Top

International Archives of Occupational and Environmental Health

Published in:

01-11-2012 | Original Article

Lung function decline and blood lead among residents nearby to industrial complex

Authors: Yun-Suk Pak, Aeri Oh, Young Lim Kho, Domyung Paek

Published in: International Archives of Occupational and Environmental Health | Issue 8/2012

Abstract

Purpose

This study was to ascertain the risk factors of pulmonary function decline (forced expiratory volume in 1 s [FEV₁], forced vital capacity [FVC]) among those exposed to lead in the vicinity of industrial complex.

Methods

In total, 263 men and women, aged over 30, were recruited from two cities during a 2-year follow-up. Spirometry testing was conducted first at baseline and then after 2-years of follow-up. The change in FVC and FEV₁ during the study period was analyzed according to blood lead (BPb), urinary cotinine, and 1-hydroxypyrene, after controlling for sex, height, baseline FVC or FEV₁, and airway hyperresponsiveness.

Results

With increase in age, both FEV₁ and FVC declined. More marked decline in FVC was noted for men than for women (p < 0.05), while the decline in FEV₁ was not. Biological variables, especially height (p < 0.05) and pulmonary status (p < 0.0001), were associated with the decline in both FEV₁ and FVC. Even after controlling these other variables, blood lead level was also significantly associated with the decline of FVC.

Conclusions

Even though the decline in FEV₁ and FVC with aging was within a normal range, people with smaller height were more vulnerable to the decline of both FEV₁ and FVC and especially higher level of BPb was accompanied with larger decline of FVC. Oxidative stress in relation to lead accumulation in adult may contribute to rapid aging of pulmonary function.

Baek SO (2007) The study of Hazardous air pollutants (HAPs) in Shiwha-Banwol. Ministry of Environment, Republic of Korea. http://www.me.go.kr. Accessed 22 Dec 2010

Bagci C, Bozkurt AI, Cakmak EA, Can S, Cengiz B (2004) Blood lead levels of the battery and exhaust workers and their pulmonary function tests. Int J Clin Pract 58(6):568–572CrossRef

Bolin C, Basha R, Cox D, Zawia N, Maloney B, Lahiri D, Cardozo-Pelaez F (2006) Exposure to lead (Pb) and the developmental origin of oxidative DNA damage in the aging brain. FASEB J 20(6):788–790

Burrows B, Cline MG, Knudson RJ, Taussing LM, Lebowitx MD (1983) A descriptive analysis of the growth and decline of the FVC and FEV₁. Chest 83(5):717–724CrossRef

Cockcroft D, Killian D, Mellon J, Hargreave F (1977) Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Exp Allergy 7(3):235–243CrossRef

Cohn J, Donoso H (1963) Mechanical properties of lung in normal men over 60 years old. J Clin Invest 42(9):1406–1410CrossRef

Coultas D, Zumwalt R, Black W, Sobonya R (1994) The epidemiology of interstitial lung diseases. Am J Respir Crit Care Med 150(4):967–972

Dow L, Coggon D, Holgate S (1992) Respiratory symptoms as predictors of airways lability in an elderly population. Respir Med 86(1):27–32CrossRef

Ercal N, Neal R, Treeratphan P, Lutz P, Hammond T, Dennery P, Spitz D (2000) A role for oxidative stress in suppressing serum immunoglobulin levels in lead-exposed Fisher 344 rats. Arch Environ Contam Toxicol 39(2):251–256CrossRef

Fletcher C, Peto R, Tinker C, Speizer F (1976) The natural history of chronic bronchitis and emphysema. Oxford University Press, New York

Gallicchio L, Scherer RW, Sexton M (2002) Influence of nutrient intake on blood lead levels of young children at risk for lead poisoning. Environ Health Perspect 110(12):A767–A772CrossRef

Jongeneelen F, Anzion R, Henderson P (1987) Determination of hydroxylated metabolites of polycyclic aromatic hydrocarbons in urine. J Chromatogr A 413:227–232

Knudson RJ, Slatin RC, Lebowitz MD, Burrows B (1976) The maximal expiratory flow-volume curve: normal standards, variability, and effects of age. Am Rev Respir Dis 113(5):587–600

Law M, Tang JL (1995) An Analysis of the effectiveness of interventions intended to help people stop smoking. Arch Intern Med 155(18):1933–1941CrossRef

Lee D, Lim J, Song K, Boo Y, Jacobs D Jr (2006) Graded associations of blood lead and urinary cadmium concentrations with oxidative-stress-related markers in the US population: results from the third national health and nutrition examination survey. Environ Health Perspect 114(3):350–354CrossRef

Macklem P (1998) The physiology of small airways. Am J Respir 157(5):S181–S183

Marchetti C (2003) Molecular targets of lead in brain neurotoxicity. Neurotoxic Res 5(3):221–236CrossRef

Marston B, Plouffe J, File T Jr, Hackman B, Salstrom S, Lipman H, Kolczak M, Breiman R (1997) Incidence of community-acquired pneumonia requiring hospitalization: results of a population-based active surveillance study in Ohio. Arch Intern Med 157(15):1709–1718CrossRef

Mauel J, Ransijn A, Buchmuller-Rouiller Y (1989) Lead inhibits intracellular killing of Leishmania parasites and extracellular cytolysis of target cells by macrophages exposed to macrophage activating factor. J Leukoc Biol 45(5):401–409

Mazzon E, Cuzzocrea S (2007) Role of TNF-α in lung tight junction alteration in mouse model of acute lung inflammation. Respir Res 8(75):1–19

Menke A (2006) Blood Lead Below 0.48 μmol/L (10 μg/dl) and Mortality Among US Adults. Circulation 114(13):1388–1394CrossRef

Min JY, Min KB, Kim R, Cho SI, Paek D (2008) Blood lead levels and increased bronchial responsiveness. Biol Trace Elem Res 123(1–3):41–46CrossRef

Navas-Acien A, Guallar E, Silbergeld EK, Rothenberg SJ (2006) Lead exposure and cardiovascular disease—a systematic review. Environ Health Perspect 115(3):472–482CrossRef

Olivieri M, Verlato G, Corsico A, Lo Cascio V, Bugiani M, Marinoni A, de Marco R (2002) Prevalence and features of allergic rhinitis in Italy. Allergy 57(7):600–606CrossRef

Pauwels R, Buist A, Calverley P, Jenkins C, Hurd S (2001) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO global initiative for chronic obstructive lung disease (GOLD) workshop summary. Am J Respir Crit Care Med 163(5):1256–1276

Perlstein T, Weuve J, Schwartz J, Sparrow D, Wright R, Litonjua A, Nie H, Hu H (2007) Cumulative community-level lead exposure and pulse pressure: the normative aging study. Environ Health Perspect 115(12):1696–1700CrossRef

Pocock S, Shaper A, Ashby D, Delves H, Clayton B (1988) The relationship between blood lead, blood pressure, stroke, and heart attacks in middle-aged British men. Environ Health Perspect 78:23–30CrossRef

Schoenberg J, Beck G, Bouhuys A (1978) Growth and decay of pulmonary function in healthy blacks and whites. Respir Physiol 33(3):367–393CrossRef

Zelikoff J, Parsons E, Schlesinger R (1993) Inhalation of particulate lead oxide disrupts pulmonary macrophage-mediated functions important for host defense and tumor surveillance in the lung. Environ Res 62(2):207–222CrossRef

Zielińska-Danch W, Wardas W, Sobczak A, Szoltysek-boldys I (2007) Estimation of urinary cotinine cut-off points distinguishing non-smokers, passive and active smokers. Biomarkers 12(5):484–496CrossRef

Title: Lung function decline and blood lead among residents nearby to industrial complex
Authors: Yun-Suk Pak
Aeri Oh
Young Lim Kho
Domyung Paek
Publication date: 01-11-2012
Publisher: Springer-Verlag
Published in: International Archives of Occupational and Environmental Health / Issue 8/2012
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-012-0743-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Lung function decline and blood lead among residents nearby to industrial complex

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 8/2012

The negative impact of attention-deficit/hyperactivity disorder on occupational health in adults and adolescents

Absenteeism due to voice disorders in female teachers: a public health problem

Atypical work schedules are associated with poor sleep quality and mental health in Taiwan female nurses

Variation in benchmark dose (BMD) and the 95% lower confidence limit of benchmark dose (BMDL) among general Japanese populations with no anthropogenic exposure to cadmium

Measuring short-term and long-term physiological stress effects by cortisol reactivity in saliva and hair

Worrying exposure to trace elements in the population of Kinshasa, Democratic Republic of Congo (DRC)