang
David M. Panicek
Publication date
01-10-2007
Publisher
Springer-Verlag
Published in
Skeletal Radiology / Issue 10/2007
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-007-0309-3

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