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Head & Neck Oncology
Published in: Head & Neck Oncology 1/2009

Open Access 01-12-2009 | Case report

MAGE-A as a novel approach in the diagnostic accuracy of oral squamous cell cancer: a case report

Authors: Philipp Metzler, Nur Mollaoglu, Stephan Schwarz, Friedrich W Neukam, Emeka Nkenke, Jutta Ries

Published in: Head & Neck Oncology | Issue 1/2009

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Abstract

Background

The aim of this case report is to introduce the combined use of brush biopsy and measurement of MAGE-A expression in the diagnosis of oral squamous cell carcinoma (OSCC).

Case report

We report of a 49-year old male patient who was referred to our department with a persistent-suspicious looking leukoplakia. Brush biopsy and an incisional biopsy were performed following clinical diagnosis. Histopathological examination revealed no malignancy. Expression analysis of melanoma-associated antigens A (MAGE-A) using real time RT-PCR was applied to brush biopsy materials because of the high prevalence of MAGE-A determined previously in OSCC's. Results indicated significant MAGE-A3 and A4 expression pattern. Therefore, the lesion was excised completely and an early invasive carcinoma was identified.

Conclusion

These results emphasize the role of brush biopsy using a tumor marker with a high expression frequency combined with a high sensitive and high specific detection system in the early diagnosis of OSCC, particularly in widespread leukoplakias.
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Metadata
Title
MAGE-A as a novel approach in the diagnostic accuracy of oral squamous cell cancer: a case report
Authors
Philipp Metzler
Nur Mollaoglu
Stephan Schwarz
Friedrich W Neukam
Emeka Nkenke
Jutta Ries
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Head & Neck Oncology / Issue 1/2009
Electronic ISSN: 1758-3284
DOI
https://doi.org/10.1186/1758-3284-1-39

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