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01-02-2012 | Original

Lung strain and biological response in mechanically ventilated patients

Authors: Adrián González-López, Emilio García-Prieto, Estefanía Batalla-Solís, Laura Amado-Rodríguez, Noelia Avello, Lluís Blanch, Guillermo M. Albaiceta

Published in: Intensive Care Medicine | Issue 2/2012

Abstract

Purpose

Lung tissue may exhibit a biochemical response to excessive deformation. Since strain has been proposed as a marker of such deformation, we studied the relationships between strain and matrix remodeling and inflammation markers in mechanically ventilated patients with and without acute lung injury (ALI).

Methods

Twenty-two ventilated patients were studied (16 with ALI, 6 controls). Clinical data, gas exchange and respiratory mechanics were recorded, and end-expiratory lung volume (EELV) was measured by oxygen washin/washout. Extracellular matrix remodeling markers (procollagen, matrix metalloproteinases -2 and -9, TIMP-1) and inflammation markers (IL-6, IL-8, IL-10, IFNγ, IL-17A, and VEGF) were measured in bronchoalveolar lavage fluid (BALF). Strain was computed as the ratio between tidal volume and EELV. Patients with ALI were divided into two subgroups according to the median strain value (0.27).

Results

Patients in the ALI group exhibited higher airway pressures, lower EELV and higher strain than the control group. There were no significant differences in gas exchange, respiratory mechanics, or the matrix remodeling markers between ALI patients with normal and high strain. The subgroup of patients with high strain showed a fourfold increase of IL-6 and IL-8 concentrations in BALF, compared with patients with ALI and normal strain or patients without ALI. In the whole sample, IL-6 and IL-8 concentrations in BALF were correlated with strain (Spearman’s ρ = 0.67 and 0.77, respectively).

Conclusions

Increased strain is associated with a proinflammatory lung response in patients with ALI.

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Title: Lung strain and biological response in mechanically ventilated patients
Authors: Adrián González-López
Emilio García-Prieto
Estefanía Batalla-Solís
Laura Amado-Rodríguez
Noelia Avello
Lluís Blanch
Guillermo M. Albaiceta
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 2/2012
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-011-2403-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Lung strain and biological response in mechanically ventilated patients

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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