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BMC Pregnancy and Childbirth
Published in: BMC Pregnancy and Childbirth 1/2015

Open Access 01-12-2015 | Research article

Long-term trends and seasonality of omphalocele during 1996–2010 in China: a retrospective analysis based on the hospital-based birth defects surveillance system

Authors: Xiaohong Li, Li Dai, Yanping Wang, Lin Yi, Changfei Deng, Kui Deng, Guangxuan Zhou, Qi Li, Zheng Liu, Ying Deng, Jun Zhu, Xiaosong Li

Published in: BMC Pregnancy and Childbirth | Issue 1/2015

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Abstract

Background

Little is known about secular trends and seasonal variation in the birth prevalence of omphalocele in China. This study aimed to explore the long-term trends and seasonality of this birth defect, to provide insight into the etiology and prevention of omphalocele.

Methods

A retrospective analysis of all births with omphalocele (1322 cases in 8.8 million births) registered in the hospital-based Chinese Birth Defects Monitoring Network between January 1996 and September 2010. Negative binomial cyclical regression models were used to analyze the long-term trends and seasonal fluctuations of omphalocele occurrence in the southern and northern regions and urban and rural areas of China.

Results

The total prevalence of omphalocele was 1.50 cases (95% confidence interval (CI): 1.42–1.58) per 10,000 births. There was no significant secular trend of omphalocele occurrence in China between 1996 and 2010. The observed prevalence of omphalocele in rural areas was 2.03–2.54 cases per 10,000 births between May and August, which was higher than that observed in other months. The highest prevalence of births with omphalocele in rural areas occurred at the end of June; on average, the prevalence of omphalocele at that time point increased by 20% (95% CI: 6–35%) compared with other months.

Conclusions

There were no long-term trends found for occurrence of omphalocele in China between 1996 and 2010; however, seasonality was observed for omphalocele in women living in rural areas. These results may help generate hypotheses for further study of environmental factors that vary by season.
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Metadata
Title
Long-term trends and seasonality of omphalocele during 1996–2010 in China: a retrospective analysis based on the hospital-based birth defects surveillance system
Authors
Xiaohong Li
Li Dai
Yanping Wang
Lin Yi
Changfei Deng
Kui Deng
Guangxuan Zhou
Qi Li
Zheng Liu
Ying Deng
Jun Zhu
Xiaosong Li
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Pregnancy and Childbirth / Issue 1/2015
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-015-0530-3

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