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Published in: Investigational New Drugs 2/2019

01-04-2019 | SHORT REPORT

Long-term adverse event: inflammatory orbitopathy induced by pembrolizumab in a patient with metastatic melanoma

Authors: Charlée Nardin, Sophie Borot, Marie-Astride Beaudoin, Françoise Cattin, Eve Puzenat, Anne-Sophie Gauthier, Franck Schillo, Christophe Borg, François Aubin

Published in: Investigational New Drugs | Issue 2/2019

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Summary

The recent advent of immune checkpoint inhibitors (ICI), including anti-programmed cell death 1 protein (anti-PD-1) agents has revolutionized the therapeutic approach of metastatic malignancies. Yet, ICI can disrupt immune tolerance resulting in enhanced immune activation in normal tissues with significant toxicity. A dysregulated activation of T-cells directed to normal tissues stands as the main mechanism of immune-related adverse events (irAE). To date, only two cases of immune-related inflammatory orbitopathy related to anti-PD-1 agents have been reported. This rare immune adverse event usually occurred early after ICI initiation. Here, we report the first case of late inflammatory orbitopathy occurring in a melanoma patient treated with pembrolizumab. Consequently, the occurrence of irAE under ICI should be monitored, even late after treatment instauration.
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Metadata
Title
Long-term adverse event: inflammatory orbitopathy induced by pembrolizumab in a patient with metastatic melanoma
Authors
Charlée Nardin
Sophie Borot
Marie-Astride Beaudoin
Françoise Cattin
Eve Puzenat
Anne-Sophie Gauthier
Franck Schillo
Christophe Borg
François Aubin
Publication date
01-04-2019
Publisher
Springer US
Published in
Investigational New Drugs / Issue 2/2019
Print ISSN: 0167-6997
Electronic ISSN: 1573-0646
DOI
https://doi.org/10.1007/s10637-018-0659-9

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