Top

Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie

Published in:

01-09-2015 | Original article

Longitudinal relationship between insulin-like growth factor-1 levels and vertical facial growth

Authors: M.I. Masoud, BDS, DMSc., H.Y.A. Marghalani, N.M. Alamoudi, D. El Derw, I.M. Masoud, N.F. Gowharji

Published in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie | Issue 5/2015

Abstract

Background

Facial growth in the vertical dimension is the last to be completed and can often be detrimental to the success of dental implants, orthodontic treatment, and orthognathic surgery that young individuals undergo.

Aim

The purpose of this study was to evaluate the longitudinal relationship between changes in total anterior facial height and insulin-like growth factor-1 (IGF-1) levels measured using blood-spot samples.

Methods

Our sample included 25 orthodontic patients from whom we had access to annual lateral cephalometric radiographs and IGF-1 measurements. Each subject was observed between 2 and 6 times, resulting in 43 annual intervals from a total of 77 observations.

Results

We noted a significant moderate positive correlation (+ 0.48) between the percentage of change in blood-spot IGF-1 levels and the percentage of change in total anterior face height (p = 0.01).

Conclusion

Longitudinal changes in IGF-1 levels can be used to predict a patient’s vertical facial growth. There was no significant correlation between changes in vertical facial development and a single cross-sectional IGF-1 measurement.

Abu EO, Horner A, Kusec V et al (1997) The localization of androgen receptors in human bone. J Clin Endocrinol Metab 82(10):3493–3497CrossRefPubMed

Alkumru P, Erdem D, Altug-Atac AT (2007) Evaluation of changes in the vertical facial dimension with different anchorage systems in extraction and non-extraction subjects treated by Begg fixed appliances: a retrospective study. Eur J Orthod 29(5):508–516CrossRefPubMed

Baccetti T, Franchi L, McNamara J (2005) The Cervical Vertebral Maturation (CVM) method for the assessment of optimal treatment timing in dentofacial orthopedics. Semin Orthod 11:119–129CrossRef

Bonert V (2009) Diagnostic challenges in acromegaly: a case-based review. Best Pract Res Clin Endocrinol Metab 23(Suppl 1):S23–S30CrossRefPubMed

Carani C, Qin K, Simoni M et al (1997) Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 337(2):91–95CrossRefPubMed

Carlson DS (1976) Temporal variation in prehistoric Nubian crania. Am J Phys Anthropol 45:467–484CrossRefPubMed

Carlson DS, Van Gerven DP (1977) Masticatory function and Post-Pleistocene evolution in Nubia. Am J Phys Anthropol 46:495–506CrossRefPubMed

Corruccini RS, Beecher R (1982) Occlusal variation related to soft diet in a nonhuman primate. Science 218:74–76CrossRefPubMed

Corruccini RS (1984) An epidemiologic transition in dental occlusion in world populations. Am J Orthod 86:419–426CrossRefPubMed

10.

Corruccini RS, Beecher R (1984) Occlusofacial morphological integration lowered in baboons raised on soft diet. J Craniofac Genet Dev Biol 4:135–142PubMed

11.

Corruccini RS (1990) Australian aboriginal tooth succession, interproximal attrition, and Begg’s theory. Am J Orthod Dentofacial Orthop 97:349–357CrossRefPubMed

12.

Delatte M, Von den Hoff JW, Maltha JC, Kuijpers-Jagtman AM (2004) Growth stimulation of mandibular condyles and femoral heads of newborn rats by IGF-I. Arch Oral Biol 49(3):165–175CrossRefPubMed

13.

Diamandi A, Khosravi MJ, Mistry J et al (1998) Filter paper blood spot assay of human insulin-like growth factor I (IGF-I) and IGF-binding protein-3 and preliminary application in the evaluation of growth hormone status. J Clin Endocrinol Metab 83(7):2296–2301CrossRefPubMed

14.

Fishman LS (1982) Radiographic evaluation of skeletal maturation. A clinically oriented method based on hand-wrist films. Angle Orthod 52:88–112PubMed

15.

Franchi L, Baccetti T, McNamara JA Jr (2000) Mandibular growth as related to cervical vertebral maturation and body height. Am J Orthod Dentofacial Orthop 118:335–340CrossRefPubMed

16.

Frasier SD (1974) A review of growth hormone stimulation tests in children. Pediatrics 53:929–937PubMed

17.

Goto S, Kondo T, Negoro T et al (1996) Ossification of the distal phalanx of the first digit as a maturity indicator for initiation of orthodontic treatment of Class III malocclusion in Japanese women. Am J Orthod Dentofacial Orthop 110(5):490–501CrossRefPubMed

18.

Greulich WW, Pyle SI (1959) Radiographic atlas of the skeletal development of the hand and wrist, 2nd edn. Stanford University Press, Palo Alto

19.

Hawkes CP, Grimberg A (2013) Measuring growth hormone and insulin-like growth factor-I in infants: what is normal? Pediatr Endocrinol Rev 11(2):126–146PubMedCentralPubMed

20.

Helm S, Siersbaek-Nielsen S, Skieller V et al (1971) Skeletal maturation of the hand in relation to maximum puberal growth in body height. Tandlaegebladet 75(12):1223–1234PubMed

21.

Ishaq RA, Soliman SA, Foda MY et al (2012) Insulin-like growth factor I: a biologic maturation indicator. Am J Orthod Dentofacial Orthop 142(5):654–661CrossRefPubMed

22.

Lamparski DG (1972) Skeletal age assessment utilizing cervical vertebrae. Master’s thesis. Pittsburgh: Penn: Department of Orthodontics, the University of Pittsburgh

23.

Le Roith D, Bondy C, Yakar S et al (2001) The somatomedin hypothesis: 2001. Endocr Rev 22:53–74CrossRef

24.

Lieberman DE, Krovitz GE, Yates FW et al (2004) Effects of food processing on masticatory strain and craniofacial growth in a retrognathic face. J Hum Evol 46(6):655–677CrossRefPubMed

25.

Masoud M, Masoud I, Kent RL Jr et al (2008) Assessing skeletal maturity by using blood-spot insulin-like growth factor I (IGF-I) testing. Am J Orthod Dentofacial Orthop 134(2):209–216CrossRefPubMed

26.

Masoud MI, Masoud I, Kent RL Jr et al (2009) Relationship between blood-spot insulin-like growth factor 1 levels and hand-wrist assessment of skeletal maturity. Am J Orthod Dentofacial Orthop 136(1):59–64CrossRefPubMed

27.

Masoud MI, Marghalani HY, Masoud IM et al (2012) Prospective longitudinal evaluation of the relationship between changes in mandibular length and blood-spot IGF-1 measurements. Am J Orthod Dentofacial Orthop 141(6):694–704CrossRefPubMed

28.

Mitani H, Sato K, Sugawara J (1993) Growth of mandibular prognathism after pubertal growth peak. Am J Orthod Dentofacial Orthop 104(4):330–336CrossRefPubMed

29.

Mohan S, Richman C, Guo R et al (2003) Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanisms. Endocrinology 144:929–936PubMedCentralCrossRefPubMed

30.

Patil AS, Sable RB, Kothari RM (2012) Role of insulin-like growth factors (IGFs), their receptors and genetic regulation in the chondrogenesis and growth of the mandibular condylar cartilage. J Cell Physiol 227(5):1796–1804. doi:10.1002/jcp.22905CrossRefPubMed

31.

Phillip M, Maor G, Assa S et al (2001) Testosterone stimulates growth of tibial epiphyseal growth plate and insulin-like growth factor-1 receptor abundance in hypophysectomized and castrated rats. Endocrine 16(1):1–6CrossRefPubMed

32.

Pokrajac A, Wark G, Ellis AR et al (2007) Variation in GH and IGF-I assays limits the applicability of international consensus criteria to local practice. Clin Endocrinol (Oxford) 67:65–70

33.

Rabie AB, Hagg U (2002) Factors regulating mandibular condylar growth. Am J Orthod Dentofacial Orthop 122(4):401–409CrossRefPubMed

34.

Ren SG, Malozowski S, Sanchez P et al (1989) Direct administration of testosterone increases rat tibial epiphyseal growth plate width. Acta Endocrinol (Copenh) 121(3):401–405

35.

Rosenfeld RG, Albertsson-Wikland K, Cassorla F et al (1995) Diagnostic controversy: the diagnosis of childhood growth hormone deficiency revisited. J Clin Endocrinol Metab 80:1532–1540PubMed

36.

Rosenfeld RG (1996) Biochemical diagnostic strategies in the evaluation of short stature: the diagnosis of insulin-like growth factor deficiency. Horm Res 46:170–173CrossRefPubMed

37.

Rosenfeld RG (1997) Is growth hormone deficiency a viable diagnosis? J Clin Endocrinol Metab 82(2):349–351CrossRefPubMed

38.

Salmon WD Jr, Daughaday WH (1957) A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med 49:825–836PubMed

39.

Sheng MH, Lau KH, Baylink DJ (2014) Role of osteocyte-derived insulin-like growth factor I in developmental growth, modeling, remodeling, and regeneration of the bone. J Bone Metab 21(1):41–54PubMedCentralCrossRefPubMed

40.

Spear FM, Mathews DM, Kokich VG (1997) Interdisciplinary management of single-tooth implants. Semin Orthod 3(1):45–72CrossRefPubMed

41.

SROBE checklist. http://www.strobe-statement.org/fileadmin/Strobe/uploads/checklists/STROBE_checklist_v4_cohort.pdf. Accessed 05 May 2015

42.

Suzuki S, Itoh K, Ohyama K (2004) Local administration of IGF-I stimulates the growth of mandibular condyle in mature rats. J Orthod 31(2):138–143CrossRefPubMed

43.

Tanner JM, Whitehouse RH, Cameron N et al (1975) Assessment of skeletal maturity and prediction of adult height (TW2 Method), 2nd edn. Academic Press, London

44.

Van der Eerden BC, Lowik CW, Wit JM et al (2004) Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation. J Endocrinol 180(3):457–467CrossRef

45.

Woods KA, Camacho-Hubner C, Savage MO, Clark AJI (1996) Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor-I gene. N Engl J Med 335:1363–1367CrossRefPubMed

46.

Yakar S, Rosen CJ, Beamer WG et al (2002) Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest 110(6):771–781PubMedCentralCrossRefPubMed

Title: Longitudinal relationship between insulin-like growth factor-1 levels and vertical facial growth
Authors: M.I. Masoud, BDS, DMSc.
H.Y.A. Marghalani
N.M. Alamoudi
D. El Derw
I.M. Masoud
N.F. Gowharji
Publication date: 01-09-2015
Publisher: Springer Berlin Heidelberg
Published in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie / Issue 5/2015
Print ISSN: 1434-5293
Electronic ISSN: 1615-6714
DOI: https://doi.org/10.1007/s00056-015-0305-5

At a glance: The STEP trials

Springer Medicine

Longitudinal relationship between insulin-like growth factor-1 levels and vertical facial growth

Abstract

Background

Aim

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Aim

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 5/2015

Pain reduced by low-level laser therapy during use of orthodontic separators in early mixed dentition

Effects of different orthodontic primers on enamel demineralization around orthodontic brackets

Editorial

Three-dimensional analysis of maxillary development in patients with unilateral cleft lip and palate during the first six years of life

Symmetric and asymmetric expansion of molars using a Burstone-type transpalatal arch

Mitteilungen