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European Radiology
Published in: European Radiology 8/2010

Open Access 01-08-2010 | Computed Tomography

Lung nodule volumetry: segmentation algorithms within the same software package cannot be used interchangeably

Authors: H. Ashraf, B. de Hoop, S. B. Shaker, A. Dirksen, K. S. Bach, H. Hansen, M. Prokop, J. H. Pedersen

Published in: European Radiology | Issue 8/2010

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Abstract

Objective

We examined the reproducibility of lung nodule volumetry software that offers three different volumetry algorithms.

Methods

In a lung cancer screening trial, 188 baseline nodules >5 mm were identified. Including follow-ups, these nodules formed a study-set of 545 nodules. Nodules were independently double read by two readers using commercially available volumetry software. The software offers readers three different analysing algorithms. We compared the inter-observer variability of nodule volumetry when the readers used the same and different algorithms.

Results

Both readers were able to correctly segment and measure 72% of nodules. In 80% of these cases, the readers chose the same algorithm. When readers used the same algorithm, exactly the same volume was measured in 50% of readings and a difference of >25% was observed in 4%. When the readers used different algorithms, 83% of measurements showed a difference of >25%.

Conclusion

Modern volumetric software failed to correctly segment a high number of screen detected nodules. While choosing a different algorithm can yield better segmentation of a lung nodule, reproducibility of volumetric measurements deteriorates substantially when different algorithms were used. It is crucial even in the same software package to choose identical parameters for follow-up.
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Metadata
Title
Lung nodule volumetry: segmentation algorithms within the same software package cannot be used interchangeably
Authors
H. Ashraf
B. de Hoop
S. B. Shaker
A. Dirksen
K. S. Bach
H. Hansen
M. Prokop
J. H. Pedersen
Publication date
01-08-2010
Publisher
Springer-Verlag
Published in
European Radiology / Issue 8/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-010-1749-z

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