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01-07-2016 | Original Article

Longitudinal patterns of urine biomarkers in infants across gestational ages

Authors: Marissa J. DeFreitas, Wacharee Seeherunvong, Chryso P. Katsoufis, Satish RamachandraRao, Shahnaz Duara, Salih Yasin, Gaston Zilleruelo, Maria M. Rodriguez, Carolyn L. Abitbol

Published in: Pediatric Nephrology | Issue 7/2016

Abstract

Background

Urinary biomarkers may be indicators of acute kidney injury (AKI), although little is known of their developmental characteristics in healthy neonates across a full range of gestational age (GA). The purpose of this study was to examine patterns of urinary biomarkers across GA groups from birth to 3 months of age.

Methods

Fifty-two infants ranging from 24 to 41 weeks’ GA had urine assayed from birth through 3 months of age for 7 biomarkers including albumin (ALB), beta-2-microglobulin (B2M), cystatin-C (CysC), epidermal growth factor (EGF), neutrophil-gelatinase-associated lipocalin (NGAL), osteopontin (OPN), and uromodulin (UMOD).

Results

Of the seven urinary biomarkers, EGF and UMOD increased while others decreased with advancing GA. By 3 months of age, EGF and UMOD had increased in preterm infants to levels similar to those of term infants. UMOD/ml and EGF/ml appeared to be predominantly developmental biomarkers distinguishing estimated glomerular filtration rate (GFR) <30 ml/min/1.73 m² with receiver operator characteristic area under the curve (ROC-AUC) of 0.82; p = 0.002. When factored by urine creatinine CysC/cr + ALB/cr were the most significant functional markers with AUC = 0.79; p = 0.004; sensitivity 96 %; specificity 58 %.

Conclusions

Among healthy neonates, urinary biomarkers vary with GA. These data support the use of urinary biomarkers in the assessment of normal kidney development in the absence of injury.

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Title: Longitudinal patterns of urine biomarkers in infants across gestational ages
Authors: Marissa J. DeFreitas
Wacharee Seeherunvong
Chryso P. Katsoufis
Satish RamachandraRao
Shahnaz Duara
Salih Yasin
Gaston Zilleruelo
Maria M. Rodriguez
Carolyn L. Abitbol
Publication date: 01-07-2016
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 7/2016
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-016-3327-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Longitudinal patterns of urine biomarkers in infants across gestational ages

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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