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01-01-2016 | Vascular-Interventional

Longitudinal assessment of carotid atherosclerosis after Radiation Therapy using Computed Tomography: A case control Study

Authors: Michele Anzidei, Jasjit S. Suri, Luca Saba, Roberto Sanfilippo, Giancarlo Laddeo, Roberto Montisci, Mario Piga, Giovanni Maria Argiolas, Eytan Raz

Published in: European Radiology | Issue 1/2016

Abstract

Objectives

To study the carotid artery plaque composition and its volume changes in a group of patients at baseline and 2 years after head and neck radiation therapy treatment (HNXRT).

Methods

In this retrospective study, 62 patients (41 males; mean age 63 years; range 52–81) who underwent HNXRT and 40 patients (24 males; mean age 65) who underwent surgical resection of neoplasm and did not undergo HNXRT were assessed, with 2-year follow-up. The carotid artery plaque volumes, as well as the volume of the sub-components (fatty-mixed-calcified), were semiautomatically quantified. Mann-Whitney and Wilcoxon tests were used to test the hypothesis.

Results

In the HNXRT group, there was a statistically significant increase in the total volume of the carotid artery plaques (from 533 to 746 mm³; p = 0.001), in the fatty plaques (103 vs. 202 mm³; p = 0.001) and mixed plaque component volume (328 vs. 419 mm³; p = 0.034). A statistically significant variation (from 21.8 % to 27.6 %) in the percentage of the fatty tissue was found.

Conclusions

Results

of this preliminary study suggest that HNXRT promotes increased carotid artery plaque volume, particularly the fatty plaque component.

Key Points

• HNXRT increases carotid plaque volume.

• Plaque volume increase is mainly due to increase.in fatty plaque component

• Patients who undergo HNXRT have a progression of carotid artery disease.

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Title: Longitudinal assessment of carotid atherosclerosis after Radiation Therapy using Computed Tomography: A case control Study
Authors: Michele Anzidei
Jasjit S. Suri
Luca Saba
Roberto Sanfilippo
Giancarlo Laddeo
Roberto Montisci
Mario Piga
Giovanni Maria Argiolas
Eytan Raz
Publication date: 01-01-2016
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 1/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3753-9

At a glance: The STEP trials

Springer Medicine

Longitudinal assessment of carotid atherosclerosis after Radiation Therapy using Computed Tomography: A case control Study

Abstract

Objectives

Methods

Results

Conclusions

Results

Key Points

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Results

Key Points

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