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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-04-2018 | Original Article

Low baseline and subsequent higher aortic abdominal aneurysm FDG uptake are associated with poor sac shrinkage post endovascular repair

Authors: Pierre-Yves Marie, Didier Plissonnier, Stéphanie Bravetti, Raphael Coscas, Martin Rouer, Stéphan Haulon, Damien Mandry, Jean-Marc Alsac, Sergueï Malikov, Nicla Settembre, Yann Gouëffic, Olivier Morel, Véronique Roch, Emilien Micard, Zohra Lamiral, Jean-Baptiste Michel, Patrick Rossignol

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 4/2018

Abstract

Purpose

The growth phases of medically treated abdominal aortic aneurysms (AAA) are frequently associated with an ¹⁸F–fluorodesoxyglucose positron emission tomography (FDG-PET) pattern involving low baseline and subsequent higher FDG uptake. However, the FDG-PET patterns associated with the endovascular aneurysm repair (EVAR) of larger AAA are presently unknown. This study aimed to investigate the relationship between serial AAA FDG uptake measurements, obtained before EVAR and 1 and 6 months post-intervention and subsequent sac shrinkage at 6 months, a well-recognized indicator of successful repair.

Methods

Thirty-three AAA patients referred for EVAR (maximal diameter: 55.4 ± 6.0 mm, total volume: 205.7 ± 63.0 mL) underwent FDG-PET/computed tomography (CT) before EVAR and at 1 and 6 months thereafter, with the monitoring of AAA volume and of a maximal standardized FDG uptake [SUVmax] averaged between the axial slices encompassing the AAA.

Results

Sac shrinkage was highly variable and could be stratified into three terciles: a first tercile in which shrinkage was absent or very limited (0–29 mL) and a third tercile with pronounced shrinkage (56–165 mL). SUVmax values were relatively low at baseline in the 1st tercile (SUVmax: 1.69 ± 0.33), but markedly increased at 6 months (2.42 ± 0.69, p = 0.02 vs. baseline). These SUV max values were by contrast much higher at baseline in the 3rd tercile (SUVmax: 2.53 ± 0.83 p = 0.009 vs. 1st tercile) and stable at 6 months (2.49 ± 0.80), while intermediate results were documented in the 2nd tercile. Lastly, the amount of sac shrinkage, expressed in absolute values or in percentages of baseline AAA volumes, was positively correlated with baseline SUVmax (p = 0.001 for both).

Conclusion

A low pre-EVAR FDG uptake and increased AAA FDG uptake at 6 months are associated with reduced sac shrinkage. This sequential FDG-PET pattern is similar to that already shown to accompany growth phases of medically treated AAA.

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Title: Low baseline and subsequent higher aortic abdominal aneurysm FDG uptake are associated with poor sac shrinkage post endovascular repair
Authors: Pierre-Yves Marie
Didier Plissonnier
Stéphanie Bravetti
Raphael Coscas
Martin Rouer
Stéphan Haulon
Damien Mandry
Jean-Marc Alsac
Sergueï Malikov
Nicla Settembre
Yann Gouëffic
Olivier Morel
Véronique Roch
Emilien Micard
Zohra Lamiral
Jean-Baptiste Michel
Patrick Rossignol
Publication date: 01-04-2018
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 4/2018
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-017-3883-1

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Low baseline and subsequent higher aortic abdominal aneurysm FDG uptake are associated with poor sac shrinkage post endovascular repair

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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