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Journal of Cardiothoracic Surgery

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Open Access 01-12-2021 | Lung Cancer | Research article

Sugammadex is associated with shorter hospital length of stay after open lobectomy for lung cancer: a retrospective observational study

Authors: Seung Won Song, Kyung Yeon Yoo, Yong Sung Ro, Taehee Pyeon, Hong-Beom Bae, Joungmin Kim

Published in: Journal of Cardiothoracic Surgery | Issue 1/2021

Abstract

Background

Sugammadex is associated with few postoperative complications. Postoperative pulmonary complications (PPC) are related to prolonged hospitalizations. Present study explored whether the use of sugammadex could reduce PPCs and thereby reduce hospital length of stay (LOS) after lung surgery.

Methods

We reviewed the medical records of patients who underwent elective open lobectomy for lung cancer from January 2010 to December 2015. Patients were divided into the sugammadex group and pyridostigmine group.

The primary outcome was hospital LOS and secondary outcomes were postoperative complications and overall survival at 1 year. The cohort was subdivided into patients with and without prolonged LOS to explore the effects of sugammadex on outcomes in each group. Risk factors for LOS were determined via multivariate analyses. After propensity score matching, 127 patients were assigned to each group.

Results

Median hospital LOS was shorter (10.0 vs. 12.0 days) and the incidence of postoperative atelectasis was lower (18.1 vs. 29.9%) in the sugammadex group. However, no significant difference in overall survival between the groups was seen over 1 year (hazard ratio, 0.967; 95% confidence interval, 0.363 to 2.577). Sugammadex was a predictor related to LOS (exponential coefficient 0.88; 95% CI 0.82–0.95).

Conclusions

Our data suggest that sugammadex is a preferable agent for neuromuscular blockade (NMB) reversal than cholinesterase inhibitors in this patient population.

Trial registration

This study registered in the Clinical Research Information Service of the Korea National Institute of Health (approval number: KCT0004735, Date of registration: 21 January 2020, Retrospectively registered).

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Title: Sugammadex is associated with shorter hospital length of stay after open lobectomy for lung cancer: a retrospective observational study
Authors: Seung Won Song
Kyung Yeon Yoo
Yong Sung Ro
Taehee Pyeon
Hong-Beom Bae
Joungmin Kim
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Lung Cancer
Lung Cancer
Lung Cancer
Published in: Journal of Cardiothoracic Surgery / Issue 1/2021
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/s13019-021-01427-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Sugammadex is associated with shorter hospital length of stay after open lobectomy for lung cancer: a retrospective observational study

Abstract

Background

Methods

Results

Conclusions

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

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