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Child's Nervous System

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04-07-2023 | Lymphoma | Case-based Review

Study on primary central nervous system lymphoma in pediatric patients

Authors: Xiang Li, Jian Gong

Published in: Child's Nervous System | Issue 8/2023

Abstract

Background

Primary central nervous system lymphoma (PCNSL) in pediatric patients presents diagnostic and treatment challenges, leading to delays and suboptimal strategies. Moreover, PCNSL in immunocompetent pediatric patients is rarely reported. This retrospective study aimed to describe the demographic and clinical features, as well as outcomes, of pediatric PCNSL cases.

Methods

A retrospective review was conducted on 11 immunocompetent pediatric patients diagnosed with PCNSL between January 2012 and April 2020. Data regarding age, gender, initial presenting symptoms, tumor location, and radiological characteristics were collected. Treatment strategies and analyzed prognosis were documented. Survival curves were generated using the Kaplan-Meir method, and data were analyzed using SPSS (version 23.0, IBM Corp.).

Results

The study cohort comprised 11 patients, including 10 males and 1 female. The age at diagnosis ranged from 4 to 15 years, with a median age of 10.6 years. Headache was the most common presenting symptom, observed in 81.8% (9/11) of patients. Tumor locations in the supratentorial and infratentorial regions exhibited a similar occurrence rate. All tumors showed strong contrast enhancement on T1-weighted images. The average survival time for the 11 patients was 44.4 months. Among them, 5 patients died by the last follow-up visit, with a mean survival time of 8.8 months (one patient died in a car accident).

Conclusion

Headache is the predominant manifestation of PCNSL in pediatric patients. PCNSL demonstrates imaging characteristics resembling various intracranial tumors and is associated with a poor prognosis. Therefore, pediatric neurosurgeons should exercise caution in diagnosing and treating intracranial lymphoma.

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Title: Study on primary central nervous system lymphoma in pediatric patients
Authors: Xiang Li
Jian Gong
Publication date: 04-07-2023
Publisher: Springer Berlin Heidelberg
Keywords: Lymphoma
Headache
Hydrocephalus
Hydrocephalus
Hydrocephalus
Published in: Child's Nervous System / Issue 8/2023
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-023-06021-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Study on primary central nervous system lymphoma in pediatric patients

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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