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01-12-2012 | Original Article

Long-term results of primary and secondary resections in patients with retroperitoneal soft tissue sarcoma

Authors: Alexandra M. Koenig, Matthias Reeh, Christoph M. Burdelski, Claudia Wengert, Karim A. Gawad, Jakob R. Izbicki, Maximilian Bockhorn

Published in: Langenbeck's Archives of Surgery | Issue 8/2012

Abstract

Background and objectives

The aim of this study was to analyse treatment and long-term outcome for primary and recurrent disease in patients with retroperitoneal soft tissue sarcoma (RSTS).

Methods

Clinicopathological data including tumour stage, grade, and histological subtype, location of the principal tumour, completeness of resection and operative procedure were studied. Kaplan–Meier estimations and Cox regression analyses were performed.

Results

Patients comprised a primary resection group (PRG, n = 42), and a secondary resection group (SRG, n = 12) which included patients with recurrent RSTS and/or metastatic RSTS. Postoperative complications occurred in 15 patients (PRG: n = 13 (31%); SRG: n = 2, (16.7%)) and overall 30-day mortality was 5.6% (PRG: n = 2 (4.8%); SRG: n = 1 (8.3%)). Median overall survival was 58 months (PRG 60 months, SRG 50 months) with a 5-year survival rate of 39% (PRG 35.7%, SRG 50%) and a 1-year survival of 74.1% (PRG 71.4%, SRG 83.3%). Multivariate Cox regression analyses indicated that histopathological subtype (P = 0.006), completeness of resection (P < 0.001) and tumour grade (P = 0.018) were independent prognostic variables for overall survival.

Conclusion

In the absence of effective alternative treatment options, patients with RSTS should undergo extended resection, even in recurrent disease. Complete surgical resection is still the most effective modality for the treatment of retroperitoneal sarcoma.

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Title: Long-term results of primary and secondary resections in patients with retroperitoneal soft tissue sarcoma
Authors: Alexandra M. Koenig
Matthias Reeh
Christoph M. Burdelski
Claudia Wengert
Karim A. Gawad
Jakob R. Izbicki
Maximilian Bockhorn
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 8/2012
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-012-0941-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Long-term results of primary and secondary resections in patients with retroperitoneal soft tissue sarcoma

Abstract

Background and objectives

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background and objectives

Methods

Results

Conclusion

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