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01-12-2013 | Editorial

Long-Acting Growth Hormone

Authors: Charlotte Höybye, Jens Sandahl Christiansen

Published in: Pediatric Drugs | Issue 6/2013

Excerpt

Human growth hormone (GH) is a 22 kDa protein synthesized and secreted in the anterior pituitary gland. GH synthesis and release is induced by hypothalamic GH-releasing hormone (GHRH) and ghrelin and attenuated by somatostatin and negative feedback by insulin-like growth factor (IGF)-I [1]. The secretion of GH is episodic with several secretory peaks. The majority of spontaneous peaks occur during sleep, but it is also influenced by age, gender, intercurrent and chronic illnesses, and by nutritional status [1, 2]. …

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Hoffman AR, Biller BM, Cook D, Baptista J, Silverman BL, Dao L, Attie KM, Fielder P, Maneatis T, Lippe B. Genentech Adult Growth Hormone Deficiency Study, G. Efficacy of a long-acting growth hormone (GH) preparation in patients with adult GH deficiency. J Clin Endocrinol Metab. 2005;90(12):6431–40.PubMedCrossRef

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Biller BM, Ji HJ, Ahn H, Savoy C, Siepl EC, Popovic V, Coculescu M, Roemmler J, Gavrila C, Cook DM, Strasburger CJ. Effect of once-weekly sustained-release growth hormone: a double-blind, placebo-controlled study in adult growth hormone deficiency. J Clin Endocrinol Metab. 2011;96(6):1718–26.PubMedCrossRef

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Sondergaard E, Klose M, Hansen M, Hansen BS, Andersen M, Feldt-Rasmussen U, Laursen T, Rasmussen MH, Christiansen JS. Pegylated long-acting human growth hormone possesses a promising once-weekly treatment profile, and multiple dosing is well tolerated in adult patients with growth hormone deficiency. J Clin Endocrinol Metab. 2011;96(3):681–8.PubMedCrossRef

Title: Long-Acting Growth Hormone
Authors: Charlotte Höybye
Jens Sandahl Christiansen
Publication date: 01-12-2013
Publisher: Springer International Publishing
Published in: Pediatric Drugs / Issue 6/2013
Print ISSN: 1174-5878
Electronic ISSN: 1179-2019
DOI: https://doi.org/10.1007/s40272-013-0059-8

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