Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ASCO Annual Meeting 2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

2024 ASCO Annual Meeting

Keep up to date with all the top stories and latest evidence with our hub page, including official congress videos and expert takeaways.
ADVANCED SEARCH
Log in
Top
Indian Journal of Surgical Oncology
Published in: Indian Journal of Surgical Oncology 1/2024

05-01-2024 | Lymphoma | Case Report

A Case of Medullary Carcinoma of Colon Morphologically Resembling Non-Hodgkin’s Lymphoma

Authors: Md Ali Osama, Shashi Dhawan, Arvind Kumar

Published in: Indian Journal of Surgical Oncology | Issue 1/2024

Login to get access

Abstract

Medullary carcinoma of the colon is an unusual and unique histologic subtype of colorectal cancer. It is strongly associated with microsatellite instability, most commonly loss of MLH1 indicative of deficient mismatch repair proteins. Diagnosis is challenging as they do not display the usual histological pattern. Immunohistochemical staining also shows unusual findings like negativity for CD20 and CDX2. Here, we explore an intriguing case of medullary carcinoma of colon which showed loss of MSH2 and MSH6 and a morphology reminiscent of Non-Hodgkin’s lymphoma.
Literature
1.
Pyo JS, Sohn JH, Kang G (2016) Medullary carcinoma in the colorectum: a systematic review and meta-analysis. Hum Pathol 53:91–96CrossRefPubMed
2.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, An J (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424CrossRefPubMed
3.
Thirunavukarasu P, Sathaiah M, Singla S, Sukumar S, Karunamurthy A, Pragatheeshwar KD, Lee KK, Zeh H 3rd, Kane KM, Bartlett DL (2010) Medullary carcinoma of the large intestine: a population based analysis. Int J Oncol 37:901–907PubMed
4.
Koopman M, Kortman GA, Mekenkamp L, Ligtenberg MJ, Hoogerbrugge N, Antonini NF, Punt CJ, van Krieken JH (2009) Deficient mismatch repair system in patients with sporadic advanced colorectal cancer. Br J Cancer 100:266–273CrossRefPubMedPubMedCentral
5.
Gómez-Álvarez MA, Lino-Silva LS, Salcedo-Hernández RA, Padilla-Rosciano A, Ruiz-García EB, López-Basave HN, Calderillo-Ruiz G, Aguilar-Romero JM, Domínguez-Rodríguez JA, Herrera-Gómez Á, Meneses-García A (2017) Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability. Prz Gastroenterol 12:208–214PubMed
6.
Martinotti M, Cirillo F, Ungari M, Tanzi G, Rolando G, Tarasconi A, Ranieri V, Aulisa P, Vismarra M, Rovatti M, Trombatore M (2017) Microsatellite instability in medullary carcinoma of the Colon. Rare Tumors 9:6541CrossRefPubMedPubMedCentral
7.
Lin F, Shi J, Zhu S, Chen Z, Li A, Chen T, Wang HL, Liu H (2014) Cadherin-17 and SATB2 are sensitive and specific immunomarkers for medullary carcinoma of the large intestine. Arch Pathol Lab Med 138:1015–1026CrossRefPubMed
8.
Friedman K, Brodsky AS, Lu S, Wood S, Gill AJ, Lombardo K, Yang D, Resnick MB (2016) Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment. Mod Pathol 29:528–541CrossRefPubMed
9.
Jain S, Jain A, Onizuka N, Boukhar SA (2014) A rare case of medullary carcinoma of the colon presenting as intussusception in an adult with rectal bleeding. Hawaii J Med Public Health 73:348–352PubMedPubMedCentral
Metadata
Title
A Case of Medullary Carcinoma of Colon Morphologically Resembling Non-Hodgkin’s Lymphoma
Authors
Md Ali Osama
Shashi Dhawan
Arvind Kumar
Publication date
05-01-2024
Publisher
Springer India
Published in
Indian Journal of Surgical Oncology / Issue 1/2024
Print ISSN: 0975-7651
Electronic ISSN: 0976-6952
DOI
https://doi.org/10.1007/s13193-023-01872-z

Other articles of this Issue 1/2024

Indian Journal of Surgical Oncology 1/2024 Go to the issue

Original Article

Ghost Stoma Solving the Dilemma of Diversion After Anterior Resection: Surgical Technique Description and Experience from a Single Centre

Case Report

Rapid On-site Evaluation (ROSE) Cytology of Mucoepidermoid Carcinoma and its Diagnostic Pitfalls: a Case Report

Point of Technique

Approach Toward Oncoplastic Breast Surgery: Local (Flap) Solutions for Indian Problems

Letter to the Editor

Comment on “From ChatGPT to Treatment: the Future of AI and Large Language Models in Surgical Oncology”

Original Article

Expression Profile of KRAS and p16 in Periampullary Cancer

Case Report

Intrapulmonary Ancient Schwannoma: a Rare Tumour