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Journal of Ocular Biology, Diseases, and Informatics

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Open Access 01-03-2008

Macular and serum carotenoid concentrations in patients with malabsorption syndromes

Authors: Matthew S. Ward, Da You Zhao, Paul S. Bernstein

Published in: Journal of Ocular Biology, Diseases, and Informatics | Issue 1/2008

Abstract

The carotenoids lutein and zeaxanthin are believed to protect the human macula by absorbing blue light and quenching free radicals. Intestinal malabsorption syndromes such as celiac and Crohn’s disease are known to cause deficiencies of lipid-soluble nutrients. We hypothesized that subjects with nutrient malabsorption syndromes will demonstrate lower carotenoid levels in the macula and blood, and that these lower levels may correlate with early-onset maculopathy. Resonance Raman spectrographic (RRS) measurements of macular carotenoid levels were collected from subjects with and without a history of malabsorption syndromes. Carotenoids were extracted from serum and analyzed by high performance liquid chromatography (HPLC). Subjects with malabsorption (n = 22) had 37% lower levels of macular carotenoids on average versus controls (n = 25, P < 0.001). Malabsorption was not associated with decreased serum carotenoid levels. Convincing signs of early maculopathy were not observed. We conclude that intestinal malabsorption results in lower macular carotenoid levels.

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Title: Macular and serum carotenoid concentrations in patients with malabsorption syndromes
Authors: Matthew S. Ward
Da You Zhao
Paul S. Bernstein
Publication date: 01-03-2008
Publisher: Humana Press Inc
Published in: Journal of Ocular Biology, Diseases, and Informatics / Issue 1/2008
Electronic ISSN: 1936-8445
DOI: https://doi.org/10.1007/s12177-008-9008-0

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Springer Medicine

Macular and serum carotenoid concentrations in patients with malabsorption syndromes

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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