Published in:
01-11-2020 | Lymphoma | Case Report
HHV8-positive, EBV-positive Hodgkin lymphoma-like large B cell lymphoma: expanding the spectrum of HHV8 and EBV-associated lymphoproliferative disorders
Authors:
Sandra Sanchez, Luis Veloza, Luojun Wang, Mónica López, Armando López-Guillermo, Marta Marginet, Antonio Martínez, Olga Balagué, Elias Campo
Published in:
International Journal of Hematology
|
Issue 5/2020
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Abstract
Human herpesvirus type 8 (HHV8) is a gamma herpesvirus known for its role in lymphoid neoplasms, especially in immunosuppressed patients. We describe the case of a 64-year-old male, without known immunodeficiency, with 1-year-long clinical history of mediastinal and abdominal lymphadenopathies and recurrent pulmonary infections. Histopathological evaluation of a mediastinal lymph node revealed the presence of scattered atypical large cells with Hodgkin and Reed–Sternberg morphology in a background of lymphocytes and extensive areas of fibrosis. The large cells were positive for HHV8 and Epstein–Barr virus (EBV), with a clonal pattern of IGH gene rearrangement. A descriptive diagnosis of “HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma” was rendered. Interestingly, the retrospective evaluation of a previous biopsy, diagnosed as reactive lymphadenitis, revealed the presence of HHV8- and EBV-positive cells, with a polyclonal pattern and a small peak corresponding to that of the most recent biopsy. This case presents diagnostic challenges due to the presence of particular features not clearly related to current HHV8-associated entities, and also suggests the possibility for disease progression in the spectrum of HHV8- and EBV-associated lymphoproliferative disorders.