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Open Access 01-12-2015 | Letter to the Editor

Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells

Authors: Yiren Xiao, Xinru Wei, Zhiwu Jiang, Xiangmeng Wang, Wei Ye, Xin Liu, Minjie Zhang, Yan Xu, Donghai Wu, Liangxue Lai, Huihui Yao, Zixia Liu, Su Cao, Pentao Liu, Bing Xu, Yangqiu Li, Yao Yao, Duanqing Pei, Peng Li

Published in: Journal of Hematology & Oncology | Issue 1/2015

Abstract

Successful expansion of hematopoietic stem cells (HSCs) would benefit the use of HSC transplants in the clinic. Angiopoietin-like 7 promotes the expansion of hematopoietic stem and progenitor cells (HSPC) in vitro and ex vivo. However, the impact of loss of Angptl7 on HSPCs in vivo has not been characterized. Here, we generated Angptl7-deficient mice by TALEN-mediated gene targeting and found that HSC compartments in Angptl7-null mice were compromised. In addition, wild type (WT) HSPCs failed to repopulate in the BM of Angptl7-null mice after serial transplantations while the engraftment of Angptl7-deficient HSPCs in WT mice was not impaired. These results suggest that Angptl7 is required for HSPCs repopulation in a non-cell autonomous manner.

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Title: Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells
Authors: Yiren Xiao
Xinru Wei
Zhiwu Jiang
Xiangmeng Wang
Wei Ye
Xin Liu
Minjie Zhang
Yan Xu
Donghai Wu
Liangxue Lai
Huihui Yao
Zixia Liu
Su Cao
Pentao Liu
Bing Xu
Yangqiu Li
Yao Yao
Duanqing Pei
Peng Li
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Journal of Hematology & Oncology / Issue 1/2015
Electronic ISSN: 1756-8722
DOI: https://doi.org/10.1186/s13045-014-0102-4

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