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General Thoracic and Cardiovascular Surgery

Published in:

01-05-2019 | Original Article

Long agonal period deteriorates cardiac death donor lung function in a rat EVLP model

Authors: Kyoko Hijiya, Toyofumi Fengshi Chen-Yoshikawa, Hideki Motoyama, Akihiro Ohsumi, Daisuke Nakajima, Jin Sakamoto, Akihiro Aoyama, Hiroshi Date

Published in: General Thoracic and Cardiovascular Surgery | Issue 5/2019

Abstract

Purpose

We investigated the impact of the duration of agonal period on donor lung function after reperfusion in an ex vivo rat lung perfusion model.

Methods

Three mechanical hypoventilation conditions were used for three agonal periods, which were defined as the interval between the start of hypoventilation and the time when systolic arterial blood pressure reached < 50 mmHg, i.e., < 10, 30–60, and 150–200 min for very short (VS), short (S), and long (L) groups (n = 5 rats/group). After flushing the lung, heart–lung blocks were reperfused ex vivo for 120 min; physiological data were obtained throughout the reperfusion process.

Results

Pulmonary vascular resistance was significantly higher throughout reperfusion in group L than in the other two groups (p < 0.05). After reperfusion, oxygenation was worse and pulmonary edema was more severe in group L than in group S (p < 0.05). Potassium concentrations in the perfusates were significantly higher in group L than in group VS. Histological analysis revealed more severe injury in group L than in the other two groups.

Conclusions

Long agonal periods may lead to deterioration of donor lung function; short intervals may not significantly affect donor lung function.

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Title: Long agonal period deteriorates cardiac death donor lung function in a rat EVLP model
Authors: Kyoko Hijiya
Toyofumi Fengshi Chen-Yoshikawa
Hideki Motoyama
Akihiro Ohsumi
Daisuke Nakajima
Jin Sakamoto
Akihiro Aoyama
Hiroshi Date
Publication date: 01-05-2019
Publisher: Springer Singapore
Published in: General Thoracic and Cardiovascular Surgery / Issue 5/2019
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI: https://doi.org/10.1007/s11748-018-1038-3

At a glance: The STEP trials

Springer Medicine

Long agonal period deteriorates cardiac death donor lung function in a rat EVLP model

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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