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International Archives of Occupational and Environmental Health

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Open Access 01-04-2012 | Original Article

Long-term lead elimination from plasma and whole blood after poisoning

Authors: Gerda Rentschler, K. Broberg, T. Lundh, S. Skerfving

Published in: International Archives of Occupational and Environmental Health | Issue 3/2012

Abstract

Objective

Blood lead (B–Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P–Pb) is more adequate.

Methods

A long-term follow-up study of five cases of lead poisoning. P–Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.

Results

P–Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P–Pb was about 1 month; B–Pb decay was much slower.

Conclusion

P–Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.

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Title: Long-term lead elimination from plasma and whole blood after poisoning
Authors: Gerda Rentschler
K. Broberg
T. Lundh
S. Skerfving
Publication date: 01-04-2012
Publisher: Springer-Verlag
Published in: International Archives of Occupational and Environmental Health / Issue 3/2012
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-011-0673-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Long-term lead elimination from plasma and whole blood after poisoning

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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