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01-05-2013 | Original Article

Low-level laser therapy in experimental model of collagenase-induced tendinitis in rats: effects in acute and chronic inflammatory phases

Authors: Heliodora Leão Casalechi, Ernesto Cesar Pinto Leal-Junior, Murilo Xavier, José Antônio Silva Jr., Paulo de Tarso Camillo de Carvalho, Flávio Aimbire, Regiane Albertini

Published in: Lasers in Medical Science | Issue 3/2013

Abstract

A variety of treatments for tendinopathies is currently used or has been trialed. However, in fact, there is a remarkably little evidence that any conventional therapies are effective. In the last years, low-level laser therapy (LLLT) has been showing interesting results in inflammatory modulation in different musculoskeletal disorders, but the optimal parameters and mechanisms behind these effects are not fully understood. The aim of this study is to investigate if the LLLT modulates the acute and chronic phase of collagenase-induced tendinitis in rat by interfering in mRNA expression for matrix metalloproteinases (MMP13 and MMP1), vascular endothelial growth factor (VEGF), and anti-inflammatory mediator (interleukin (IL)-10). For such, tendinitis was induced by collagenase injection in male Wistar rats. Animals were treated with LLLT (780 nm, potency of 22 mW, 107 mW/cm², energy density of 7.5 J/cm², and energy delivered of 1.54 J) with different number of treatments in accordance with the inflammatory phase analyzed. LLLT was able to modulate mRNA gene expression of IL-10, VGEF, MMP1, and MMP13 both in acute than in chronic inflammatory phase (p < 0.05). Our results suggest that LLLT with parameters employed in the present study was able to modulate IL-10, VEGF, MMP1, and MMP13 mRNA gene expression both in acute than in chronic tendon inflammation. However, further studies are needed to establish optimal parameters for LLLT.

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Title: Low-level laser therapy in experimental model of collagenase-induced tendinitis in rats: effects in acute and chronic inflammatory phases
Authors: Heliodora Leão Casalechi
Ernesto Cesar Pinto Leal-Junior
Murilo Xavier
José Antônio Silva Jr.
Paulo de Tarso Camillo de Carvalho
Flávio Aimbire
Regiane Albertini
Publication date: 01-05-2013
Publisher: Springer-Verlag
Published in: Lasers in Medical Science / Issue 3/2013
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-012-1189-x

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Low-level laser therapy in experimental model of collagenase-induced tendinitis in rats: effects in acute and chronic inflammatory phases

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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