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Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 6/2012

01-06-2012 | Pediatrics

Long-term follow-up of changes in corneal endothelium after primary and secondary intraocular lens implantations in children

Authors: Mi Jeung Kim, Jeong Hun Kim, Seong-Joon Kim, Young Suk Yu

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 6/2012

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Abstract

Background

To evaluate long-term changes in corneal endothelial cell count and morphology after congenital cataract extraction and intraocular lens implantation.

Methods

Cataract extraction and posterior chamber intraocular lens (IOL) implantation was performed on 54 congenital cataract patients (83 eyes). The corneal endothelial cell density (ECD), coefficient of variation (CV), hexagonality, and central corneal thickness (CCT) were measured for a retrospective analysis of long-term changes in corneal endothelial characteristics.

Results

The mean age at the time of IOL implantation was 5.00 (3.62) years [mean (SD)], and the mean follow-up period was 8.83 (1.49) years. In a comparison of the treated and normal eyes of patients who underwent unilateral surgery, the treated eyes showed a significantly greater CCT (p < 0.05), and there was no significant difference in ECD, CV, and hexagonality (p > 0.05). In addition, there was no statistically significant difference in the ECD and CCT between the primary and secondary IOL implantation groups.

Conclusions

Our results did not show any significant corneal endothelial cell loss in congenital cataract patients; however, their CCTs were increased.
Literature
1.
go back to reference Foster A, Gilbert C, Rahi J (1997) Epidemiology of cataract in childhood: a global perspective. J Cataract Refract Surg 23(Suppl 1):601–604PubMed Foster A, Gilbert C, Rahi J (1997) Epidemiology of cataract in childhood: a global perspective. J Cataract Refract Surg 23(Suppl 1):601–604PubMed
2.
go back to reference Haddad MA, Sei M, Sampaio MW, Kara-Jose N (2007) Causes of visual impairment in children: a study of 3,210 cases. J Pediatr Ophthalmol Strabismus 44:232–240PubMed Haddad MA, Sei M, Sampaio MW, Kara-Jose N (2007) Causes of visual impairment in children: a study of 3,210 cases. J Pediatr Ophthalmol Strabismus 44:232–240PubMed
3.
go back to reference Cama AT, Sikivou BT, Keeffe JE (2010) Childhood visual impairment in Fiji. Arch Ophthalmol 128:608–612PubMedCrossRef Cama AT, Sikivou BT, Keeffe JE (2010) Childhood visual impairment in Fiji. Arch Ophthalmol 128:608–612PubMedCrossRef
4.
go back to reference Bhattacharjee H, Das K, Borah RR, Guha K, Gogate P, Purukayastha S, Gilbert C (2008) Causes of childhood blindness in the northeastern states of India. Indian J Ophthalmol 56:495–499PubMedCrossRef Bhattacharjee H, Das K, Borah RR, Guha K, Gogate P, Purukayastha S, Gilbert C (2008) Causes of childhood blindness in the northeastern states of India. Indian J Ophthalmol 56:495–499PubMedCrossRef
5.
go back to reference Steinkuller PG, Du L, Gilbert C, Foster A, Collins ML, Coats DK (1999) Childhood blindness. J AAPOS 3:26–32PubMedCrossRef Steinkuller PG, Du L, Gilbert C, Foster A, Collins ML, Coats DK (1999) Childhood blindness. J AAPOS 3:26–32PubMedCrossRef
6.
go back to reference Khan RI, O'Keefe M, Kenny D, Nolan L (2007) Changing pattern of childhood blindness. Ir Med J 100:458–461PubMed Khan RI, O'Keefe M, Kenny D, Nolan L (2007) Changing pattern of childhood blindness. Ir Med J 100:458–461PubMed
7.
go back to reference Maida JM, Mathers K, Alley CL (2008) Pediatric ophthalmology in the developing world. Curr Opin Ophthalmol 19:403–408PubMedCrossRef Maida JM, Mathers K, Alley CL (2008) Pediatric ophthalmology in the developing world. Curr Opin Ophthalmol 19:403–408PubMedCrossRef
8.
go back to reference Gogate P, Deshpande M, Sudrik S, Taras S, Kishore H, Gilbert C (2007) Changing pattern of childhood blindness in Maharashtra, India. Br J Ophthalmol 91:8–12PubMedCrossRef Gogate P, Deshpande M, Sudrik S, Taras S, Kishore H, Gilbert C (2007) Changing pattern of childhood blindness in Maharashtra, India. Br J Ophthalmol 91:8–12PubMedCrossRef
9.
go back to reference Vasavada AR, Nihalani BR (2006) Pediatric cataract surgery. Curr Opin Ophthalmol 17:54–615PubMed Vasavada AR, Nihalani BR (2006) Pediatric cataract surgery. Curr Opin Ophthalmol 17:54–615PubMed
10.
11.
go back to reference Lin AA, Buckley EG (2010) Update on pediatric cataract surgery and intraocular lens implantation. Curr Opin Ophthalmol 21:55–59PubMedCrossRef Lin AA, Buckley EG (2010) Update on pediatric cataract surgery and intraocular lens implantation. Curr Opin Ophthalmol 21:55–59PubMedCrossRef
12.
go back to reference Hutchinson AK, Wilson ME, Saunders RA (1998) Outcomes and ocular growth rates after intraocular lens implantation in the first 2 years of life. J Cataract Refract Surg 24:846–852PubMed Hutchinson AK, Wilson ME, Saunders RA (1998) Outcomes and ocular growth rates after intraocular lens implantation in the first 2 years of life. J Cataract Refract Surg 24:846–852PubMed
13.
go back to reference Thouvenin D (2011) Management of infantile cataracts: Surgical technics and choices in lens implantation. J Fr Ophtalmol 34:198–202PubMedCrossRef Thouvenin D (2011) Management of infantile cataracts: Surgical technics and choices in lens implantation. J Fr Ophtalmol 34:198–202PubMedCrossRef
14.
go back to reference Lloyd IC, Ashworth J, Biswas S, Abadi RV (2007) Advances in the management of congenital and infantile cataract. Eye (Lond) 21:1301–1309CrossRef Lloyd IC, Ashworth J, Biswas S, Abadi RV (2007) Advances in the management of congenital and infantile cataract. Eye (Lond) 21:1301–1309CrossRef
15.
go back to reference Binder PS, Sternberg H, Wickman MG, Worthen DM (1976) Corneal endothelial damage associated with phacoemulsification. Am J Ophthalmol 82:48–54PubMed Binder PS, Sternberg H, Wickman MG, Worthen DM (1976) Corneal endothelial damage associated with phacoemulsification. Am J Ophthalmol 82:48–54PubMed
16.
go back to reference Hayashi K, Hayashi H, Nakao F, Hayashi F (1996) Risk factors for corneal endothelial injury during phacoemulsification. J Cataract Refract Surg 22:1079–1084PubMed Hayashi K, Hayashi H, Nakao F, Hayashi F (1996) Risk factors for corneal endothelial injury during phacoemulsification. J Cataract Refract Surg 22:1079–1084PubMed
17.
go back to reference Joussen AM, Barth U, Cubuk H, Koch H (2000) Effect of irrigating solution and irrigation temperature on the cornea and pupil during phacoemulsification. J Cataract Refract Surg 26:392–397PubMedCrossRef Joussen AM, Barth U, Cubuk H, Koch H (2000) Effect of irrigating solution and irrigation temperature on the cornea and pupil during phacoemulsification. J Cataract Refract Surg 26:392–397PubMedCrossRef
18.
go back to reference Hyndiuk RA, Schultz RO (1992) Overview of the corneal toxicity of surgical solutions and drugs: and clinical concepts in corneal edema. Lens Eye Toxic Res 9:331–350PubMed Hyndiuk RA, Schultz RO (1992) Overview of the corneal toxicity of surgical solutions and drugs: and clinical concepts in corneal edema. Lens Eye Toxic Res 9:331–350PubMed
19.
go back to reference Cameron MD, Poyer JF, Aust SD (2001) Identification of free radicals produced during phacoemulsification. J Cataract Refract Surg 27:463–470PubMedCrossRef Cameron MD, Poyer JF, Aust SD (2001) Identification of free radicals produced during phacoemulsification. J Cataract Refract Surg 27:463–470PubMedCrossRef
20.
go back to reference Murano N, Ishizaki M, Sato S, Fukuda Y, Takahashi H (2008) Corneal endothelial cell damage by free radicals associated with ultrasound oscillation. Arch Ophthalmol 126:816PubMedCrossRef Murano N, Ishizaki M, Sato S, Fukuda Y, Takahashi H (2008) Corneal endothelial cell damage by free radicals associated with ultrasound oscillation. Arch Ophthalmol 126:816PubMedCrossRef
21.
go back to reference Liesegang TJ, Bourne WM, Ilstrup DM (1984) Short- and long-term endothelial cell loss associated with cataract extraction and intraocular lens implantation. Am J Ophthalmol 97:32–39PubMed Liesegang TJ, Bourne WM, Ilstrup DM (1984) Short- and long-term endothelial cell loss associated with cataract extraction and intraocular lens implantation. Am J Ophthalmol 97:32–39PubMed
22.
go back to reference Matsuda M, Miyake K, Inaba M (1988) Long-term corneal endothelial changes after intraocular lens implantation. Am J Ophthalmol 105:248–252PubMed Matsuda M, Miyake K, Inaba M (1988) Long-term corneal endothelial changes after intraocular lens implantation. Am J Ophthalmol 105:248–252PubMed
23.
go back to reference Bourne WM, Nelson LR, Hodge DO (1994) Continued endothelial cell loss ten years after lens implantation. Ophthalmology 101:1014–1022, discussion 1022–1013PubMed Bourne WM, Nelson LR, Hodge DO (1994) Continued endothelial cell loss ten years after lens implantation. Ophthalmology 101:1014–1022, discussion 1022–1013PubMed
24.
go back to reference Hayashi K, Hayashi H, Nakao F, Hayashi F (1996) Corneal endothelial cell loss in phacoemulsification surgery with silicone intraocular lens implantation. J Cataract Refract Surg 22:743–747PubMed Hayashi K, Hayashi H, Nakao F, Hayashi F (1996) Corneal endothelial cell loss in phacoemulsification surgery with silicone intraocular lens implantation. J Cataract Refract Surg 22:743–747PubMed
25.
go back to reference Stanley JA, Shearing SP, Anderson RR, Avallone AN (1980) Endothelial cell density after posterior chamber lens implantation. Ophthalmology 87:381–384PubMed Stanley JA, Shearing SP, Anderson RR, Avallone AN (1980) Endothelial cell density after posterior chamber lens implantation. Ophthalmology 87:381–384PubMed
26.
go back to reference Lesiewska-Junk H, Kaluzny J, Malukiewicz-Wisniewska G (2002) Long-term evaluation of endothelial cell loss after phacoemulsification. Eur J Ophthalmol 12:30–33PubMed Lesiewska-Junk H, Kaluzny J, Malukiewicz-Wisniewska G (2002) Long-term evaluation of endothelial cell loss after phacoemulsification. Eur J Ophthalmol 12:30–33PubMed
27.
go back to reference Kiss B, Findl O, Menapace R, Petternel V, Wirtitsch M, Lorang T, Gengler M, Drexler W (2003) Corneal endothelial cell protection with a dispersive viscoelastic material and an irrigating solution during phacoemulsification: low-cost versus expensive combination. J Cataract Refract Surg 29:733–740PubMedCrossRef Kiss B, Findl O, Menapace R, Petternel V, Wirtitsch M, Lorang T, Gengler M, Drexler W (2003) Corneal endothelial cell protection with a dispersive viscoelastic material and an irrigating solution during phacoemulsification: low-cost versus expensive combination. J Cataract Refract Surg 29:733–740PubMedCrossRef
28.
go back to reference Miyata K, Maruoka S, Nakahara M, Otani S, Nejima R, Samejima T, Amano S (2002) Corneal endothelial cell protection during phacoemulsification: low- versus high-molecular-weight sodium hyaluronate. J Cataract Refract Surg 28:1557–1560PubMedCrossRef Miyata K, Maruoka S, Nakahara M, Otani S, Nejima R, Samejima T, Amano S (2002) Corneal endothelial cell protection during phacoemulsification: low- versus high-molecular-weight sodium hyaluronate. J Cataract Refract Surg 28:1557–1560PubMedCrossRef
29.
go back to reference Oxford Cataract Treatment and Evaluation Team (OCTET)(1986) Long-term corneal endothelial cell loss after cataract surgery. Results of a randomized controlled trial. Arch Ophthalmol 104:1170–1175CrossRef Oxford Cataract Treatment and Evaluation Team (OCTET)(1986) Long-term corneal endothelial cell loss after cataract surgery. Results of a randomized controlled trial. Arch Ophthalmol 104:1170–1175CrossRef
30.
go back to reference Walkow T, Anders N, Klebe S (2000) Endothelial cell loss after phacoemulsification: relation to preoperative and intraoperative parameters. J Cataract Refract Surg 26:727–732PubMedCrossRef Walkow T, Anders N, Klebe S (2000) Endothelial cell loss after phacoemulsification: relation to preoperative and intraoperative parameters. J Cataract Refract Surg 26:727–732PubMedCrossRef
31.
go back to reference Zetterstrom C, Laurell CG (1995) Comparison of endothelial cell loss and phacoemulsification energy during endocapsular phacoemulsification surgery. J Cataract Refract Surg 21:55–58PubMed Zetterstrom C, Laurell CG (1995) Comparison of endothelial cell loss and phacoemulsification energy during endocapsular phacoemulsification surgery. J Cataract Refract Surg 21:55–58PubMed
32.
go back to reference Dick HB, Kohnen T, Jacobi FK, Jacobi KW (1996) Long-term endothelial cell loss following phacoemulsification through a temporal clear corneal incision. J Cataract Refract Surg 22:63–71PubMed Dick HB, Kohnen T, Jacobi FK, Jacobi KW (1996) Long-term endothelial cell loss following phacoemulsification through a temporal clear corneal incision. J Cataract Refract Surg 22:63–71PubMed
33.
go back to reference Diaz-Valle D, del Castillo B, Sanchez JM, Castillo A, Sayagues O, Moriche M (1998) Endothelial damage with cataract surgery techniques. J Cataract Refract Surg 24:951–955PubMed Diaz-Valle D, del Castillo B, Sanchez JM, Castillo A, Sayagues O, Moriche M (1998) Endothelial damage with cataract surgery techniques. J Cataract Refract Surg 24:951–955PubMed
34.
go back to reference Lucena DR, Ribeiro MS, Messias A, Bicas HE, Scott IU, Jorge R (2011) Comparison of corneal changes after phacoemulsification using BSS Plus versus Lactated Ringer's irrigating solution: a prospective randomised trial. Br J Ophthalmol 95:485–489PubMedCrossRef Lucena DR, Ribeiro MS, Messias A, Bicas HE, Scott IU, Jorge R (2011) Comparison of corneal changes after phacoemulsification using BSS Plus versus Lactated Ringer's irrigating solution: a prospective randomised trial. Br J Ophthalmol 95:485–489PubMedCrossRef
35.
go back to reference Kahraman G, Amon M, Franz C, Prinz A, Abela-Formanek C (2007) Intraindividual comparison of surgical trauma after bimanual microincision and conventional small-incision coaxial phacoemulsification. J Cataract Refract Surg 33:618–622PubMedCrossRef Kahraman G, Amon M, Franz C, Prinz A, Abela-Formanek C (2007) Intraindividual comparison of surgical trauma after bimanual microincision and conventional small-incision coaxial phacoemulsification. J Cataract Refract Surg 33:618–622PubMedCrossRef
36.
go back to reference Ventura AC, Walti R, Bohnke M (2001) Corneal thickness and endothelial density before and after cataract surgery. Br J Ophthalmol 85:18–20PubMedCrossRef Ventura AC, Walti R, Bohnke M (2001) Corneal thickness and endothelial density before and after cataract surgery. Br J Ophthalmol 85:18–20PubMedCrossRef
37.
go back to reference Basti S, Aasuri MK, Reddy S, Rao GN (1998) Prospective evaluation of corneal endothelial cell loss after pediatric cataract surgery. J Cataract Refract Surg 24:1469–1473PubMed Basti S, Aasuri MK, Reddy S, Rao GN (1998) Prospective evaluation of corneal endothelial cell loss after pediatric cataract surgery. J Cataract Refract Surg 24:1469–1473PubMed
38.
go back to reference Urban B, Bakunowicz-lazarczyk A, Kretowska M (2005) Evaluation of corneal endothelium after pediatric cataract surgery in children and adolescents. Klin Oczna 107:43–45PubMed Urban B, Bakunowicz-lazarczyk A, Kretowska M (2005) Evaluation of corneal endothelium after pediatric cataract surgery in children and adolescents. Klin Oczna 107:43–45PubMed
39.
go back to reference Nilforushan N, Falavarjani KG, Razeghinejad MR, Bakhtiari P (2007) Cataract surgery for congenital cataract: endothelial cell characteristics, corneal thickness, and impact on intraocular pressure. J AAPOS 11:159–161PubMedCrossRef Nilforushan N, Falavarjani KG, Razeghinejad MR, Bakhtiari P (2007) Cataract surgery for congenital cataract: endothelial cell characteristics, corneal thickness, and impact on intraocular pressure. J AAPOS 11:159–161PubMedCrossRef
40.
go back to reference Kora Y, Inatomi M, Fukado Y, Marumori M, Yaguchi S (1992) Long-term study of children with implanted intraocular lenses. J Cataract Refract Surg 18:485–488PubMed Kora Y, Inatomi M, Fukado Y, Marumori M, Yaguchi S (1992) Long-term study of children with implanted intraocular lenses. J Cataract Refract Surg 18:485–488PubMed
41.
go back to reference Hardten DR (1996) The cornea in cataract and intraocular lens surgery. Curr Opin Ophthalmol 7:43–48PubMedCrossRef Hardten DR (1996) The cornea in cataract and intraocular lens surgery. Curr Opin Ophthalmol 7:43–48PubMedCrossRef
42.
go back to reference Hardten DR (1997) The cornea in cataract and intraocular lens surgery. Curr Opin Ophthalmol 8:33–38PubMed Hardten DR (1997) The cornea in cataract and intraocular lens surgery. Curr Opin Ophthalmol 8:33–38PubMed
43.
go back to reference Baum JL, Niedra R, Davis C, Yue BY (1979) Mass culture of human corneal endothelial cells. Arch Ophthalmol 97:1136–1140PubMedCrossRef Baum JL, Niedra R, Davis C, Yue BY (1979) Mass culture of human corneal endothelial cells. Arch Ophthalmol 97:1136–1140PubMedCrossRef
44.
go back to reference Amino K, Miyahara S, Tanihara H (2004) Corneal thickness in eyes following pars plana lensectomy for congenital cataracts. Jpn J Ophthalmol 48:169–171PubMedCrossRef Amino K, Miyahara S, Tanihara H (2004) Corneal thickness in eyes following pars plana lensectomy for congenital cataracts. Jpn J Ophthalmol 48:169–171PubMedCrossRef
45.
go back to reference Simon JW, O'Malley MR, Gandham SB, Ghaiy R, Zobal-Ratner J, Simmons ST (2005) Central corneal thickness and glaucoma in aphakic and pseudophakic children. J AAPOS 9:326–329PubMedCrossRef Simon JW, O'Malley MR, Gandham SB, Ghaiy R, Zobal-Ratner J, Simmons ST (2005) Central corneal thickness and glaucoma in aphakic and pseudophakic children. J AAPOS 9:326–329PubMedCrossRef
46.
go back to reference Simon JW, Miter D, Zobal-Ratner J, Hodgetts D, Belin MW (1997) Corneal edema after pediatric cataract surgery. J AAPOS 1:102–104PubMedCrossRef Simon JW, Miter D, Zobal-Ratner J, Hodgetts D, Belin MW (1997) Corneal edema after pediatric cataract surgery. J AAPOS 1:102–104PubMedCrossRef
47.
go back to reference Lupinacci AP, da Silva Jordao ML, Massa G, Arieta CE, Costa VP (2009) Central corneal thickness in children with congenital cataract and children with surgical aphakia: a case–control study. Br J Ophthalmol 93:337–341PubMedCrossRef Lupinacci AP, da Silva Jordao ML, Massa G, Arieta CE, Costa VP (2009) Central corneal thickness in children with congenital cataract and children with surgical aphakia: a case–control study. Br J Ophthalmol 93:337–341PubMedCrossRef
48.
go back to reference Krachmer JH, Mannis MJ, Holland EJ (2011) Cornea, Third Edition. Mosby Elsevier, Maryland Heights Krachmer JH, Mannis MJ, Holland EJ (2011) Cornea, Third Edition. Mosby Elsevier, Maryland Heights
Metadata
Title
Long-term follow-up of changes in corneal endothelium after primary and secondary intraocular lens implantations in children
Authors
Mi Jeung Kim
Jeong Hun Kim
Seong-Joon Kim
Young Suk Yu
Publication date
01-06-2012
Publisher
Springer-Verlag
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 6/2012
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-011-1872-9

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