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BMC Immunology
Published in: BMC Immunology 1/2006

Open Access 01-12-2006 | Research article

Long-term changes of serum chemokine levels in vaccinated military personnel

Authors: Beda Brichacek, Christophe Vanpouille, Alexander J Trachtenberg, Tatiana Pushkarsky, Larisa Dubrovsky, Gregory Martin, Gary Simon, Michael Bukrinsky

Published in: BMC Immunology | Issue 1/2006

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Abstract

Background

Members of the United States Armed Forces receive a series of vaccinations during their course of service. To investigate the influence of multiple vaccinations on innate immunity, we measured concentrations of a panel of immunomodulatory and pro-inflammatory cytokines in serum samples from a group of such individuals.

Results

Significantly increased levels of macrophage inflammatory protein 1α (MIP-1α), MIP-1β and interleukin 8 (IL-8) were detected. Since these cytokines are known to have anti-human immunodeficiency virus (HIV) activity, we tested the effect of serum from these individuals on HIV-1 infectivity and susceptibility of their peripheral blood mononuclear cells (PBMCs) to HIV-1 infection in vitro. Sera from vaccinated military personnel inhibited, and their PBMCs were partially resistant to, infection by HIV-1 strains tropic to CCR5 (R5), but not to CXCR4 (X4), chemokine receptor.

Conclusion

These findings demonstrate that increased anti-HIV chemokines can be detected in vaccine recipients up to 68 weeks following immunization.
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Metadata
Title
Long-term changes of serum chemokine levels in vaccinated military personnel
Authors
Beda Brichacek
Christophe Vanpouille
Alexander J Trachtenberg
Tatiana Pushkarsky
Larisa Dubrovsky
Gregory Martin
Gary Simon
Michael Bukrinsky
Publication date
01-12-2006
Publisher
BioMed Central
Published in
BMC Immunology / Issue 1/2006
Electronic ISSN: 1471-2172
DOI
https://doi.org/10.1186/1471-2172-7-21

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