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Open Access 01-06-2018 | Original Communication

Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia

Authors: Lize C. Jiskoot, Jessica L. Panman, Lauren van Asseldonk, Sanne Franzen, Lieke H. H. Meeter, Laura Donker Kaat, Emma L. van der Ende, Elise G. P. Dopper, Reinier Timman, Rick van Minkelen, John C. van Swieten, Esther van den Berg, Janne M. Papma

Published in: Journal of Neurology | Issue 6/2018

Abstract

Introduction

We performed 4-year follow-up neuropsychological assessment to investigate cognitive decline and the prognostic abilities from presymptomatic to symptomatic familial frontotemporal dementia (FTD).

Methods

Presymptomatic MAPT (n = 15) and GRN mutation carriers (n = 31), and healthy controls (n = 39) underwent neuropsychological assessment every 2 years. Eight mutation carriers (5 MAPT, 3 GRN) became symptomatic. We investigated cognitive decline with multilevel regression modeling; the prognostic performance was assessed with ROC analyses and stepwise logistic regression.

Results

MAPT converters declined on language, attention, executive function, social cognition, and memory, and GRN converters declined on attention and executive function (p < 0.05). Cognitive decline in ScreeLing phonology (p = 0.046) and letter fluency (p = 0.046) were predictive for conversion to non-fluent variant PPA, and decline on categorical fluency (p = 0.025) for an underlying MAPT mutation.

Discussion

Using longitudinal neuropsychological assessment, we detected a mutation-specific pattern of cognitive decline, potentially suggesting prognostic value of neuropsychological trajectories in conversion to symptomatic FTD.

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Title: Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia
Authors: Lize C. Jiskoot
Jessica L. Panman
Lauren van Asseldonk
Sanne Franzen
Lieke H. H. Meeter
Laura Donker Kaat
Emma L. van der Ende
Elise G. P. Dopper
Reinier Timman
Rick van Minkelen
John C. van Swieten
Esther van den Berg
Janne M. Papma
Publication date: 01-06-2018
Publisher: Springer Berlin Heidelberg
Published in: Journal of Neurology / Issue 6/2018
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-018-8850-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia

Abstract

Introduction

Methods

Results

Discussion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Discussion

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