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Japanese Journal of Ophthalmology
Published in: Japanese Journal of Ophthalmology 4/2020

01-07-2020 | Macular Degeneration | Clinical Investigation

Macular atrophy after aflibercept therapy for neovascular age-related macular degeneration: outcomes of Japanese multicenter study

Authors: Hideki Koizumi, Akiko Yamamoto, Masashi Ogasawara, Ichiro Maruko, Taiji Hasegawa, Kanako Itagaki, Tetsuju Sekiryu, Annabelle A. Okada, Tomohiro Iida

Published in: Japanese Journal of Ophthalmology | Issue 4/2020

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Abstract

Purpose

To evaluate the development and rate of growth in macular atrophy after intravitreal injections of aflibercept (IVAs) for neovascular age-related macular degeneration (AMD) over a 2-year period.

Study design

Retrospective, interventional, consecutive case series.

Methods

This study included 94 eyes of 92 patients with treatment-naïve AMD involving the foveal center treated with IVAs at 3 university hospitals in Japan. The patients underwent IVAs bimonthly after 3 initial monthly doses in the first year. The protocol was converted to a treat-and-extend regimen in the second year. The incidence and growth rate of macular atrophy were quantified based on hypoautofluorescence detected by fundus autofluorescence images. Additionally, possible background factors related to the development and rate of growth of macular atrophy were investigated.

Results

Of 94 eyes, 39 (41.5%) had typical AMD and 55 (58.5%) had polypoidal choroidal vasculopathy. Ten eyes (10.6%) had macular atrophy at the baseline. Of the remaining 84 eyes, 14 (16.7%) had developed new macular atrophy at 2 years, the square root of the growth rate of atrophy was 0.52 mm/year. In multivariate analyses, a poorer best-corrected visual acuity (P = 0.01) and the presence of intraretinal fluid (P = 0.04) at baseline were found to be the independent predictors for the development of macular atrophy. No factors were found that were significantly related to the growth rate of the macular atrophy.

Conclusions

Our study determined the incidence and rate of growth of macular atrophy after IVAs for neovascular AMD in clinical settings. Eyes with vision reduction and intraretinal fluid at the baseline develop macular atrophy more frequently after IVAs for neovascular AMD.
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Metadata
Title
Macular atrophy after aflibercept therapy for neovascular age-related macular degeneration: outcomes of Japanese multicenter study
Authors
Hideki Koizumi
Akiko Yamamoto
Masashi Ogasawara
Ichiro Maruko
Taiji Hasegawa
Kanako Itagaki
Tetsuju Sekiryu
Annabelle A. Okada
Tomohiro Iida
Publication date
01-07-2020
Publisher
Springer Japan
Published in
Japanese Journal of Ophthalmology / Issue 4/2020
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI
https://doi.org/10.1007/s10384-020-00745-0

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