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01-01-2012 | Case Report

Lymphomatosis cerebri: clinical characteristics, neuroimaging, and pathological findings

Authors: Ryuhei Kitai, Norichika Hashimoto, Kouji Yamate, Masamichi Ikawa, Makoto Yoneda, Tsuyoshi Nakajima, Hidetaka Arishima, Hiroaki Takeuchi, Kazufumi Sato, Ken-Ichiro Kikuta

Published in: Brain Tumor Pathology | Issue 1/2012

Abstract

Lymphomatosis cerebri is a rare variant of primary central nervous system lymphoma. We present a case involving a 56-year-old immunocompetent woman who complained of rapid deterioration of her higher brain function over a 4-month period. Magnetic resonance imaging showed extensive white-matter lesions. During brain biopsy, a diffusely infiltrating lymphoma with distinctive immunohistochemical features was detected. Awareness of this unique presentation and early tissue diagnosis provide the best hope for instituting appropriate treatments.

Louis DN, Ohgaki H, Wiestler OD et al (2007) Malignant lymphomas. WHO Classification of Tumours of the Central Nervous System, 4th edn. IARC, Lyon, pp 188–192

Pandit L, Chickabasaviah Y, Raghothaman A et al (2010) Lymphomatosis cerebri—a rare cause of leukoencephalopathy. J Neurol Sci 293:122–124PubMedCrossRef

Raz E, Tinelli E, Antonelli M et al (2011) MRI findings in lymphomatosis cerebri: description of a case and revision of the literature. J Neuroimaging 21:183–186CrossRef

Lewerenz J, Ding X, Matschke J et al (2007) Dementia and leukoencephalopathy due to lymphomatosis cerebri. J Neurol Neurosurg Psychiatry 78:777–778PubMedCrossRef

Rollins KE, Kleinschmidt-DeMasters BK, Corboy JR et al (2005) Lymphomatosis cerebri as a cause of white matter dementia. Hum Pathol 36(3):282–290

Weaver JD, Vinters HV, Koretz B et al (2007) Lymphomatosis cerebri presenting as rapidly progressive dementia. Neurologist 13:150–153PubMedCrossRef

Leschziner G, Rudge P, Lucas S et al. (2011) Lymphomatosis cerebri presenting as a rapidly progressive dementia with a high methylmalonic acid. J Neurol (Epub ahead of print)

Furusawa T, Okamoto K, Ito J et al (1998) Primary central nervous system lymphoma presenting as diffuse cerebral infiltration. Radiat Med 16:137–140PubMed

Bakshi R, Mazziotta JC, Mischel PS et al (1999) Lymphomatosis cerebri presenting as a rapidly progressive dementia: clinical, neuroimaging and pathologic findings. Dement Geriatr Cogn Disord 10:152–157PubMedCrossRef

10.

Sugie M, Ishihara K, Kato H et al (2009) Primary central nervous system lymphoma initially mimicking lymphomatosis cerebri: an autopsy case report. Neuropathology 29:704–707PubMedCrossRef

11.

Kanai R, Shibuya M, Hata T et al (2008) A case of ‘lymphomatosis cerebri’ diagnosed in an early phase and treated by whole brain radiation: case report and literature review. J Neurooncol 86:83–86PubMedCrossRef

12.

Vital A, Sibon I (2007) A 64-year-old woman with progressive dementia and leukoencephalopathy. Brain Pathol 17:117–118PubMedCrossRef

13.

de Toledo M, López-Valdés E, Ferreiro M et al (2008) Lymphomatosis cerebri as the cause of leukoencephalopathy. Rev Neurol 46:667–670PubMed

14.

Hishikawa N, Niwa H, Hara T et al. (2011) An autopsy case of lymphomatosis cerebri showing pathological changes of intravascular large B-cell lymphoma in visceral organs. Neuropathology (Epub ahead of print)

Title: Lymphomatosis cerebri: clinical characteristics, neuroimaging, and pathological findings
Authors: Ryuhei Kitai
Norichika Hashimoto
Kouji Yamate
Masamichi Ikawa
Makoto Yoneda
Tsuyoshi Nakajima
Hidetaka Arishima
Hiroaki Takeuchi
Kazufumi Sato
Ken-Ichiro Kikuta
Publication date: 01-01-2012
Publisher: Springer Japan
Published in: Brain Tumor Pathology / Issue 1/2012
Print ISSN: 1433-7398
Electronic ISSN: 1861-387X
DOI: https://doi.org/10.1007/s10014-011-0064-y

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Lymphomatosis cerebri: clinical characteristics, neuroimaging, and pathological findings

Abstract

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Abstract

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