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01-04-2016 | Original Article

Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384

Authors: Juxiang Huang, Lin Wang, Minghu Jiang, Qingchun Chen, Xiaoyu Zhang, Yangming Wang, Zhenfu Jiang, Zhongjie Zhang

Published in: Immunologic Research | Issue 2/2016

Abstract

Eighteen different Pearson mutual-positive-correlation BIK-activatory molecular feedback upstream and downstream networks were constructed from 79 overlapping of 376 GRNInfer and 98 Pearson under BIK CC ≥0.25 in low normal adjacent tissues of Taiwan compared with high lung adenocarcinoma. Our identified BIK interactive total feedback molecular network showed FUT3 [fucosyltransferase 3 (galactoside 3(4)-l-fucosyltransferase Lewis blood group)], PMM2 (phosphomannomutase 2), SQSTM1 (sequestosome 1), SFN_2 [REX2 RNA exonuclease 2 homolog (S. cerevisiae)] and ZNF384 (zinc finger protein 384) in low normal adjacent tissues of lung adenocarcinoma. BIK interactive total feedback terms included mitochondrial envelope, endomembrane system, integral to membrane, Golgi apparatus, cytoplasm, nucleus, cytosol, intracellular signaling cascade, mitochondrion, extracellular space, inflammation, immune response, apoptosis, cell differentiation, cell cycle, regulation of cell cycle, cell proliferation, estrogen-responsive protein Efp controls cell cycle and breast tumors growth, induction or regulation of apoptosis based on integrative GO, KEGG, GenMAPP, BioCarta and disease databases in low normal adjacent tissues of lung adenocarcinoma. Therefore, we propose low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384 in normal adjacent tissues of lung adenocarcinoma.

Zhu L, Han MB, Gao Y, Wang H, Dai L, Wen Y, et al. Curcumin triggers apoptosis via upregulation of Bax/Bcl-2 ratio and caspase activation in SW872 human adipocytes. Mol Med Rep. 2015;. doi:10.3892/mmr.2015.3450.

Zhou Y, Liu QH, Liu CL, Lin L. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Tumour Biol. 2015;. doi:10.1007/s13277-015-3194-8.

Li CL, Chang L, Guo L, Zhao D, Liu HB, Wang QS, et al. beta-elemene induces caspase-dependent apoptosis in human glioma cells in vitro through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. Asian Pac J Cancer Prev. 2014;15(23):10407–12.CrossRefPubMed

Wan C, Ma X, Shi S, Zhao J, Nie X, Han J, et al. Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis. Toxicol Appl Pharmacol. 2014;281(3):294–302. doi:10.1016/j.taap.2014.10.013.CrossRefPubMed

Jin Z, Zheng L, Xin X, Li Y, Hua T, Wu T, et al. Upregulation of forkhead box O3 transcription is involved in C2-ceramide induced apoptosis and autophagy in ovarian cancer cells in vitro. Mol Med Rep. 2014;10(6):3099–105. doi:10.3892/mmr.2014.2664.PubMed

Ridinger-Saison M, Evanno E, Gallais I, Rimmele P, Selimoglu-Buet D, Sapharikas E, et al. Epigenetic silencing of Bim transcription by Spi-1/PU.1 promotes apoptosis resistance in leukaemia. Cell Death Differ. 2013;20(9):1268–78. doi:10.1038/cdd.2013.88.CrossRefPubMedPubMedCentral

Storey JD. A direct approach to false discovery rates. J R Stat Soc Ser B. 2002;64:479–98.CrossRef

Wang L, Huang J, Jiang M, Sun L. MYBPC1 computational phosphoprotein network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients. Cell Mol Neurobiol. 2011;31(2):233–41. doi:10.1007/s10571-010-9613-x.CrossRefPubMed

Wang L, Huang J, Jiang M. CREB5 computational regulation network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients. Cell Biochem Biophys. 2011;60(3):199–207.CrossRefPubMed

10.

Wang L, Huang J, Jiang M, Zheng X. AFP computational secreted network construction and analysis between human hepatocellular carcinoma (HCC) and no-tumor hepatitis/cirrhotic liver tissues. Tumor Biol. 2010;31(5):417–25.CrossRef

11.

Wang L, Huang J, Jiang M. RRM2 computational phosphoprotein network construction and analysis between no-tumor hepatitis/cirrhotic liver tissues and human hepatocellular carcinoma (HCC). Cell Physiol Biochem. 2010;26(3):303–10.CrossRefPubMed

12.

Huang JX, Wang L, Jiang MH. TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients. J Inflamm (Lond). 2010;7:50.CrossRef

13.

You J, Wang L, Huang J, Jiang M, Chen Q, Wang Y, et al. Low glucose transporter SLC2A5-inhibited human normal adjacent lung adenocarcinoma cytoplasmic pro-B cell development mechanism network. Mol Cell Biochem. 2015;399(1–2):71–6. doi:10.1007/s11010-014-2233-x.CrossRefPubMed

14.

Huang J, Wang L, Jiang M, Chen Q, Jiang Z, Feng H. AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response. Cell Immunol. 2014;290(1):102–6. doi:10.1016/j.cellimm.2014.05.008.CrossRefPubMed

15.

Wang L, Huang J, Jiang M, Diao H, Zhou H, Li X, et al. Cartilage oligomeric matrix protein (COMP)-mediated cell differentiation to proteolysis mechanism networks from human normal adjacent tissues to lung adenocarcinoma. Anal Cell Pathol (Amst). 2013;36(3–4):93–105. doi:10.3233/ACP-130084.CrossRef

16.

Sun Y, Wang L, Jiang M, Huang J, Liu Z, Wolfl S. Secreted phosphoprotein 1 upstream invasive network construction and analysis of lung adenocarcinoma compared with human normal adjacent tissues by integrative biocomputation. Cell Biochem Biophys. 2010;56(2–3):59–71.CrossRefPubMed

17.

Wang L, Huang J, Jiang M, Diao H, Zhou H, Li X, et al. Adenosylmethionine decarboxylase 1 (AMD1)-mediated mRNA processing and cell adhesion activated & inhibited transition mechanisms by different comparisons between chimpanzee and human left hemisphere. Cell Biochem Biophys. 2014;70(1):279–88. doi:10.1007/s12013-014-9902-y.CrossRefPubMed

18.

Diao H, Wang L, Huang J, Jiang M, Zhou H, Li X, et al. BRCA1-mediated inflammation and growth activated & inhibited transition mechanisms by different comparisons between no-tumor hepatitis/cirrhotic tissues and HCC. J Cell Biochem. 2013;115(4):641–50. doi:10.1002/jcb.24699.CrossRef

19.

Wang Y, Joshi T, Zhang XS, Xu D, Chen L. Inferring gene regulatory networks from multiple microarray datasets. Bioinformatics (Oxford, England). 2006;22(19):2413–20.CrossRef

20.

Sun L, Wang L, Jiang M, Huang J, Lin H. Glycogen debranching enzyme 6 (AGL), enolase 1 (ENOSF1), ectonucleotide pyrophosphatase 2 (ENPP2_1), glutathione S-transferase 3 (GSTM3_3) and mannosidase (MAN2B2) metabolism computational network analysis between chimpanzee and human left cerebrum. Cell Biochem Biophys. 2011;61(3):493–505.CrossRefPubMed

21.

Wang L, Sun L, Huang J, Jiang M. Cyclin-dependent kinase inhibitor 3 (CDKN3) novel cell cycle computational network between human non-malignancy associated hepatitis/cirrhosis and hepatocellular carcinoma (HCC) transformation. Cell Prolif. 2011;44(3):291–9.CrossRefPubMed

22.

Wang L, Huang J, Jiang M, Sun L. Survivin (BIRC5) cell cycle computational network in human no-tumor hepatitis/cirrhosis and hepatocellular carcinoma transformation. J Cell Biochem. 2011;112(5):1286–94.CrossRefPubMed

23.

Wang L, Sun Y, Jiang M, Zheng X. Integrative decomposition procedure and Kappa statistics for the distinguished single molecular network construction and analysis. J Biomed Biotechnol. 2009;2009:726728.PubMedPubMedCentral

24.

Wang L, Sun Y, Jiang M, Zhang S, Wolfl S. FOS proliferating network construction in early colorectal cancer (CRC) based on integrative significant function cluster and inferring analysis. Cancer Invest. 2009;27(8):816–24.CrossRefPubMed

25.

Wang L, Huang J, Jiang M, Chen Q, Jiang Z, Feng H. CAMK1 phosphoinositide signal-mediated protein sorting and transport network in human hepatocellular carcinoma (HCC) by biocomputation. Cell Biochem Biophys. 2014;70(2):1011–6. doi:10.1007/s12013-014-0011-8.CrossRefPubMed

26.

Qi L, Wang L, Huang J, Jiang M, Diao H, Zhou H, et al. Activated amelogenin Y-linked (AMELY) regulation and angiogenesis in human hepatocellular carcinoma by biocomputation. Oncol Lett. 2013;5(3):1075–9. doi:10.3892/ol.2013.1122.PubMedPubMedCentral

27.

Wang L, Huang J, Jiang M, Lin H, Qi L, Diao H. Activated PTHLH coupling feedback phosphoinositide to G-protein receptor signal-induced cell adhesion network in human hepatocellular carcinoma by systems-theoretic analysis. Sci World J. 2012;2012:428979. doi:10.1100/2012/428979.

28.

Wang L, Huang J, Jiang M, Lin H, Qi L, Diao H. Inhibited PTHLH downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by systems-theoretical analysis. Integr Biol (Camb). 2012;4(10):1256–62. doi:10.1039/c2ib20148h.CrossRef

29.

Wang L, Huang J, Jiang M, Lin H. Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by biocomputation. Immunol Res. 2012;52(3):258–68.CrossRefPubMed

30.

Wang L, Huang J, Jiang M, Lin H. Signal transducer and activator of transcription 2 (STAT2) metabolism coupling postmitotic outgrowth to visual and sound perception network in human left cerebrum by biocomputation. J Mol Neurosci. 2012;47(3):649–58. doi:10.1007/s12031-011-9702-4.CrossRefPubMed

31.

Lin H, Wang L, Jiang M, Huang J, Qi L. P-glycoprotein (ABCB1) inhibited network of mitochondrion transport along microtubule and BMP signal-induced cell shape in chimpanzee left cerebrum by systems-theoretical analysis. Cell Biochem Funct. 2012;30(7):582–7. doi:10.1002/cbf.2837.CrossRefPubMed

32.

Huang J, Wang L, Jiang M, Lin H, Qi L, Diao H. PTHLH coupling upstream negative regulation of fatty acid biosynthesis and Wnt receptor signal to downstream peptidase activity-induced apoptosis network in human hepatocellular carcinoma by systems-theoretical analysis. J Recept Signal Transduct Res. 2012;32(5):250–6. doi:10.3109/10799893.2012.700717.CrossRefPubMed

33.

Akamatsu S, Yazawa S, Zenita K, Matsumoto H, Tachikawa T, Kannagi R. Elevation of an alpha(1,3)fucosyltransferase activity correlated with apoptosis in the human colon adenocarcinoma cell line, HT-29. Glycoconj J. 1996;13(6):1021–9.CrossRefPubMed

34.

Wang H, Wang QY, Zhang Y, Shen ZH, Chen HL. Alpha 1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells. Glycoconj J. 2007;24(4–5):207–20. doi:10.1007/s10719-007-9028-1.CrossRefPubMed

35.

Kawase T, Ichikawa H, Ohta T, Nozaki N, Tashiro F, Ohki R, et al. p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis. Oncogene. 2008;27(27):3797–810. doi:10.1038/onc.2008.32.CrossRefPubMed

36.

Meng XW, Fraser MJ, Feller JM, Ziegler JB. Caspase-3 activates endo-exonuclease: further evidence for a role of the nuclease in apoptosis. Apoptosis. 2000;5(3):243–54.CrossRefPubMed

37.

Wasim M, Mansha M, Kofler A, Awan AR, Babar ME, Kofler R. Promyelocytic leukemia zinc finger protein (PLZF) enhances glucocorticoid-induced apoptosis in leukemic cell line NALM6. Pak J Pharm Sci. 2012;25(3):617–21.PubMed

38.

Xiao Y, Xiang T, Luo X, Li C, Li Q, Peng W, et al. Zinc-finger protein 545 inhibits cell proliferation as a tumor suppressor through inducing apoptosis and is disrupted by promoter methylation in breast cancer. PLoS One. 2014;9(10):e110990. doi:10.1371/journal.pone.0110990.CrossRefPubMedPubMedCentral

39.

Yang X, Liu Y, Liu J, Wang X, Yan Q. Cyclophosphamide-induced apoptosis in A431 cells is inhibited by fucosyltransferase IV. J Cell Biochem. 2011;112(5):1376–83. doi:10.1002/jcb.23054.CrossRefPubMed

40.

Zhou L, Wang HF, Ren HG, Chen D, Gao F, Hu QS, et al. Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro. Acta Pharmacol Sin. 2013;34(5):651–6. doi:10.1038/aps.2013.12.CrossRefPubMedPubMedCentral

41.

Li Y, Tan BB, Zhao Q, Fan LQ, Liu Y, Wang D. Regulatory mechanism of ZNF139 in multi-drug resistance of gastric cancer cells. Mol Biol Rep. 2014;41(6):3603–10. doi:10.1007/s11033-014-3224-4.CrossRefPubMed

Title: Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384
Authors: Juxiang Huang
Lin Wang
Minghu Jiang
Qingchun Chen
Xiaoyu Zhang
Yangming Wang
Zhenfu Jiang
Zhongjie Zhang
Publication date: 01-04-2016
Publisher: Springer US
Published in: Immunologic Research / Issue 2/2016
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-015-8701-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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