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Open Access 01-12-2023 | Original Article

Magnetic resonance elastography in evaluation of liver fibrosis in children with chronic liver disease

Authors: Duygu Demirtaş, Emre Ünal, İlkay S. İdilman, Zuhal Akçören, Mehmet Akif Göktaş, Meryem Seda Boyraz, Sevilay Karahan, Diclehan Orhan, Mithat Haliloğlu, Muşturay Karçaaltıncaba, Hasan Özen

Published in: Insights into Imaging | Issue 1/2023

Abstract

Background

Magnetic resonance elastography (MRE) has been used to stage liver fibrosis in adults. We aimed to assess the agreement between the Ishak scoring system and magnetic resonance elastography-measured liver stiffness (MRE-LS) in children. This study included all the children who underwent abdominal MRE and liver biopsies between February 2018 and January 2021. The correlation between MRE-LS and Ishak fibrosis stage, MRE parameters, and clinical and biochemical markers affecting this relationship was investigated.

Results

A total of 52 patients (31 male; a median age of 11.8 years) were included in the study. The MRE-LS values were significantly different between Ishak fibrosis stages (p = 0.036). With a cut-off value of 2.97 kilopascals, MRE-LS had sensitivity, specificity, PPV, NPV and accuracy values of 90.9%, 82.9%, 58.8%, 97.1%, and 84.6%, respectively, for differentiating mild/moderate fibrosis (F0, 1, 2, 3) from severe fibrosis (F ≥ 4). Although MRE-LS was moderately correlated with Ishak fibrosis score and histological activity index and weakly correlated with aspartate aminotransferase, hepatic steatosis, and R2*, only Ishak fibrosis score was a significant predictor of MRE-LS. MRE-measured spleen stiffness was weakly correlated with the Ishak fibrosis score.

Conclusions

MRE has high sensitivity and specificity for evaluating liver fibrosis in children. MRE may be used to evaluate liver fibrosis in pediatric patients.

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Title: Magnetic resonance elastography in evaluation of liver fibrosis in children with chronic liver disease
Authors: Duygu Demirtaş
Emre Ünal
İlkay S. İdilman
Zuhal Akçören
Mehmet Akif Göktaş
Meryem Seda Boyraz
Sevilay Karahan
Diclehan Orhan
Mithat Haliloğlu
Muşturay Karçaaltıncaba
Hasan Özen
Publication date: 01-12-2023
Publisher: Springer Vienna
Published in: Insights into Imaging / Issue 1/2023
Electronic ISSN: 1869-4101
DOI: https://doi.org/10.1186/s13244-023-01390-0

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Springer Medicine

Magnetic resonance elastography in evaluation of liver fibrosis in children with chronic liver disease

Abstract

Background

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Results

Conclusions

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