Top

Published in:

18-01-2024 | Original Contribution

Lysophosphatidic acid contributes to myocardial ischemia/reperfusion injury by activating TRPV1 in spinal cord

Authors: Chao Wu, Meiyan Sun, Muge Qile, Yu Zhang, Liu Liu, Xueying Cheng, Xiaoxiao Dai, Eric R. Gross, Ye Zhang, Shufang He

Published in: Basic Research in Cardiology | Issue 2/2024

Abstract

Lysophosphatidic acid (LPA) is a bioactive phospholipid that plays a crucial role in cardiovascular diseases. Here, we question whether LPA contributes to myocardial ischemia/reperfusion (I/R) injury by acting on transient receptor potential vanilloid 1 (TRPV1) in spinal cord. By ligating the left coronary artery to establish an in vivo I/R mouse model, we observed a 1.57-fold increase in LPA level in the cerebrospinal fluid (CSF). The I/R-elevated CSF LPA levels were reduced by HA130, an LPA synthesis inhibitor, compared to vehicle treatment (4.74 ± 0.34 vs. 6.46 ± 0.94 μg/mL, p = 0.0014). Myocardial infarct size was reduced by HA130 treatment compared to the vehicle group (26 ± 8% vs. 46 ± 8%, p = 0.0001). To block the interaction of LPA with TRPV1 at the K710 site, we generated a K710N knock-in mouse model. The TRPV1^K710N mice were resistant to LPA-induced myocardial injury, showing a smaller infarct size relative to TRPV1^WT mice (28 ± 4% vs. 60 ± 7%, p < 0.0001). Additionally, a sequence-specific TRPV1 peptide targeting the K710 region produced similar protective effects against LPA-induced myocardial injury. Blocking the K710 region through K710N mutation or TRPV1 peptide resulted in reduced neuropeptides release and decreased activity of cardiac sensory neurons, leading to a decrease in cardiac norepinephrine concentration and the restoration of intramyocardial pro-survival signaling, namely protein kinase B/extracellular regulated kinase/glycogen synthase kinase-3β pathway. These findings suggest that the elevation of CSF LPA is strongly associated with myocardial I/R injury. Moreover, inhibiting the interaction of LPA with TRPV1 by blocking the K710 region uncovers a novel strategy for preventing myocardial ischemic injury.

Available only for authorised users

Albers HM, Dong A, van Meeteren LA, Egan DA, Sunkara M, van Tilburg EW, Schuurman K, van Tellingen O, Morris AJ, Smyth SS, Moolenaar WH, Ovaa H (2010) Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc Natl Acad Sci U S A 107:7257–7262. https://doi.org/10.1073/pnas.1001529107CrossRefPubMedPubMedCentral

Aoki J, Inoue A, Okudaira S (2008) Two pathways for lysophosphatidic acid production. Biochim Biophys Acta 1781:513–518. https://doi.org/10.1016/j.bbalip.2008.06.005CrossRefPubMed

Arun P, Wilder DM, Morris AJ, Sabbadini R, Long JB (2023) Cerebrospinal fluid levels of lysophosphatidic acids can provide suitable biomarkers of blast-induced traumatic brain injury. J Neurotrauma. https://doi.org/10.1089/neu.2023.0087CrossRefPubMed

Bitar L, Uphaus T, Thalman C, Muthuraman M, Gyr L, Ji H, Domingues M, Endle H, Groppa S, Steffen F, Koirala N, Fan W, Ibanez L, Heitsch L, Cruchaga C, Lee JM, Kloss F, Bittner S, Nitsch R, Zipp F, Vogt J (2022) Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke. Sci Transl Med 14:e0135. https://doi.org/10.1126/scitranslmed.abk0135CrossRef

Botker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, Efentakis P, Femmino S, Garcia-Dorado D, Giricz Z, Ibanez B, Iliodromitis E, Kaludercic N, Kleinbongard P, Neuhauser M, Ovize M, Pagliaro P, Rahbek-Schmidt M, Ruiz-Meana M, Schluter KD, Schulz R, Skyschally A, Wilder C, Yellon DM, Ferdinandy P, Heusch G (2018) Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol 113:39. https://doi.org/10.1007/s00395-018-0696-8CrossRefPubMedPubMedCentral

Cai L, Fan G, Wang F, Liu S, Li T, Cong X, Chun J, Chen X (2017) Protective role for LPA3 in cardiac hypertrophy induced by myocardial infarction but not by isoproterenol. Front Physiol 8:356. https://doi.org/10.3389/fphys.2017.00356CrossRefPubMedPubMedCentral

Canul-Sanchez JA, Hernandez-Araiza I, Hernandez-Garcia E, Llorente I, Morales-Lazaro SL, Islas LD, Rosenbaum T (2018) Different agonists induce distinct single-channel conductance states in TRPV1 channels. J Gen Physiol 150:1735–1746. https://doi.org/10.1085/jgp.201812141CrossRefPubMedPubMedCentral

Castrejon-Tellez V, Del Valle-Mondragon L, Perez-Torres I, Guarner-Lans V, Pastelin-Hernandez G, Ruiz-Ramirez A, Diaz-Juarez JA, Varela-Lopez E, Oidor-Chan VH, Vargas-Gonzalez A, Martinez-Memije R, Flores-Chavez P, Leon-Ruiz B, Arriaga-Carrillo S, Torres-Narvaez JC (2022) TRPV1 contributes to modulate the nitric oxide pathway and oxidative stress in the isolated and perfused rat heart during ischemia and reperfusion. Molecules 27:1031. https://doi.org/10.3390/molecules27031031CrossRefPubMedPubMedCentral

Chen H, Liu S, Liu X, Yang J, Wang F, Cong X, Chen X (2017) Lysophosphatidic acid pretreatment attenuates myocardial ischemia/reperfusion injury in the immature hearts of rats. Front Physiol 8:153. https://doi.org/10.3389/fphys.2017.00153CrossRefPubMedPubMedCentral

10.

Chen X, Yang XY, Wang ND, Ding C, Yang YJ, You ZJ, Su Q, Chen JH (2003) Serum lysophosphatidic acid concentrations measured by dot immunogold filtration assay in patients with acute myocardial infarction. Scand J Clin Lab Invest 63:497–503. https://doi.org/10.1080/00365510310003265CrossRefPubMed

11.

Cheng XY, Chen C, He SF, Huang CX, Zhang L, Chen ZW, Zhang Y (2019) Spinal NGF induces anti-intrathecal opioid-initiated cardioprotective effect via regulation of TRPV1 expression. Eur J Pharmacol 844:145–155. https://doi.org/10.1016/j.ejphar.2018.12.007CrossRefPubMed

12.

Communal C, Singh K, Pimentel DR, Colucci WS (1998) Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway. Circulation 98:1329–1334. https://doi.org/10.1161/01.cir.98.13.1329CrossRefPubMed

13.

Dohi T, Miyauchi K, Ohkawa R, Nakamura K, Kurano M, Kishimoto T, Yanagisawa N, Ogita M, Miyazaki T, Nishino A, Yaginuma K, Tamura H, Kojima T, Yokoyama K, Kurata T, Shimada K, Daida H, Yatomi Y (2013) Increased lysophosphatidic acid levels in culprit coronary arteries of patients with acute coronary syndrome. Atherosclerosis 229:192–197. https://doi.org/10.1016/j.atherosclerosis.2013.03.038CrossRefPubMed

14.

Dou M, Ma Z, Cheng X, Zou G, Xu Y, Huang C, Xiong W, He S, Zhang Y (2019) Intrathecal lentivirus-mediated RNA interference targeting nerve growth factor attenuates myocardial ischaemia-reperfusion injury in rat. Br J Anaesth 123:439–449. https://doi.org/10.1016/j.bja.2019.06.024CrossRefPubMed

15.

Dull MM, Stengel M, Ries V, Strupf M, Reeh PW, Kremer AE, Namer B (2022) Lysophosphatidic acid activates nociceptors and causes pain or itch depending on the application mode in human skin. Pain 163:445–460. https://doi.org/10.1097/j.pain.0000000000002363CrossRefPubMed

16.

Eichholtz T, Jalink K, Fahrenfort I, Moolenaar WH (1993) The bioactive phospholipid lysophosphatidic acid is released from activated platelets. Biochem J 291(Pt 3):677–680. https://doi.org/10.1042/bj2910677CrossRefPubMedPubMedCentral

17.

Eisenhofer G, Friberg P, Rundqvist B, Quyyumi AA, Lambert G, Kaye DM, Kopin IJ, Goldstein DS, Esler MD (1996) Cardiac sympathetic nerve function in congestive heart failure. Circulation 93:1667–1676. https://doi.org/10.1161/01.cir.93.9.1667CrossRefPubMed

18.

Foreman RD, Garrett KM, Blair RW (2015) Mechanisms of cardiac pain. Compr Physiol 5:929–960. https://doi.org/10.1002/cphy.c140032CrossRefPubMed

19.

Gao Y, Song J, Chen H, Cao C, Lee C (2015) TRPV1 activation is involved in the cardioprotection of remote limb ischemic postconditioning in ischemia-reperfusion injury rats. Biochem Biophys Res Commun 463:1034–1039. https://doi.org/10.1016/j.bbrc.2015.06.054CrossRefPubMed

20.

Hausenloy DJ, Botker HE, Ferdinandy P, Heusch G, Ng GA, Redington A, Garcia-Dorado D (2019) Cardiac innervation in acute myocardial ischaemia/reperfusion injury and cardioprotection. Cardiovasc Res 115:1167–1177. https://doi.org/10.1093/cvr/cvz053CrossRefPubMedPubMedCentral

21.

Hausenloy DJ, Yellon DM (2007) Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection. Heart Fail Rev 12:217–234. https://doi.org/10.1007/s10741-007-9026-1CrossRefPubMed

22.

Hayakawa K, Kurano M, Ohya J, Oichi T, Kano K, Nishikawa M, Uranbileg B, Kuwajima K, Sumitani M, Tanaka S, Aoki J, Yatomi Y, Chikuda H (2019) Lysophosphatidic acids and their substrate lysophospholipids in cerebrospinal fluid as objective biomarkers for evaluating the severity of lumbar spinal stenosis. Sci Rep 9:9144. https://doi.org/10.1038/s41598-019-45742-7CrossRefPubMedPubMedCentral

23.

He S, Zambelli VO, Sinharoy P, Brabenec L, Bian Y, Rwere F, Hell RC, Stein Neto B, Hung B, Yu X, Zhao M, Luo Z, Wu C, Xu L, Svensson KJ, McAllister SL, Stary CM, Wagner NM, Zhang Y, Gross ER (2023) A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents. J Clin Invest 133:e163735. https://doi.org/10.1172/JCI163735CrossRefPubMedPubMedCentral

24.

Hernandez-Resendiz S, Prakash A, Loo SJ, Semenzato M, Chinda K, Crespo-Avilan GE, Dam LC, Lu S, Scorrano L, Hausenloy DJ (2023) Targeting mitochondrial shape: at the heart of cardioprotection. Basic Res Cardiol 118:49. https://doi.org/10.1007/s00395-023-01019-9CrossRefPubMedPubMedCentral

25.

Heusch G (2015) Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning. Circ Res 116:674–699. https://doi.org/10.1161/CIRCRESAHA.116.305348CrossRefPubMed

26.

Heusch G (2017) Vagal cardioprotection in reperfused acute myocardial infarction. JACC Cardiovasc Interv 10:1521–1522. https://doi.org/10.1016/j.jcin.2017.05.063CrossRefPubMed

27.

Heusch G (2020) Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol 17:773–789. https://doi.org/10.1038/s41569-020-0403-yCrossRefPubMed

28.

Howard-Quijano K, Yamaguchi T, Gao F, Kuwabara Y, Puig S, Lundquist E, Salavatian S, Taylor B, Mahajan A (2021) Spinal cord stimulation reduces ventricular arrhythmias by attenuating reactive gliosis and activation of spinal interneurons. JACC Clin Electrophysiol 7:1211–1225. https://doi.org/10.1016/j.jacep.2021.05.016CrossRefPubMedPubMedCentral

29.

Jiang D, Ju W, Wu X, Zhan X (2018) Elevated lysophosphatidic acid levels in the serum and cerebrospinal fluid in patients with multiple sclerosis: therapeutic response and clinical implication. Neurol Res 40:335–339. https://doi.org/10.1080/01616412.2018.1446256CrossRefPubMed

30.

Juarez-Contreras R, Rosenbaum T, Morales-Lazaro SL (2018) Lysophosphatidic acid and ion channels as molecular mediators of pain. Front Mol Neurosci 11:462. https://doi.org/10.3389/fnmol.2018.00462CrossRefPubMedPubMedCentral

31.

Kleinbongard P (2023) Perspective: mitochondrial STAT3 in cardioprotection. Basic Res Cardiol 118:32. https://doi.org/10.1007/s00395-023-01003-3CrossRefPubMedPubMedCentral

32.

Kleinbongard P, Skyschally A, Heusch G (2017) Cardioprotection by remote ischemic conditioning and its signal transduction. Pflug Arch Eur J Phy 469:159–181. https://doi.org/10.1007/s00424-016-1922-6CrossRef

33.

Lee JW, Lee CS, Ryu YR, Lee J, Son H, Cho HJ, Kim HS (2021) Lysophosphatidic acid receptor 4 is transiently expressed during cardiac differentiation and critical for repair of the damaged heart. Mol Ther 29:1151–1163. https://doi.org/10.1016/j.ymthe.2020.11.004CrossRefPubMed

34.

Lee JW, Lee CS, Son H, Lee J, Kang M, Chai J, Cho HJ, Kim HS (2023) SOX17-mediated LPAR4 expression plays a pivotal role in cardiac development and regeneration after myocardial infarction. Exp Mol Med 55:1424–1436. https://doi.org/10.1038/s12276-023-01025-wCrossRefPubMedPubMedCentral

35.

Liao M, Cao E, Julius D, Cheng Y (2013) Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature 504:107–112. https://doi.org/10.1038/nature12822CrossRefPubMedPubMedCentral

36.

Lieder HR, Kleinbongard P, Skyschally A, Hagelschuer H, Chilian WM, Heusch G (2018) Vago-splenic axis in signal transduction of remote ischemic preconditioning in pigs and rats. Circ Res 123:1152–1163. https://doi.org/10.1161/CIRCRESAHA.118.313859CrossRefPubMedPubMedCentral

37.

Longhurst JC, Tjen ALSC, Fu LW (2001) Cardiac sympathetic afferent activation provoked by myocardial ischemia and reperfusion. Mechanisms and reflexes. Ann N Y Acad Sci 940:74–95. https://doi.org/10.1111/j.1749-6632.2001.tb03668.xCrossRefPubMed

38.

Morales-Lazaro SL, Rosenbaum T (2015) A painful link between the TRPV1 channel and lysophosphatidic acid. Life Sci 125:15–24. https://doi.org/10.1016/j.lfs.2014.10.004CrossRefPubMed

39.

Morales-Lazaro SL, Serrano-Flores B, Llorente I, Hernandez-Garcia E, Gonzalez-Ramirez R, Banerjee S, Miller D, Gududuru V, Fells J, Norman D, Tigyi G, Escalante-Alcalde D, Rosenbaum T (2014) Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs. J Biol Chem 289:24079–24090. https://doi.org/10.1074/jbc.M114.572503CrossRefPubMedPubMedCentral

40.

Munjuluri S, Wilkerson DA, Sooch G, Chen X, White FA, Obukhov AG (2021) Capsaicin and TRPV1 channels in the cardiovascular system: the role of inflammation. Cells. https://doi.org/10.3390/cells11010018CrossRefPubMedPubMedCentral

41.

Nieto-Posadas A, Picazo-Juarez G, Llorente I, Jara-Oseguera A, Morales-Lazaro S, Escalante-Alcalde D, Islas LD, Rosenbaum T (2011) Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site. Nat Chem Biol 8:78–85. https://doi.org/10.1038/nchembio.712CrossRefPubMed

42.

Oude Elferink RP, Bolier R, Beuers UH (2015) Lysophosphatidic acid and signaling in sensory neurons. Biochim Biophys Acta 1851:61–65. https://doi.org/10.1016/j.bbalip.2014.09.004CrossRefPubMed

43.

Pages C, Simon MF, Valet P, Saulnier-Blache JS (2001) Lysophosphatidic acid synthesis and release. Prostag Oth Lipid M 64:1–10. https://doi.org/10.1016/s0090-6980(01)00110-1CrossRef

44.

Pan HL, Chen SR (2004) Sensing tissue ischemia: another new function for capsaicin receptors? Circulation 110:1826–1831. https://doi.org/10.1161/01.CIR.0000142618.20278.7ACrossRefPubMed

45.

Pei J, Cai L, Wang F, Xu C, Pei S, Guo H, Sun X, Chun J, Cong X, Zhu W, Zheng Z, Chen X (2022) LPA(2) contributes to vascular endothelium homeostasis and cardiac remodeling after myocardial infarction. Circ Res 131:388–403. https://doi.org/10.1161/CIRCRESAHA.122.321036CrossRefPubMed

46.

Poon YY, Chang AY, Ko SF, Chan SH (2011) Catheterization of the thoracic spinal subarachnoid space in mice. J Neurosci Methods 200:36–40. https://doi.org/10.1016/j.jneumeth.2011.06.010CrossRefPubMed

47.

Randhawa PK, Jaggi AS (2017) TRPV1 channels in cardiovascular system: a double edged sword? Int J Cardiol 228:103–113. https://doi.org/10.1016/j.ijcard.2016.11.205CrossRefPubMed

48.

Randhawa PK, Jaggi AS (2018) A review on potential involvement of TRPV(1) channels in ischemia-reperfusion injury. J Cardiovasc Pharmacol Ther 23:38–45. https://doi.org/10.1177/1074248417707050CrossRefPubMed

49.

Robertson S, Thomson AL, Carter R, Stott HR, Shaw CA, Hadoke PW, Newby DE, Miller MR, Gray GA (2014) Pulmonary diesel particulate increases susceptibility to myocardial ischemia/reperfusion injury via activation of sensory TRPV1 and beta1 adrenoreceptors. Part Fibre Toxicol 11:12. https://doi.org/10.1186/1743-8977-11-12CrossRefPubMedPubMedCentral

50.

Sogut O, Kaya H, Gokdemir MT, Sezen Y (2012) Acute myocardial infarction and coronary vasospasm associated with the ingestion of cayenne pepper pills in a 25-year-old male. Int J Emerg Med 5:5. https://doi.org/10.1186/1865-1380-5-5CrossRefPubMedPubMedCentral

51.

Tawa M, Yamamoto S, Ohkita M, Matsumura Y (2012) Endothelin-1 and norepinephrine overflow from cardiac sympathetic nerve endings in myocardial ischemia. Cardiol Res Pract 2012:789071. https://doi.org/10.1155/2012/789071CrossRefPubMedPubMedCentral

52.

Tigyi G (2011) Lipids: LPA activates TRPV1–and it hurts. Nat Chem Biol 8:22–23. https://doi.org/10.1038/nchembio.738CrossRefPubMedPubMedCentral

53.

Tripathi H, Al-Darraji A, Abo-Aly M, Peng H, Shokri E, Chelvarajan L, Renee RD, Levitan BM, Gao E, Hernandez G, Morris AJ, Smyth SS, Abdel-Latif A (2020) Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction. J Mol Cell Cardiol 149:95–114. https://doi.org/10.1016/j.yjmcc.2020.09.011CrossRefPubMedPubMedCentral

54.

Uranbileg B, Ito N, Kurano M, Saigusa D, Saito R, Uruno A, Kano K, Ikeda H, Yamada Y, Sumitani M, Sekiguchi M, Aoki J, Yatomi Y (2019) Alteration of the lysophosphatidic acid and its precursor lysophosphatidylcholine levels in spinal cord stenosis: a study using a rat cauda equina compression model. Sci Rep 9:16578. https://doi.org/10.1038/s41598-019-52999-5CrossRefPubMedPubMedCentral

55.

Wang L, Wang DH (2005) TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice. Circulation 112:3617–3623. https://doi.org/10.1161/CIRCULATIONAHA.105.556274CrossRefPubMed

56.

Wu C, Liu R, Luo Z, Sun M, Qile M, Xu S, Jin S, Zhang L, Gross ER, Zhang Y, He S (2022) Spinal cord astrocytes regulate myocardial ischemia-reperfusion injury. Basic Res Cardiol 117:56. https://doi.org/10.1007/s00395-022-00968-xCrossRefPubMedPubMedCentral

57.

Xu S, Xu Y, Cheng X, Huang C, Pan Y, Jin S, Xiong W, Zhang L, He S, Zhang Y (2020) Inhibition of DRG-TRPV1 upregulation in myocardial ischemia contributes to exogenous cardioprotection. J Mol Cell Cardiol 138:175–184. https://doi.org/10.1016/j.yjmcc.2019.12.003CrossRefPubMed

58.

Yang C, Yamaki S, Jung T, Kim B, Huyhn R, McKemy DD (2023) Endogenous inflammatory mediators produced by injury activate TRPV1 and TRPA1 nociceptors to induce sexually dimorphic cold pain that is dependent on TRPM8 and GFRalpha3. J Neurosci 43:2803–2814. https://doi.org/10.1523/JNEUROSCI.2303-22.2023CrossRefPubMedPubMedCentral

59.

Yang J, Xu J, Han X, Wang H, Zhang Y, Dong J, Deng Y, Wang J (2018) Lysophosphatidic acid is associated with cardiac dysfunction and hypertrophy by suppressing autophagy via the LPA3/AKT/mTOR pathway. Front Physiol 9:1315. https://doi.org/10.3389/fphys.2018.01315CrossRefPubMedPubMedCentral

60.

Yellon DM, Beikoghli Kalkhoran S, Davidson SM (2023) The RISK pathway leading to mitochondria and cardioprotection: how everything started. Basic Res Cardiol 118:22. https://doi.org/10.1007/s00395-023-00992-5CrossRefPubMedPubMedCentral

61.

Zahner MR, Li DP, Chen SR, Pan HL (2003) Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats. J Physiol 551:515–523. https://doi.org/10.1113/jphysiol.2003.048207CrossRefPubMedPubMedCentral

62.

Zhang D, Zhang Y, Zhao C, Zhang W, Shao G, Zhang H (2016) Effect of lysophosphatidic acid on the immune inflammatory response and the connexin 43 protein in myocardial infarction. Exp Ther Med 11:1617–1624. https://doi.org/10.3892/etm.2016.3132CrossRefPubMedPubMedCentral

63.

Zhao Y, Hasse S, Zhao C, Bourgoin SG (2019) Targeting the autotaxin—lysophosphatidic acid receptor axis in cardiovascular diseases. Biochem Pharmacol 164:74–81. https://doi.org/10.1016/j.bcp.2019.03.035CrossRefPubMed

64.

Zhong B, Wang DH (2007) TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice. Am J Physiol Heart Circ Physiol 293:H1791–H1798. https://doi.org/10.1152/ajpheart.00169.2007CrossRefPubMed

65.

Zhou Y, Little PJ, Ta HT, Xu S, Kamato D (2019) Lysophosphatidic acid and its receptors: pharmacology and therapeutic potential in atherosclerosis and vascular disease. Pharmacol Ther 204:107404. https://doi.org/10.1016/j.pharmthera.2019.107404CrossRefPubMed

Title: Lysophosphatidic acid contributes to myocardial ischemia/reperfusion injury by activating TRPV1 in spinal cord
Authors: Chao Wu
Meiyan Sun
Muge Qile
Yu Zhang
Liu Liu
Xueying Cheng
Xiaoxiao Dai
Eric R. Gross
Ye Zhang
Shufang He
Publication date: 18-01-2024
Publisher: Springer Berlin Heidelberg
Published in: Basic Research in Cardiology / Issue 2/2024
Print ISSN: 0300-8428
Electronic ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-023-01031-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Lysophosphatidic acid contributes to myocardial ischemia/reperfusion injury by activating TRPV1 in spinal cord

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2024

The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics

Crosstalk of human coronary perivascular adipose-derived stem cells with vascular cells: role of tissue factor

Mineralocorticoid receptor promotes cardiac macrophage inflammaging

Role of CD4+ T-cells for regulating splenic myelopoiesis and monocyte differentiation after experimental myocardial infarction

Pathophysiology and clinical relevance of atrial myopathy

Distinct cytoskeletal regulators of mechanical memory in cardiac fibroblasts and cardiomyocytes