Skip to main content
Top
Published in: World Journal of Emergency Surgery 1/2017

Open Access 01-12-2017 | Research article

Lower gastrointestinal bleeding—Computed Tomographic Angiography, Colonoscopy or both?

Authors: Daniel Clerc, Fabian Grass, Markus Schäfer, Alban Denys, Nicolas Demartines, Martin Hübner

Published in: World Journal of Emergency Surgery | Issue 1/2017

Login to get access

Abstract

Background

Lower endoscopy (LE) is the standard diagnostic modality for lower gastrointestinal bleeding (LGIB). Conversely, computed tomographic angiography (CTA) offers an immediate non-invasive diagnosis visualizing the entire gastrointestinal tract. The aim of this study was to compare these 2 modalities with regards to diagnostic value and bleeding control.

Methods

Tertiary center retrospective analysis of consecutive patients admitted for LGIB between 2006 and 2012. Comparison of patients with LE vs. CTA as first exam, respectively, with emphasis on diagnostic accuracy and bleeding control.

Results

Final analysis included 183 patients; 122 (66.7%) had LE first, while 32 (17.5%) had CTA; 29 (15.8%) had neither of both exams. Median time to CTA was shorter compared to LE (3 (IQR = 8.2) vs. 22 (IQR = 36.9) hours, P < 0.001). Active bleeding was identified in 31% with CTA vs. 15% with LE (P = 0.031); a non-actively bleeding source was found by CTA and LE in 22 vs. 31%, respectively (P = 0.305). Bleeding control required endoscopy in 19%, surgery in 14% and embolization in 1.6%, while 66% were treated conservatively. Post-interventional bleeding was mostly controlled by endoscopic therapy (57%). 80% of patients with active bleeding on CTA required surgery.

Conclusions

Post-interventional LGIB was effectively addressed by LE. For other causes of LGIB, CTA was efficient, and more available than colonoscopy. Treatment was conservative for most patients. In case of active bleeding, CTA could localize the bleeding source and predict the need for surgery.
Literature
1.
go back to reference ASGE Standards of Practice Committee, Pasha SF, Shergill A, Acosta RD, Chandrasekhara V, Chathadi KV, Early D, Evans JA, Fisher D, Fonkalsrud L, Hwang JH, Khashab MA, Lightdale JR, Muthusamy VR, Saltzman JR, Cash BD. The role of endoscopy in the patient with lower GI bleeding. Gastrointest Endosc. 2014;79(6):875–85. doi:10.1016/j.gie.2013.10.039. Epub 2014 Apr 2.CrossRef ASGE Standards of Practice Committee, Pasha SF, Shergill A, Acosta RD, Chandrasekhara V, Chathadi KV, Early D, Evans JA, Fisher D, Fonkalsrud L, Hwang JH, Khashab MA, Lightdale JR, Muthusamy VR, Saltzman JR, Cash BD. The role of endoscopy in the patient with lower GI bleeding. Gastrointest Endosc. 2014;79(6):875–85. doi:10.​1016/​j.​gie.​2013.​10.​039. Epub 2014 Apr 2.CrossRef
2.
go back to reference Strate LL. Lower GI, bleeding: epidemiology and diagnosis. Gastroenterol Clin North Am. 2005;34(4):643–64. Review.CrossRefPubMed Strate LL. Lower GI, bleeding: epidemiology and diagnosis. Gastroenterol Clin North Am. 2005;34(4):643–64. Review.CrossRefPubMed
3.
go back to reference Lanas A, García-Rodríguez LA, Polo-Tomás M, Ponce M, Alonso-Abreu I, Perez-Aisa MA, Perez-Gisbert J, Bujanda L, Castro M, Muñoz M, Rodrigo L, Calvet X, Del-Pino D, Garcia S. Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice. Am J Gastroenterol. 2009;104(7):1633–41. doi:10.1038/ajg.2009.164. Epub 2009 May 5.CrossRefPubMed Lanas A, García-Rodríguez LA, Polo-Tomás M, Ponce M, Alonso-Abreu I, Perez-Aisa MA, Perez-Gisbert J, Bujanda L, Castro M, Muñoz M, Rodrigo L, Calvet X, Del-Pino D, Garcia S. Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice. Am J Gastroenterol. 2009;104(7):1633–41. doi:10.​1038/​ajg.​2009.​164. Epub 2009 May 5.CrossRefPubMed
4.
go back to reference Zuccaro Jr G. Management of the adult patient with acute lower gastrointestinal bleeding. American College of Gastroenterology. Practice Parameters Committee. Am J Gastroenterol. 1998;93(8):1202–8.CrossRefPubMed Zuccaro Jr G. Management of the adult patient with acute lower gastrointestinal bleeding. American College of Gastroenterology. Practice Parameters Committee. Am J Gastroenterol. 1998;93(8):1202–8.CrossRefPubMed
6.
go back to reference Geffroy Y, Rodallec MH, Boulay-Coletta I, Jullès MC, Ridereau-Zins C, Zins M. Multidetector CT angiography in acute gastrointestinal bleeding: why, when, and how. Radiographics. 2011;31(3):E35–46. Review. Erratum in: Radiographics. 2011 Sep-Oct;31(5):1496. Radiographics. 2011 Nov-Dec;31(7):2114. Fullès, Marie-Christine [corrected to Jullès, Marie-Christine].CrossRefPubMed Geffroy Y, Rodallec MH, Boulay-Coletta I, Jullès MC, Ridereau-Zins C, Zins M. Multidetector CT angiography in acute gastrointestinal bleeding: why, when, and how. Radiographics. 2011;31(3):E35–46. Review. Erratum in: Radiographics. 2011 Sep-Oct;31(5):1496. Radiographics. 2011 Nov-Dec;31(7):2114. Fullès, Marie-Christine [corrected to Jullès, Marie-Christine].CrossRefPubMed
7.
go back to reference Chan V, Tse D, Dixon S, Shrivastava V, Bratby M, Anthony S, Patel R, Tapping C, Uberoi R. Outcome following a negative CT Angiogram for gastrointestinal hemorrhage. Cardiovasc Intervent Radiol. 2015;38(2):329–35. doi:10.1007/s00270-014-0928-8. Epub 2014 Jul 15.CrossRefPubMed Chan V, Tse D, Dixon S, Shrivastava V, Bratby M, Anthony S, Patel R, Tapping C, Uberoi R. Outcome following a negative CT Angiogram for gastrointestinal hemorrhage. Cardiovasc Intervent Radiol. 2015;38(2):329–35. doi:10.​1007/​s00270-014-0928-8. Epub 2014 Jul 15.CrossRefPubMed
8.
go back to reference Strate LL, Syngal S. Timing of colonoscopy: impact on length of hospital stay in patients with acute lower intestinal bleeding. Am J Gastroenterol. 2003;98(2):317–22.PubMed Strate LL, Syngal S. Timing of colonoscopy: impact on length of hospital stay in patients with acute lower intestinal bleeding. Am J Gastroenterol. 2003;98(2):317–22.PubMed
9.
go back to reference Green BT, Rockey DC, Portwood G, Tarnasky PR, Guarisco S, Branch MS, Leung J, Jowell P. Urgent colonoscopy for evaluation and management of acute lower gastrointestinal hemorrhage: a randomized controlled trial. Am J Gastroenterol. 2005;100(11):2395–402.CrossRefPubMed Green BT, Rockey DC, Portwood G, Tarnasky PR, Guarisco S, Branch MS, Leung J, Jowell P. Urgent colonoscopy for evaluation and management of acute lower gastrointestinal hemorrhage: a randomized controlled trial. Am J Gastroenterol. 2005;100(11):2395–402.CrossRefPubMed
10.
12.
go back to reference Farrell JJ, Friedman LS. Review article: the management of lower gastrointestinal bleeding. Aliment Pharmacol Ther. 2005;21(11):1281–98. Review.CrossRefPubMed Farrell JJ, Friedman LS. Review article: the management of lower gastrointestinal bleeding. Aliment Pharmacol Ther. 2005;21(11):1281–98. Review.CrossRefPubMed
13.
go back to reference Strate LL, Saltzman JR, Ookubo R, Mutinga ML, Syngal S. Validation of a clinical prediction rule for severe acute lower intestinal bleeding. Am J Gastroenterol. 2005;100(8):1821–7.CrossRefPubMed Strate LL, Saltzman JR, Ookubo R, Mutinga ML, Syngal S. Validation of a clinical prediction rule for severe acute lower intestinal bleeding. Am J Gastroenterol. 2005;100(8):1821–7.CrossRefPubMed
14.
go back to reference Jacovides CL, Nadolski G, Allen SR, Martin ND, Holena DN, Reilly PM, Trerotola S, Braslow BM, Kaplan LJ, Pascual JL. Arteriography for lower gastrointestinal hemorrhage: role of preceding abdominal computed tomographic angiogram in diagnosis and localization. JAMA Surg. 2015;150(7):650–6. doi:10.1001/jamasurg.2015.97.CrossRefPubMed Jacovides CL, Nadolski G, Allen SR, Martin ND, Holena DN, Reilly PM, Trerotola S, Braslow BM, Kaplan LJ, Pascual JL. Arteriography for lower gastrointestinal hemorrhage: role of preceding abdominal computed tomographic angiogram in diagnosis and localization. JAMA Surg. 2015;150(7):650–6. doi:10.​1001/​jamasurg.​2015.​97.CrossRefPubMed
15.
go back to reference Strate LL, Ayanian JZ, Kotler G, Syngal S. Risk factors for mortality in lower intestinal bleeding. Clin Gastroenterol Hepatol. 2008 Sep;6(9):1004–10; quiz 955-. doi: 10.1016/j.cgh.2008.03.021. Epub 2008 Jun 16. Strate LL, Ayanian JZ, Kotler G, Syngal S. Risk factors for mortality in lower intestinal bleeding. Clin Gastroenterol Hepatol. 2008 Sep;6(9):1004–10; quiz 955-. doi: 10.​1016/​j.​cgh.​2008.​03.​021. Epub 2008 Jun 16.
16.
go back to reference Parra-Blanco A, Kaminaga N, Kojima T, Endo Y, Uragami N, Okawa N, Hattori T, Takahashi H, Fujita R. Hemoclipping for postpolypectomy and postbiopsy colonic bleeding. Gastrointest Endosc. 2000;51(1):37–41.CrossRefPubMed Parra-Blanco A, Kaminaga N, Kojima T, Endo Y, Uragami N, Okawa N, Hattori T, Takahashi H, Fujita R. Hemoclipping for postpolypectomy and postbiopsy colonic bleeding. Gastrointest Endosc. 2000;51(1):37–41.CrossRefPubMed
17.
go back to reference Sorbi D, Norton I, Conio M, Balm R, Zinsmeister A, Gostout CJ. Postpolypectomy lower GI bleeding: descriptive analysis. Gastrointest Endosc. 2000;51(6):690–6.CrossRefPubMed Sorbi D, Norton I, Conio M, Balm R, Zinsmeister A, Gostout CJ. Postpolypectomy lower GI bleeding: descriptive analysis. Gastrointest Endosc. 2000;51(6):690–6.CrossRefPubMed
18.
go back to reference ASGE Standards of Practice Committee, Fisher DA, Maple JT, Ben-Menachem T, Cash BD, Decker GA, Early DS, Evans JA, Fanelli RD, Fukami N, Hwang JH, Jain R, Jue TL, Khan KM, Malpas PM, Sharaf RN, Shergill AK, Dominitz JA. Complications of colonoscopy. Gastrointest Endosc. 2011;74(4):745–52. doi:10.1016/j.gie.2011.07.025.CrossRef ASGE Standards of Practice Committee, Fisher DA, Maple JT, Ben-Menachem T, Cash BD, Decker GA, Early DS, Evans JA, Fanelli RD, Fukami N, Hwang JH, Jain R, Jue TL, Khan KM, Malpas PM, Sharaf RN, Shergill AK, Dominitz JA. Complications of colonoscopy. Gastrointest Endosc. 2011;74(4):745–52. doi:10.​1016/​j.​gie.​2011.​07.​025.CrossRef
19.
go back to reference Nagata N, Niikura R, Aoki T, Moriyasu S, Sakurai T, Shimbo T, Shinozaki M, Sekine K, Okubo H, Watanabe K, Yokoi C, Yanase M, Akiyama J, Uemura N. Role of urgent contrast-enhanced multidetector computed tomography for acute lower gastrointestinal bleeding in patients undergoing early colonoscopy. J Gastroenterol. 2015;50(12):1162–72. doi:10.1007/s00535-015-1069-9. Epub 2015 Mar 27.CrossRefPubMed Nagata N, Niikura R, Aoki T, Moriyasu S, Sakurai T, Shimbo T, Shinozaki M, Sekine K, Okubo H, Watanabe K, Yokoi C, Yanase M, Akiyama J, Uemura N. Role of urgent contrast-enhanced multidetector computed tomography for acute lower gastrointestinal bleeding in patients undergoing early colonoscopy. J Gastroenterol. 2015;50(12):1162–72. doi:10.​1007/​s00535-015-1069-9. Epub 2015 Mar 27.CrossRefPubMed
20.
go back to reference Koh FH, Soong J, Lieske B, Cheong WK, Tan KK. Does the timing of an invasive mesenteric angiography following a positive CT mesenteric angiography make a difference? Int J Colorectal Dis. 2015;30(1):57–61. doi:10.1007/s00384-014-2055-z. Epub 2014 Nov 4.CrossRefPubMed Koh FH, Soong J, Lieske B, Cheong WK, Tan KK. Does the timing of an invasive mesenteric angiography following a positive CT mesenteric angiography make a difference? Int J Colorectal Dis. 2015;30(1):57–61. doi:10.​1007/​s00384-014-2055-z. Epub 2014 Nov 4.CrossRefPubMed
22.
go back to reference Sabharwal R, Vladica P, Chou R, Law WP. Helical CT in the diagnosis of acute lower gastrointestinal haemorrhage. Eur J Radiol. 2006;58(2):273–9. Epub 2006 Jan 18.CrossRefPubMed Sabharwal R, Vladica P, Chou R, Law WP. Helical CT in the diagnosis of acute lower gastrointestinal haemorrhage. Eur J Radiol. 2006;58(2):273–9. Epub 2006 Jan 18.CrossRefPubMed
Metadata
Title
Lower gastrointestinal bleeding—Computed Tomographic Angiography, Colonoscopy or both?
Authors
Daniel Clerc
Fabian Grass
Markus Schäfer
Alban Denys
Nicolas Demartines
Martin Hübner
Publication date
01-12-2017
Publisher
BioMed Central
Published in
World Journal of Emergency Surgery / Issue 1/2017
Electronic ISSN: 1749-7922
DOI
https://doi.org/10.1186/s13017-016-0112-3

Other articles of this Issue 1/2017

World Journal of Emergency Surgery 1/2017 Go to the issue